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Increased fat in pancreas not associated with risk of pancreatitis post-endoscopic retrograde cholangiopancreatography.

Pokhrel B, Choi EK, Khalid O, Sandrasegaran K, Fogel EL, McHenry L, Sherman S, Watkins J, Cote GA, Pitt HA, Zyromski NJ, Juliar B, Lehman GA - Clin Exp Gastroenterol (2014)

Bottom Line: A preliminary study has shown increased pancreatic fat in patients with idiopathic pancreatitis and sphincter of Oddi dysfunction.Percentage of fat was determined by recording signal intensity in the in-phase (Sin) and out-of-phase (Sout) T1-weighted gradient sequences, and calculation of the fat fraction as (Sin - Sout)/(Sin) × 2 by an abdominal radiologist blinded to clinical history.Measurements of pancreatic head, body, and tail fat and body mass index were similar in patients and controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.

ABSTRACT

Background: A preliminary study has shown increased pancreatic fat in patients with idiopathic pancreatitis and sphincter of Oddi dysfunction. In this study, we aimed to determine if an increased quantity of pancreatic fat is an independent risk factor for pancreatitis post-endoscopic retrograde cholangiopancreatography (ERCP).

Methods: In this case control study, we retrospectively reviewed a local radiological and ERCP database to identify patients who had had abdominal magnetic resonance imaging (MRI) followed by ERCP no more than 60 days later between September 2003 and January 2011. Percentage of fat was determined by recording signal intensity in the in-phase (Sin) and out-of-phase (Sout) T1-weighted gradient sequences, and calculation of the fat fraction as (Sin - Sout)/(Sin) × 2 by an abdominal radiologist blinded to clinical history. Controls matched for age, gender, and other pancreatobiliary disease were selected from a group with no post-ERCP pancreatitis (before fat content of the pancreas was analyzed).

Results: Forty-seven patients were enrolled. Compared with controls, subjects with post-ERCP pancreatitis were similar in terms of age (41.4 years versus 41.1 years), gender (21.2% versus 20.2% males), pancreatobiliary disease characteristics, and most ERCP techniques. Measurements of pancreatic head, body, and tail fat and body mass index were similar in patients and controls.

Conclusion: Increased pancreatic fat on MRI criteria is not an independent predictor of post-ERCP pancreatitis.

No MeSH data available.


Related in: MedlinePlus

Fat content of head, body, and tail of pancreas in patients with PEP.Abbreviation: PEP, post-endoscopic retrograde cholangiopan-creatography pancreatisis.
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f3-ceg-7-199: Fat content of head, body, and tail of pancreas in patients with PEP.Abbreviation: PEP, post-endoscopic retrograde cholangiopan-creatography pancreatisis.

Mentions: Table 3 summarizes the fat content between the two groups. Figures 3 and 4 show the distribution of fat content in cases of post-ERCP pancreatitis and controls. The mean fat content in the head of the pancreas (4.9% versus 5.5%) was numerically lower in patients with post-ERCP pancreatitis in comparison with the control population. The mean fat content in the body (6.2% versus 5.4%) and tail (5.3% versus 4.9%) of the pancreas was numerically higher in patients with post-ERCP pancreatitis. None of the differences were statistically significant.


Increased fat in pancreas not associated with risk of pancreatitis post-endoscopic retrograde cholangiopancreatography.

Pokhrel B, Choi EK, Khalid O, Sandrasegaran K, Fogel EL, McHenry L, Sherman S, Watkins J, Cote GA, Pitt HA, Zyromski NJ, Juliar B, Lehman GA - Clin Exp Gastroenterol (2014)

Fat content of head, body, and tail of pancreas in patients with PEP.Abbreviation: PEP, post-endoscopic retrograde cholangiopan-creatography pancreatisis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061141&req=5

f3-ceg-7-199: Fat content of head, body, and tail of pancreas in patients with PEP.Abbreviation: PEP, post-endoscopic retrograde cholangiopan-creatography pancreatisis.
Mentions: Table 3 summarizes the fat content between the two groups. Figures 3 and 4 show the distribution of fat content in cases of post-ERCP pancreatitis and controls. The mean fat content in the head of the pancreas (4.9% versus 5.5%) was numerically lower in patients with post-ERCP pancreatitis in comparison with the control population. The mean fat content in the body (6.2% versus 5.4%) and tail (5.3% versus 4.9%) of the pancreas was numerically higher in patients with post-ERCP pancreatitis. None of the differences were statistically significant.

Bottom Line: A preliminary study has shown increased pancreatic fat in patients with idiopathic pancreatitis and sphincter of Oddi dysfunction.Percentage of fat was determined by recording signal intensity in the in-phase (Sin) and out-of-phase (Sout) T1-weighted gradient sequences, and calculation of the fat fraction as (Sin - Sout)/(Sin) × 2 by an abdominal radiologist blinded to clinical history.Measurements of pancreatic head, body, and tail fat and body mass index were similar in patients and controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.

ABSTRACT

Background: A preliminary study has shown increased pancreatic fat in patients with idiopathic pancreatitis and sphincter of Oddi dysfunction. In this study, we aimed to determine if an increased quantity of pancreatic fat is an independent risk factor for pancreatitis post-endoscopic retrograde cholangiopancreatography (ERCP).

Methods: In this case control study, we retrospectively reviewed a local radiological and ERCP database to identify patients who had had abdominal magnetic resonance imaging (MRI) followed by ERCP no more than 60 days later between September 2003 and January 2011. Percentage of fat was determined by recording signal intensity in the in-phase (Sin) and out-of-phase (Sout) T1-weighted gradient sequences, and calculation of the fat fraction as (Sin - Sout)/(Sin) × 2 by an abdominal radiologist blinded to clinical history. Controls matched for age, gender, and other pancreatobiliary disease were selected from a group with no post-ERCP pancreatitis (before fat content of the pancreas was analyzed).

Results: Forty-seven patients were enrolled. Compared with controls, subjects with post-ERCP pancreatitis were similar in terms of age (41.4 years versus 41.1 years), gender (21.2% versus 20.2% males), pancreatobiliary disease characteristics, and most ERCP techniques. Measurements of pancreatic head, body, and tail fat and body mass index were similar in patients and controls.

Conclusion: Increased pancreatic fat on MRI criteria is not an independent predictor of post-ERCP pancreatitis.

No MeSH data available.


Related in: MedlinePlus