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Influence of aging on medial olivocochlear system function.

Lisowska G, Namyslowski G, Orecka B, Misiolek M - Clin Interv Aging (2014)

Bottom Line: Comparative analysis of the MOC effect for CEOAE and DPOAE showed the weakest effect in the oldest age group (41-60 years) at almost all tested frequencies.Moreover, a weak, albeit significant, positive correlation between the level of OAE and the size of the MOC effect was documented.On the basis of our study, we have found a decrease in the strength of the MOC system with increasing age in normally hearing subjects, as reflected by a decrease of the OAE suppression effects in older individuals and an increase of the number of CEOAE and DPOAE enhancements during contralateral acoustic stimulation in the elderly, especially in the high-frequency range.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Medical University of Silesia, Zabrze, Poland.

ABSTRACT

Background: There is still controversy regarding the influence of aging on medial olivocochlear (MOC) system function. The main objective of this study is to measure age-related changes of MOC system function in people with normal hearing thresholds.

Method: Bilateral assessment of the MOC effect for click-evoked otoacoustic emissions (CEOAEs; at 70±3 dB peak sound pressure level [pSPL], click at 50/second, 260 repeats, 2.5-20 millisecond window) and for distortion product otoacoustic emissions (DPOAEs; with [frequencies] f2/f1=1.22, [levels of primary tones] L1=65 dB SPL and L2=55 dB SPL; DP-grams for 2f1-f2 were collected for the f1 frequencies varying from 977 Hz to 5,164 kHz, with the resolution of four points per octave) was performed in a group of 146 (n=292 ears) healthy, right-handed subjects aged from 10-60 years with a bilateral hearing threshold from 0.25-4.0 kHz, not exceeding 20 dB hearing level; normal tympanograms; and a threshold of the contralateral stapedial reflex for broadband noise (BBN) of 75 dB SPL or higher. The MOC inhibition was assessed on the basis of changes in OAE level during BBN contralateral stimulation at 50 dB sensation level (mean, 65±3 dB SPL).

Results: Comparative analysis of the MOC effect for CEOAE and DPOAE showed the weakest effect in the oldest age group (41-60 years) at almost all tested frequencies. Moreover, a weak, albeit significant, positive correlation between the level of OAE and the size of the MOC effect was documented.

Conclusion: On the basis of our study, we have found a decrease in the strength of the MOC system with increasing age in normally hearing subjects, as reflected by a decrease of the OAE suppression effects in older individuals and an increase of the number of CEOAE and DPOAE enhancements during contralateral acoustic stimulation in the elderly, especially in the high-frequency range.

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Comparison of distortion product otoacoustic emissions (DPOAE) levels for particular distortion product otoacoustic emissions f1 frequencies (mean ± 95% confidence interval) in three age groups.
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f4-cia-9-901: Comparison of distortion product otoacoustic emissions (DPOAE) levels for particular distortion product otoacoustic emissions f1 frequencies (mean ± 95% confidence interval) in three age groups.

Mentions: The DPOAE level without CAS was compared among the tested age groups (ANOVA with appropriate post hoc Tukey test), and it was concluded that DPOAE level in the tested frequency range was highest in the 10–25 year age group, lower in the 26–40 year subgroup, and lowest in the 41–60 year subgroup. The detailed results and the comparisons between all subgroups are presented in Table 7 and Figure 4.


Influence of aging on medial olivocochlear system function.

Lisowska G, Namyslowski G, Orecka B, Misiolek M - Clin Interv Aging (2014)

Comparison of distortion product otoacoustic emissions (DPOAE) levels for particular distortion product otoacoustic emissions f1 frequencies (mean ± 95% confidence interval) in three age groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061140&req=5

f4-cia-9-901: Comparison of distortion product otoacoustic emissions (DPOAE) levels for particular distortion product otoacoustic emissions f1 frequencies (mean ± 95% confidence interval) in three age groups.
Mentions: The DPOAE level without CAS was compared among the tested age groups (ANOVA with appropriate post hoc Tukey test), and it was concluded that DPOAE level in the tested frequency range was highest in the 10–25 year age group, lower in the 26–40 year subgroup, and lowest in the 41–60 year subgroup. The detailed results and the comparisons between all subgroups are presented in Table 7 and Figure 4.

Bottom Line: Comparative analysis of the MOC effect for CEOAE and DPOAE showed the weakest effect in the oldest age group (41-60 years) at almost all tested frequencies.Moreover, a weak, albeit significant, positive correlation between the level of OAE and the size of the MOC effect was documented.On the basis of our study, we have found a decrease in the strength of the MOC system with increasing age in normally hearing subjects, as reflected by a decrease of the OAE suppression effects in older individuals and an increase of the number of CEOAE and DPOAE enhancements during contralateral acoustic stimulation in the elderly, especially in the high-frequency range.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Medical University of Silesia, Zabrze, Poland.

ABSTRACT

Background: There is still controversy regarding the influence of aging on medial olivocochlear (MOC) system function. The main objective of this study is to measure age-related changes of MOC system function in people with normal hearing thresholds.

Method: Bilateral assessment of the MOC effect for click-evoked otoacoustic emissions (CEOAEs; at 70±3 dB peak sound pressure level [pSPL], click at 50/second, 260 repeats, 2.5-20 millisecond window) and for distortion product otoacoustic emissions (DPOAEs; with [frequencies] f2/f1=1.22, [levels of primary tones] L1=65 dB SPL and L2=55 dB SPL; DP-grams for 2f1-f2 were collected for the f1 frequencies varying from 977 Hz to 5,164 kHz, with the resolution of four points per octave) was performed in a group of 146 (n=292 ears) healthy, right-handed subjects aged from 10-60 years with a bilateral hearing threshold from 0.25-4.0 kHz, not exceeding 20 dB hearing level; normal tympanograms; and a threshold of the contralateral stapedial reflex for broadband noise (BBN) of 75 dB SPL or higher. The MOC inhibition was assessed on the basis of changes in OAE level during BBN contralateral stimulation at 50 dB sensation level (mean, 65±3 dB SPL).

Results: Comparative analysis of the MOC effect for CEOAE and DPOAE showed the weakest effect in the oldest age group (41-60 years) at almost all tested frequencies. Moreover, a weak, albeit significant, positive correlation between the level of OAE and the size of the MOC effect was documented.

Conclusion: On the basis of our study, we have found a decrease in the strength of the MOC system with increasing age in normally hearing subjects, as reflected by a decrease of the OAE suppression effects in older individuals and an increase of the number of CEOAE and DPOAE enhancements during contralateral acoustic stimulation in the elderly, especially in the high-frequency range.

Show MeSH
Related in: MedlinePlus