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Safety and tolerability of regadenoson CMR.

Nguyen KL, Bandettini WP, Shanbhag S, Leung SW, Wilson JR, Arai AE - Eur Heart J Cardiovasc Imaging (2014)

Bottom Line: Knowledge of adverse events associated with regadenoson perfusion cardiac magnetic resonance (CMR) and patient tolerability has implications for patient safety and staff training.We sought to assess the safety and tolerability of regadenoson stress CMR.Regadenoson CMR is well tolerated and can be performed safely with few adverse events.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive Bldg 10, Rm B1D416, MSC 1061, Bethesda, MD 20892-1061, USA Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.

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Regadenoson perfusion imaging protocol. sec (s), second (s); min (s), minute (s).
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JET278F1: Regadenoson perfusion imaging protocol. sec (s), second (s); min (s), minute (s).

Mentions: CMR imaging was performed using a 1.5 Tesla imaging system (Siemens Medical Solution, Erlangen, Germany). First-pass stress and rest perfusion images were obtained using a steady-state-free precession sequence (SSFP) (n = 706) (TR 2.5 ms, TE 1.04 ms, flip angle 50°, voxel size 3 × 3 × 8 mm, bandwidth 1085 Hz/pixel) or a gradient spoiled echo sequence (n = 22) (TR 2.17 ms, TE 1.03 ms, flip angle 12°, voxel size 3 × 3 × 8 mm, bandwidth 651 Hz/pixel). Gadolinium (Magnevist©, Gadopentetate Dimeglumine, Bayer Healthcare, Wayne, NJ, USA) 0.05 mmol/kg body weight was given at 5 mL/s for both stress and rest image acquisition. Depending on the heart rate (HR), either three or four left ventricular short-axis slices (base, mid-ventricle, and apex) were obtained. SSFP cine images were obtained during the 20-min post-stress period (TR 2.90 ms, TE 1.19 ms, flip angle 50°, voxel size 1 × 1 × 6 mm, bandwidth 930 Hz/ pixel). Late gadolinium enhancement images were acquired using a phase sensitive inversion recovery fast gradient echo sequence (TR 8.3 ms, TE 3.25 ms, TI individualized to the myocardium, flip angle 25°, voxel size 1 × 1 × 6 mm, bandwidth 140 Hz/ pixel) (Figure 1).Figure 1


Safety and tolerability of regadenoson CMR.

Nguyen KL, Bandettini WP, Shanbhag S, Leung SW, Wilson JR, Arai AE - Eur Heart J Cardiovasc Imaging (2014)

Regadenoson perfusion imaging protocol. sec (s), second (s); min (s), minute (s).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4060784&req=5

JET278F1: Regadenoson perfusion imaging protocol. sec (s), second (s); min (s), minute (s).
Mentions: CMR imaging was performed using a 1.5 Tesla imaging system (Siemens Medical Solution, Erlangen, Germany). First-pass stress and rest perfusion images were obtained using a steady-state-free precession sequence (SSFP) (n = 706) (TR 2.5 ms, TE 1.04 ms, flip angle 50°, voxel size 3 × 3 × 8 mm, bandwidth 1085 Hz/pixel) or a gradient spoiled echo sequence (n = 22) (TR 2.17 ms, TE 1.03 ms, flip angle 12°, voxel size 3 × 3 × 8 mm, bandwidth 651 Hz/pixel). Gadolinium (Magnevist©, Gadopentetate Dimeglumine, Bayer Healthcare, Wayne, NJ, USA) 0.05 mmol/kg body weight was given at 5 mL/s for both stress and rest image acquisition. Depending on the heart rate (HR), either three or four left ventricular short-axis slices (base, mid-ventricle, and apex) were obtained. SSFP cine images were obtained during the 20-min post-stress period (TR 2.90 ms, TE 1.19 ms, flip angle 50°, voxel size 1 × 1 × 6 mm, bandwidth 930 Hz/ pixel). Late gadolinium enhancement images were acquired using a phase sensitive inversion recovery fast gradient echo sequence (TR 8.3 ms, TE 3.25 ms, TI individualized to the myocardium, flip angle 25°, voxel size 1 × 1 × 6 mm, bandwidth 140 Hz/ pixel) (Figure 1).Figure 1

Bottom Line: Knowledge of adverse events associated with regadenoson perfusion cardiac magnetic resonance (CMR) and patient tolerability has implications for patient safety and staff training.We sought to assess the safety and tolerability of regadenoson stress CMR.Regadenoson CMR is well tolerated and can be performed safely with few adverse events.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive Bldg 10, Rm B1D416, MSC 1061, Bethesda, MD 20892-1061, USA Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.

Show MeSH
Related in: MedlinePlus