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Effect of swimming on clinical functional parameters and serum biomarkers in healthy and osteoarthritic dogs.

Nganvongpanit K, Tanvisut S, Yano T, Kongtawelert P - ISRN Vet Sci (2014)

Bottom Line: Clinical evaluation of the OA-SW group found that most parameters showed improvement (P < 0.01) at week 8 compared to pretreatment, while pain on palpation was improved (P < 0.01) at week 6.The relative level of serum CS-WF6 in the OA-SW group was found to be significantly different (P < 0.01) at weeks 6 and 8 compared with the preexercise.The levels of serum HA of the H-SW group in weeks 2-8 were significantly (P < 0.01) higher than preexercise.

View Article: PubMed Central - PubMed

Affiliation: Animals Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand.

ABSTRACT
This study aimed to determine whether swimming could improve function of osteoarthritic joints in canine hip OA. Fifty-five dogs were categorized into three groups. The OA with swimming group (OA-SW; n = 22), the healthy (non-OA; n = 18) with swimming group (H-SW), and the healthy (non-OA; n = 15) without swimming group (H-NSW). All animals were allowed to swim for a total of 8 weeks (2-day period, 3 cycles of swimming for 20 minutes, and resting period for 5 minutes in each cycle). Three ml of blood was collected every 2 weeks for evaluation of the levels of biomarkers for OA, including chondroitin sulfate epitope WF6 (CS-WF6) and hyaluronan (HA). Clinical evaluation of the OA-SW group found that most parameters showed improvement (P < 0.01) at week 8 compared to pretreatment, while pain on palpation was improved (P < 0.01) at week 6. The relative level of serum CS-WF6 in the OA-SW group was found to be significantly different (P < 0.01) at weeks 6 and 8 compared with the preexercise. The levels of serum HA of the H-SW group in weeks 2-8 were significantly (P < 0.01) higher than preexercise. Conclusion, swimming over 2-day period, 8 weeks continually, can improve the function of OA joint.

No MeSH data available.


Related in: MedlinePlus

Mean (±SD) scores of radiographic images. The values were not significantly different between 0 and 8 weeks (P > 0.05).
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fig2: Mean (±SD) scores of radiographic images. The values were not significantly different between 0 and 8 weeks (P > 0.05).

Mentions: All 22 dogs in the OA-SW group had been diagnosed with OA of the hip joint and were classified as grade 1.95 ± 0.67 via a radiographic scoring system. Two biomarkers (CS-WF6 and HA) were also used to confirm OA by comparing OA and non-OA groups (Figure 1). The OA group showed significantly (P < 0.05) lower HA (31.25 ± 18.52) and higher CS-WF6 (83.91 ± 35.64) levels compared to the non-OA group (HA = 70.42 ± 27.97 and WF6 = 29.79 ± 24.66). The relative level of serum CS-WF6 in the OA-SW group was dramatically decreased beginning at week 4 (90.52 ± 31.02), but it was found to be significantly different (P < 0.05) compared with preexercise (100) level at weeks 6 (64.44 ± 23.16) and 8 (40.68 ± 19.71). On the other hand, the relative expression of serum CS-WF6 in the other two groups (H-SW and H-NSW) showed no significant change over the 8-week exercise period (Figure 2). The relative level of serum HA in the OA-SW group increased beginning at week 2 (137.50 ± 39.39) and then continued to rise steadily: at week 4, 166.60 ± 69.09; week 6, 257.75 ± 94.83; and at the end of week 8, 470.88 ± 286.96. Moreover, the levels of serum HA of the H-SW group were significantly (P < 0.05) higher than preexercise level: at week 2, 169.44 ± 102.44; week 4, 165.06 ± 55.87; week 6, 164.39 ± 75.28; and at the end of week 8, 164.39 ± 29.68 (Figure 3).


Effect of swimming on clinical functional parameters and serum biomarkers in healthy and osteoarthritic dogs.

Nganvongpanit K, Tanvisut S, Yano T, Kongtawelert P - ISRN Vet Sci (2014)

Mean (±SD) scores of radiographic images. The values were not significantly different between 0 and 8 weeks (P > 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4060742&req=5

fig2: Mean (±SD) scores of radiographic images. The values were not significantly different between 0 and 8 weeks (P > 0.05).
Mentions: All 22 dogs in the OA-SW group had been diagnosed with OA of the hip joint and were classified as grade 1.95 ± 0.67 via a radiographic scoring system. Two biomarkers (CS-WF6 and HA) were also used to confirm OA by comparing OA and non-OA groups (Figure 1). The OA group showed significantly (P < 0.05) lower HA (31.25 ± 18.52) and higher CS-WF6 (83.91 ± 35.64) levels compared to the non-OA group (HA = 70.42 ± 27.97 and WF6 = 29.79 ± 24.66). The relative level of serum CS-WF6 in the OA-SW group was dramatically decreased beginning at week 4 (90.52 ± 31.02), but it was found to be significantly different (P < 0.05) compared with preexercise (100) level at weeks 6 (64.44 ± 23.16) and 8 (40.68 ± 19.71). On the other hand, the relative expression of serum CS-WF6 in the other two groups (H-SW and H-NSW) showed no significant change over the 8-week exercise period (Figure 2). The relative level of serum HA in the OA-SW group increased beginning at week 2 (137.50 ± 39.39) and then continued to rise steadily: at week 4, 166.60 ± 69.09; week 6, 257.75 ± 94.83; and at the end of week 8, 470.88 ± 286.96. Moreover, the levels of serum HA of the H-SW group were significantly (P < 0.05) higher than preexercise level: at week 2, 169.44 ± 102.44; week 4, 165.06 ± 55.87; week 6, 164.39 ± 75.28; and at the end of week 8, 164.39 ± 29.68 (Figure 3).

Bottom Line: Clinical evaluation of the OA-SW group found that most parameters showed improvement (P < 0.01) at week 8 compared to pretreatment, while pain on palpation was improved (P < 0.01) at week 6.The relative level of serum CS-WF6 in the OA-SW group was found to be significantly different (P < 0.01) at weeks 6 and 8 compared with the preexercise.The levels of serum HA of the H-SW group in weeks 2-8 were significantly (P < 0.01) higher than preexercise.

View Article: PubMed Central - PubMed

Affiliation: Animals Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand.

ABSTRACT
This study aimed to determine whether swimming could improve function of osteoarthritic joints in canine hip OA. Fifty-five dogs were categorized into three groups. The OA with swimming group (OA-SW; n = 22), the healthy (non-OA; n = 18) with swimming group (H-SW), and the healthy (non-OA; n = 15) without swimming group (H-NSW). All animals were allowed to swim for a total of 8 weeks (2-day period, 3 cycles of swimming for 20 minutes, and resting period for 5 minutes in each cycle). Three ml of blood was collected every 2 weeks for evaluation of the levels of biomarkers for OA, including chondroitin sulfate epitope WF6 (CS-WF6) and hyaluronan (HA). Clinical evaluation of the OA-SW group found that most parameters showed improvement (P < 0.01) at week 8 compared to pretreatment, while pain on palpation was improved (P < 0.01) at week 6. The relative level of serum CS-WF6 in the OA-SW group was found to be significantly different (P < 0.01) at weeks 6 and 8 compared with the preexercise. The levels of serum HA of the H-SW group in weeks 2-8 were significantly (P < 0.01) higher than preexercise. Conclusion, swimming over 2-day period, 8 weeks continually, can improve the function of OA joint.

No MeSH data available.


Related in: MedlinePlus