Limits...
Decreased expression of C10orf10 and its prognostic significance in human breast cancer.

Deng J, Dong Y, Li C, Zuo W, Meng G, Xu C, Li J - PLoS ONE (2014)

Bottom Line: Here, we identified C10orf10 as a novel differentially expression gene using expression microarray screening.Kaplan-Meier analysis indicated that patients with low C10orf10 expression showed a poorer prognosis both in mRNA (n = 1115, P = 0.0013) and protein (n = 100, P = 0.003) levels.Further analysis revealed that low expression of C10orf10 was an unfavorable factor for the prognosis of the patients who were luminal A, luminal B, Her2+ subtypes, at histological grade 2, lymph node negative and ER positive.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing, China; Cadre's Sanatorium, Third Military Medical University, Chongqing, China.

ABSTRACT
Breast cancer is a common malignant tumor, which severely threatens the health of women with an increasing incidence in many countries. Here, we identified C10orf10 as a novel differentially expression gene using expression microarray screening. The expression analysis indicated that C10orf10 was frequently decreased in human breast cancers compared to noncancerous breast tissues (81/95, P = 0.0063). Kaplan-Meier analysis indicated that patients with low C10orf10 expression showed a poorer prognosis both in mRNA (n = 1115, P = 0.0013) and protein (n = 100, P = 0.003) levels. Univariate and multivariate analysis showed that the C10orf10 expression was an independent prognostic factor for overall survival of breast cancer patients. Further analysis revealed that low expression of C10orf10 was an unfavorable factor for the prognosis of the patients who were luminal A, luminal B, Her2+ subtypes, at histological grade 2, lymph node negative and ER positive. Our data provided the first evidence that C10orf10 expression was frequently decreased in breast cancer tissues, and low expression of C10orf10 may be an important prognostic factor for poorer survival time of breast cancer patients.

Show MeSH

Related in: MedlinePlus

Low expression of C10orf10 is correlated with shorter survival in BC patients from KM plotter with ER positive and lymph node negative.(A) Survival analysis of C10orf10 expression in 377 BC patients with ER positive. Auto select best cutoff was chosen in the analysis; Cutoff value used was 1117; Expression range of the probe was 143–3356. (B) Survival analysis of C10orf10 expression in 424 BC patients with lymph node negative. Auto select best cutoff was chosen in the analysis; Cutoff value used was 923; Expression range of the probe was 143–3356.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4061027&req=5

pone-0099730-g005: Low expression of C10orf10 is correlated with shorter survival in BC patients from KM plotter with ER positive and lymph node negative.(A) Survival analysis of C10orf10 expression in 377 BC patients with ER positive. Auto select best cutoff was chosen in the analysis; Cutoff value used was 1117; Expression range of the probe was 143–3356. (B) Survival analysis of C10orf10 expression in 424 BC patients with lymph node negative. Auto select best cutoff was chosen in the analysis; Cutoff value used was 923; Expression range of the probe was 143–3356.

Mentions: Now there is still a compelling question that whether low expression of C10orf10 also predict poorer survival of the BC patients with different lymph node statuses and ER statuses. We observed a statistically effect of low C10orf10 expression on the poorer survival of the BC patients who were lymph node negative (HR = 0.66, P = 0.048) and ER positive (HR = 0.61, P = 0.021) (Figure 5A, 5B), but no effect on that of the patients who were lymph node positive (HR = 0.63, P = 0.089) and ER negative (HR = 0.62, P = 0.095).


Decreased expression of C10orf10 and its prognostic significance in human breast cancer.

Deng J, Dong Y, Li C, Zuo W, Meng G, Xu C, Li J - PLoS ONE (2014)

Low expression of C10orf10 is correlated with shorter survival in BC patients from KM plotter with ER positive and lymph node negative.(A) Survival analysis of C10orf10 expression in 377 BC patients with ER positive. Auto select best cutoff was chosen in the analysis; Cutoff value used was 1117; Expression range of the probe was 143–3356. (B) Survival analysis of C10orf10 expression in 424 BC patients with lymph node negative. Auto select best cutoff was chosen in the analysis; Cutoff value used was 923; Expression range of the probe was 143–3356.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4061027&req=5

pone-0099730-g005: Low expression of C10orf10 is correlated with shorter survival in BC patients from KM plotter with ER positive and lymph node negative.(A) Survival analysis of C10orf10 expression in 377 BC patients with ER positive. Auto select best cutoff was chosen in the analysis; Cutoff value used was 1117; Expression range of the probe was 143–3356. (B) Survival analysis of C10orf10 expression in 424 BC patients with lymph node negative. Auto select best cutoff was chosen in the analysis; Cutoff value used was 923; Expression range of the probe was 143–3356.
Mentions: Now there is still a compelling question that whether low expression of C10orf10 also predict poorer survival of the BC patients with different lymph node statuses and ER statuses. We observed a statistically effect of low C10orf10 expression on the poorer survival of the BC patients who were lymph node negative (HR = 0.66, P = 0.048) and ER positive (HR = 0.61, P = 0.021) (Figure 5A, 5B), but no effect on that of the patients who were lymph node positive (HR = 0.63, P = 0.089) and ER negative (HR = 0.62, P = 0.095).

Bottom Line: Here, we identified C10orf10 as a novel differentially expression gene using expression microarray screening.Kaplan-Meier analysis indicated that patients with low C10orf10 expression showed a poorer prognosis both in mRNA (n = 1115, P = 0.0013) and protein (n = 100, P = 0.003) levels.Further analysis revealed that low expression of C10orf10 was an unfavorable factor for the prognosis of the patients who were luminal A, luminal B, Her2+ subtypes, at histological grade 2, lymph node negative and ER positive.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing, China; Cadre's Sanatorium, Third Military Medical University, Chongqing, China.

ABSTRACT
Breast cancer is a common malignant tumor, which severely threatens the health of women with an increasing incidence in many countries. Here, we identified C10orf10 as a novel differentially expression gene using expression microarray screening. The expression analysis indicated that C10orf10 was frequently decreased in human breast cancers compared to noncancerous breast tissues (81/95, P = 0.0063). Kaplan-Meier analysis indicated that patients with low C10orf10 expression showed a poorer prognosis both in mRNA (n = 1115, P = 0.0013) and protein (n = 100, P = 0.003) levels. Univariate and multivariate analysis showed that the C10orf10 expression was an independent prognostic factor for overall survival of breast cancer patients. Further analysis revealed that low expression of C10orf10 was an unfavorable factor for the prognosis of the patients who were luminal A, luminal B, Her2+ subtypes, at histological grade 2, lymph node negative and ER positive. Our data provided the first evidence that C10orf10 expression was frequently decreased in breast cancer tissues, and low expression of C10orf10 may be an important prognostic factor for poorer survival time of breast cancer patients.

Show MeSH
Related in: MedlinePlus