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Seroprevalence of HBV, HCV & HIV co-infection and risk factors analysis in Tripoli-Libya.

Daw MA, Shabash A, El-Bouzedi A, Dau AA, Association with the Libyan Study Group of Hepatitis & H - PLoS ONE (2014)

Bottom Line: HBV was more prevalent among those aged over 50 years and was associated with family history.High prevalence was associated with geographic, ethnic and socioeconomic variability within the community.Regulations and health care education need to be implemented and longer term follow-up should be planned.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, Faculty of Medicine, Tripoli, Libya; Department of Surgery, Tripoli Medical Centre, Faculty of Medicine, Tripoli, Libya.

ABSTRACT

Background: In 1998 Libya experienced a major outbreak of multiple blood borne viral hepatitis and HIV infections. Since then, no studies have been done on the epidemic features and risk factors of HBV, HCV, HIV and co-infection among the general population.

Methods: A prospective study was carried out using a multi-centre clustering method to collect samples from the general population. The participants were interviewed, and relevant information was collected, including socio-demographic, ethnic, and geographic variables. This information was correlated with the risk factors involved in the transmission of HBV, HCV and HIV. Blood samples were collected and the sera were tested for HBsAg, anti-HCV and anti-HIV using enzyme immunoassay.

Results: A total of 9,170 participants from the nine districts of Tripoli were enrolled. The average prevalence of HBsAg was 3.7%, anti-HCV 0.9%, anti-HIV 0.15% and co-infection 0.02%. The prevalence varied from one district to another. HBV was more prevalent among those aged over 50 years and was associated with family history. Anti-HCV and anti-HIV were more prevalent among those aged 20-40 years. Intravenous drug use and blood transfusion were the main risk factors for HCV and HIV infection.

Conclusion: HBV, HCV, HIV and co-infection are relatively common in Libya. High prevalence was associated with geographic, ethnic and socioeconomic variability within the community. HCV and HIV infections among the younger age groups are becoming an alarming issue. Regulations and health care education need to be implemented and longer term follow-up should be planned.

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Related in: MedlinePlus

Map of Tripoli showing the Location of 9 studied districts and Sero-prevalence of HBV, HCV and HIV among each district, Tripoli-Libya 2011.
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pone-0098793-g001: Map of Tripoli showing the Location of 9 studied districts and Sero-prevalence of HBV, HCV and HIV among each district, Tripoli-Libya 2011.

Mentions: The prevalence of the three viruses varied from one district to another (Figure 1). The overall prevalence of HBV was 3.7% (95% CI 3.6%–3.8%). The highest prevalence rates of HBsAg were in Abu Saleem district (5.2%), Alhadba and Souk Aljuma (4.75% each). It was less prevalent in the Old City (1.5%) followed by Qasr Ben Gashir (1.9%). The prevalence of HBV was 1.4 times higher among males.


Seroprevalence of HBV, HCV & HIV co-infection and risk factors analysis in Tripoli-Libya.

Daw MA, Shabash A, El-Bouzedi A, Dau AA, Association with the Libyan Study Group of Hepatitis & H - PLoS ONE (2014)

Map of Tripoli showing the Location of 9 studied districts and Sero-prevalence of HBV, HCV and HIV among each district, Tripoli-Libya 2011.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4060988&req=5

pone-0098793-g001: Map of Tripoli showing the Location of 9 studied districts and Sero-prevalence of HBV, HCV and HIV among each district, Tripoli-Libya 2011.
Mentions: The prevalence of the three viruses varied from one district to another (Figure 1). The overall prevalence of HBV was 3.7% (95% CI 3.6%–3.8%). The highest prevalence rates of HBsAg were in Abu Saleem district (5.2%), Alhadba and Souk Aljuma (4.75% each). It was less prevalent in the Old City (1.5%) followed by Qasr Ben Gashir (1.9%). The prevalence of HBV was 1.4 times higher among males.

Bottom Line: HBV was more prevalent among those aged over 50 years and was associated with family history.High prevalence was associated with geographic, ethnic and socioeconomic variability within the community.Regulations and health care education need to be implemented and longer term follow-up should be planned.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, Faculty of Medicine, Tripoli, Libya; Department of Surgery, Tripoli Medical Centre, Faculty of Medicine, Tripoli, Libya.

ABSTRACT

Background: In 1998 Libya experienced a major outbreak of multiple blood borne viral hepatitis and HIV infections. Since then, no studies have been done on the epidemic features and risk factors of HBV, HCV, HIV and co-infection among the general population.

Methods: A prospective study was carried out using a multi-centre clustering method to collect samples from the general population. The participants were interviewed, and relevant information was collected, including socio-demographic, ethnic, and geographic variables. This information was correlated with the risk factors involved in the transmission of HBV, HCV and HIV. Blood samples were collected and the sera were tested for HBsAg, anti-HCV and anti-HIV using enzyme immunoassay.

Results: A total of 9,170 participants from the nine districts of Tripoli were enrolled. The average prevalence of HBsAg was 3.7%, anti-HCV 0.9%, anti-HIV 0.15% and co-infection 0.02%. The prevalence varied from one district to another. HBV was more prevalent among those aged over 50 years and was associated with family history. Anti-HCV and anti-HIV were more prevalent among those aged 20-40 years. Intravenous drug use and blood transfusion were the main risk factors for HCV and HIV infection.

Conclusion: HBV, HCV, HIV and co-infection are relatively common in Libya. High prevalence was associated with geographic, ethnic and socioeconomic variability within the community. HCV and HIV infections among the younger age groups are becoming an alarming issue. Regulations and health care education need to be implemented and longer term follow-up should be planned.

Show MeSH
Related in: MedlinePlus