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Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.

Yang G, Chen J, Xu F, Bao Z, Yao Y, Zhou J - PLoS ONE (2014)

Bottom Line: The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001).Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians.Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI%  = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

ABSTRACT

Objective: The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.

Methods: We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.

Results: A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI%  = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

Conclusions: This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.

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Related in: MedlinePlus

Begg’s funnel plot for publication bias on asthma risk and the TNF-α rs1800629 polymorphism.
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pone-0099962-g004: Begg’s funnel plot for publication bias on asthma risk and the TNF-α rs1800629 polymorphism.

Mentions: To assess the stability of the results of this meta-analysis, sensitivity analysis was performed by sequentially excluding each study. As shown in Figure 3, sensitivity analyses indicated that the three independent studies by Shin et al. [18], Shaker et al. [39] and Trajkov et al. [29] were the main origin of the heterogeneity in the overall comparisons. The heterogeneity was obviously decreased after exclusion of these three studies (G vs. A: OR = 0.69, 95%CI = 0.61–0.78, P<0.00001, I2 = 35%; GA+AA vs. GG: OR = 1.51, 95%CI = 1.31–1.73, P<0.00001, I2 = 37%). Meanwhile, similar result was obtained when any single study was omitted (Figure 3). Furthermore, the pooled ORs were not significantly altered after omitting the studies which the sample size was less than 50 cases in each group (OR = 1.38, 95%CI = 1.13–1.67, P<0.001), indicating that the results of this meta-analysis were relatively stable. The shape of the funnel plot seemed symmetrical (Figure 4), and neither Egger’s test nor Begg’s test indicated any significant publication bias (P = 0.191 and 0.286, respectively).


Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.

Yang G, Chen J, Xu F, Bao Z, Yao Y, Zhou J - PLoS ONE (2014)

Begg’s funnel plot for publication bias on asthma risk and the TNF-α rs1800629 polymorphism.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061054&req=5

pone-0099962-g004: Begg’s funnel plot for publication bias on asthma risk and the TNF-α rs1800629 polymorphism.
Mentions: To assess the stability of the results of this meta-analysis, sensitivity analysis was performed by sequentially excluding each study. As shown in Figure 3, sensitivity analyses indicated that the three independent studies by Shin et al. [18], Shaker et al. [39] and Trajkov et al. [29] were the main origin of the heterogeneity in the overall comparisons. The heterogeneity was obviously decreased after exclusion of these three studies (G vs. A: OR = 0.69, 95%CI = 0.61–0.78, P<0.00001, I2 = 35%; GA+AA vs. GG: OR = 1.51, 95%CI = 1.31–1.73, P<0.00001, I2 = 37%). Meanwhile, similar result was obtained when any single study was omitted (Figure 3). Furthermore, the pooled ORs were not significantly altered after omitting the studies which the sample size was less than 50 cases in each group (OR = 1.38, 95%CI = 1.13–1.67, P<0.001), indicating that the results of this meta-analysis were relatively stable. The shape of the funnel plot seemed symmetrical (Figure 4), and neither Egger’s test nor Begg’s test indicated any significant publication bias (P = 0.191 and 0.286, respectively).

Bottom Line: The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001).Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians.Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI%  = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

ABSTRACT

Objective: The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.

Methods: We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.

Results: A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI%  = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

Conclusions: This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.

Show MeSH
Related in: MedlinePlus