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In silico molecular docking and in vitro antidiabetic studies of dihydropyrimido[4,5-a]acridin-2-amines.

Bharathi A, Roopan SM, Vasavi CS, Munusami P, Gayathri GA, Gayathri M - Biomed Res Int (2014)

Bottom Line: An in vitro antidiabetic activity on α -amylase and α -glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a-3f) were evaluated.An in silico molecular docking was performed on synthesized molecules (3a-3f).Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α -amylase and α -glucosidase.

View Article: PubMed Central - PubMed

Affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu 632 014, India.

ABSTRACT
An in vitro antidiabetic activity on α -amylase and α -glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a-3f) were evaluated. Structures of the synthesized molecules were studied by FT-IR, (1)H NMR, (13)C NMR, EI-MS, and single crystal X-ray structural analysis data. An in silico molecular docking was performed on synthesized molecules (3a-3f). Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α -amylase and α -glucosidase.

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% of relative movement in glucose diffusion inhibitory assay.
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fig5: % of relative movement in glucose diffusion inhibitory assay.

Mentions: The results are summarized in Tables 4 and 5. The diffused glucose concentration is given in Table 4 and % of relative movement is given in Table 5. The movement of glucose from inside of membrane to external solution monitored and compared in Figures 4 and 5. Among the six samples only the 3e retains the glucose and shows minimum % of relative movement 41.06% over 180 minutes. All other samples show the highest % of relative movement in glucose diffusion from 30 to 180 minutes.


In silico molecular docking and in vitro antidiabetic studies of dihydropyrimido[4,5-a]acridin-2-amines.

Bharathi A, Roopan SM, Vasavi CS, Munusami P, Gayathri GA, Gayathri M - Biomed Res Int (2014)

% of relative movement in glucose diffusion inhibitory assay.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4060768&req=5

fig5: % of relative movement in glucose diffusion inhibitory assay.
Mentions: The results are summarized in Tables 4 and 5. The diffused glucose concentration is given in Table 4 and % of relative movement is given in Table 5. The movement of glucose from inside of membrane to external solution monitored and compared in Figures 4 and 5. Among the six samples only the 3e retains the glucose and shows minimum % of relative movement 41.06% over 180 minutes. All other samples show the highest % of relative movement in glucose diffusion from 30 to 180 minutes.

Bottom Line: An in vitro antidiabetic activity on α -amylase and α -glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a-3f) were evaluated.An in silico molecular docking was performed on synthesized molecules (3a-3f).Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α -amylase and α -glucosidase.

View Article: PubMed Central - PubMed

Affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu 632 014, India.

ABSTRACT
An in vitro antidiabetic activity on α -amylase and α -glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a-3f) were evaluated. Structures of the synthesized molecules were studied by FT-IR, (1)H NMR, (13)C NMR, EI-MS, and single crystal X-ray structural analysis data. An in silico molecular docking was performed on synthesized molecules (3a-3f). Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α -amylase and α -glucosidase.

Show MeSH
Related in: MedlinePlus