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Incidence and cost of hospitalizations associated with Staphylococcus aureus skin and soft tissue infections in the United States from 2001 through 2009.

Suaya JA, Mera RM, Cassidy A, O'Hara P, Amrine-Madsen H, Burstin S, Miller LG - BMC Infect. Dis. (2014)

Bottom Line: A significant increase was observed in all age groups.In 2009, the average associated cost of a SA-SSTI hospitalization was $11,622 (SE=$200).There has been an increase in the incidence and associated cost of SA-SSTI hospitalizations in U.S.A. between 2001 and 2009, with the highest incidence increase seen in children 0-17 years.

View Article: PubMed Central - HTML - PubMed

Affiliation: Health Outcomes, North America Vaccine Development, GlaxoSmithKline, Philadelphia, PA, USA. Jose.2.Suaya@gsk.com.

ABSTRACT

Background: The emergence of community-associated methicillin-resistant Staphylococcus aureus (SA) and its role in skin and soft tissue infections (SSTIs) accentuated the role of SA-SSTIs in hospitalizations.

Methods: We used the Nationwide Inpatient Sample and Census Bureau data to quantify population-based incidence and associated cost for SA-SSTI hospitalizations.

Results: SA-SSTI associated hospitalizations increased 123% from 160,811 to 358,212 between 2001 and 2009, and they represented an increasing share of SA- hospitalizations (39% to 51%). SA-SSTI incidence (per 100,000 people) doubled from 57 in 2001 to 117 in 2009 (p<0.01). A significant increase was observed in all age groups. Adults aged 75+ years and children 0-17 years experienced the lowest (27%) and highest (305%) incidence increase, respectively. However, the oldest age group still had the highest SA-SSTI hospitalization incidence across all study years. Total annual cost of SA-SSTI hospitalizations also increased and peaked in 2008 at $4.84 billion, a 44% increase from 2001. In 2009, the average associated cost of a SA-SSTI hospitalization was $11,622 (SE=$200).

Conclusion: There has been an increase in the incidence and associated cost of SA-SSTI hospitalizations in U.S.A. between 2001 and 2009, with the highest incidence increase seen in children 0-17 years. However, the greatest burden was still seen in the population over 75 years. By 2009, SSTI diagnoses were present in about half of all SA-hospitalizations.

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Incidence of S. aureus hospitalizations overall and those associated with skin and soft tissue infection (SSTI) in U.S.A., 2001–2009.
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Figure 1: Incidence of S. aureus hospitalizations overall and those associated with skin and soft tissue infection (SSTI) in U.S.A., 2001–2009.

Mentions: From 2001 through 2009, hospitalizations associated with any S. aureus infection increased from 410,768 to 697,248 hospitalizations, a 70% increase (p < 0.001). During our study period, the peak year for S. aureus and S. aureus-SSTI hospitalizations was 2008, with a subsequent non-significant decrease in 2009. During the same period, the total number of hospitalizations for any reason increased non-significantly by 6% (37.2 to 39.4 million). Among all S. aureus associated hospitalizations, SSTIs comprised an increasing proportion over time (39% in 2001 to 51% in 2009, p < 0.01) (Table 1 and Figure 1). Whilst the incidence of any S. aureus hospitalization increased by 57% between 2001 and 2009 (from 145 to 228 per 100,000, p < 0.01), the incidence of S. aureus-SSTIs increased by 105% in the same period (from 57 to 117 per 100,000, p < 0.01) (Figure 1).


Incidence and cost of hospitalizations associated with Staphylococcus aureus skin and soft tissue infections in the United States from 2001 through 2009.

Suaya JA, Mera RM, Cassidy A, O'Hara P, Amrine-Madsen H, Burstin S, Miller LG - BMC Infect. Dis. (2014)

Incidence of S. aureus hospitalizations overall and those associated with skin and soft tissue infection (SSTI) in U.S.A., 2001–2009.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4060579&req=5

Figure 1: Incidence of S. aureus hospitalizations overall and those associated with skin and soft tissue infection (SSTI) in U.S.A., 2001–2009.
Mentions: From 2001 through 2009, hospitalizations associated with any S. aureus infection increased from 410,768 to 697,248 hospitalizations, a 70% increase (p < 0.001). During our study period, the peak year for S. aureus and S. aureus-SSTI hospitalizations was 2008, with a subsequent non-significant decrease in 2009. During the same period, the total number of hospitalizations for any reason increased non-significantly by 6% (37.2 to 39.4 million). Among all S. aureus associated hospitalizations, SSTIs comprised an increasing proportion over time (39% in 2001 to 51% in 2009, p < 0.01) (Table 1 and Figure 1). Whilst the incidence of any S. aureus hospitalization increased by 57% between 2001 and 2009 (from 145 to 228 per 100,000, p < 0.01), the incidence of S. aureus-SSTIs increased by 105% in the same period (from 57 to 117 per 100,000, p < 0.01) (Figure 1).

Bottom Line: A significant increase was observed in all age groups.In 2009, the average associated cost of a SA-SSTI hospitalization was $11,622 (SE=$200).There has been an increase in the incidence and associated cost of SA-SSTI hospitalizations in U.S.A. between 2001 and 2009, with the highest incidence increase seen in children 0-17 years.

View Article: PubMed Central - HTML - PubMed

Affiliation: Health Outcomes, North America Vaccine Development, GlaxoSmithKline, Philadelphia, PA, USA. Jose.2.Suaya@gsk.com.

ABSTRACT

Background: The emergence of community-associated methicillin-resistant Staphylococcus aureus (SA) and its role in skin and soft tissue infections (SSTIs) accentuated the role of SA-SSTIs in hospitalizations.

Methods: We used the Nationwide Inpatient Sample and Census Bureau data to quantify population-based incidence and associated cost for SA-SSTI hospitalizations.

Results: SA-SSTI associated hospitalizations increased 123% from 160,811 to 358,212 between 2001 and 2009, and they represented an increasing share of SA- hospitalizations (39% to 51%). SA-SSTI incidence (per 100,000 people) doubled from 57 in 2001 to 117 in 2009 (p<0.01). A significant increase was observed in all age groups. Adults aged 75+ years and children 0-17 years experienced the lowest (27%) and highest (305%) incidence increase, respectively. However, the oldest age group still had the highest SA-SSTI hospitalization incidence across all study years. Total annual cost of SA-SSTI hospitalizations also increased and peaked in 2008 at $4.84 billion, a 44% increase from 2001. In 2009, the average associated cost of a SA-SSTI hospitalization was $11,622 (SE=$200).

Conclusion: There has been an increase in the incidence and associated cost of SA-SSTI hospitalizations in U.S.A. between 2001 and 2009, with the highest incidence increase seen in children 0-17 years. However, the greatest burden was still seen in the population over 75 years. By 2009, SSTI diagnoses were present in about half of all SA-hospitalizations.

Show MeSH
Related in: MedlinePlus