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Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.

Yang G, Chen J, Xu F, Bao Z, Yao Y, Zhou J - PLoS ONE (2014)

Bottom Line: The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001).Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians.Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI%  = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

ABSTRACT

Objective: The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.

Methods: We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.

Results: A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI%  = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

Conclusions: This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.

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Related in: MedlinePlus

Study flow chart of identification, inclusion, and exclusion.
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pone-0099962-g001: Study flow chart of identification, inclusion, and exclusion.

Mentions: The flow diagram in Figure 1 summarizes selection process of this literature review. Eventually, a total of 32 eligible articles completely met the inclusion criteria were incorporated into this meta-analysis [5], [10]–[29], [31]–[33], [35]–[40]. Two articles reported two cohorts, and each cohort was considered as a case-control study [5], [11]. At last, there were 34 case-control studies in 32 articles concerning association between the TNF-α rs1800629 polymorphism and asthma risk. There were seven studies performed in Caucasians, 24 studies in Asians. 14 studies involved children alone, 11 recruited adults and six included both children and adults. Four studies included only atopic asthma patients, 12 studies included both of atopic and non-atopic asthma patients, but only three studies of these can be extracted separately. The characteristics of these studies are shown in Table 1. The detailed genotype and frequencies and HWE examination results are listed in Table 2.


Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.

Yang G, Chen J, Xu F, Bao Z, Yao Y, Zhou J - PLoS ONE (2014)

Study flow chart of identification, inclusion, and exclusion.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061054&req=5

pone-0099962-g001: Study flow chart of identification, inclusion, and exclusion.
Mentions: The flow diagram in Figure 1 summarizes selection process of this literature review. Eventually, a total of 32 eligible articles completely met the inclusion criteria were incorporated into this meta-analysis [5], [10]–[29], [31]–[33], [35]–[40]. Two articles reported two cohorts, and each cohort was considered as a case-control study [5], [11]. At last, there were 34 case-control studies in 32 articles concerning association between the TNF-α rs1800629 polymorphism and asthma risk. There were seven studies performed in Caucasians, 24 studies in Asians. 14 studies involved children alone, 11 recruited adults and six included both children and adults. Four studies included only atopic asthma patients, 12 studies included both of atopic and non-atopic asthma patients, but only three studies of these can be extracted separately. The characteristics of these studies are shown in Table 1. The detailed genotype and frequencies and HWE examination results are listed in Table 2.

Bottom Line: The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001).Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians.Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI%  = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

ABSTRACT

Objective: The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.

Methods: We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.

Results: A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI%  = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

Conclusions: This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.

Show MeSH
Related in: MedlinePlus