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NMR cryoporometry characterisation studies of the relation between drug release profile and pore structural evolution of polymeric nanoparticles.

Gopinathan N, Yang B, Lowe JP, Edler KJ, Rigby SP - Int J Pharm (2014)

Bottom Line: PLGA/PLA polymeric nanoparticles could potentially enhance the effectiveness of convective delivery of drugs, such as carboplatin, to the brain, by enabling a more sustained dosage over a longer time than otherwise possible.For a core-coat nanoparticle formulation, the development of smaller nanopores, following an extended induction period with no structural change, was associated with the onset of substantial drug release.Hence, the specific reasons for the effectiveness of the synthesis route, for obtaining core-coat nanoparticles with delayed release, have been elucidated.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

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(a) TEM images of nanoparticles from batch B negatively stained with phosphotungstic acid. ESEM (b) and TEM (c) of polymer nanoparticles from batch C. The images were obtained after preparing a suspension of nanoparticles in water. The images show the size and morphology of the nanoparticles.
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fig0025: (a) TEM images of nanoparticles from batch B negatively stained with phosphotungstic acid. ESEM (b) and TEM (c) of polymer nanoparticles from batch C. The images were obtained after preparing a suspension of nanoparticles in water. The images show the size and morphology of the nanoparticles.

Mentions: It is also noted that the melting profiles obtained for batches A and B are very similar in shape over the time intervals studied. Fig. 5(a) shows a TEM image of nanoparticles from batch B. It can be seen that they have a round morphology.


NMR cryoporometry characterisation studies of the relation between drug release profile and pore structural evolution of polymeric nanoparticles.

Gopinathan N, Yang B, Lowe JP, Edler KJ, Rigby SP - Int J Pharm (2014)

(a) TEM images of nanoparticles from batch B negatively stained with phosphotungstic acid. ESEM (b) and TEM (c) of polymer nanoparticles from batch C. The images were obtained after preparing a suspension of nanoparticles in water. The images show the size and morphology of the nanoparticles.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048935&req=5

fig0025: (a) TEM images of nanoparticles from batch B negatively stained with phosphotungstic acid. ESEM (b) and TEM (c) of polymer nanoparticles from batch C. The images were obtained after preparing a suspension of nanoparticles in water. The images show the size and morphology of the nanoparticles.
Mentions: It is also noted that the melting profiles obtained for batches A and B are very similar in shape over the time intervals studied. Fig. 5(a) shows a TEM image of nanoparticles from batch B. It can be seen that they have a round morphology.

Bottom Line: PLGA/PLA polymeric nanoparticles could potentially enhance the effectiveness of convective delivery of drugs, such as carboplatin, to the brain, by enabling a more sustained dosage over a longer time than otherwise possible.For a core-coat nanoparticle formulation, the development of smaller nanopores, following an extended induction period with no structural change, was associated with the onset of substantial drug release.Hence, the specific reasons for the effectiveness of the synthesis route, for obtaining core-coat nanoparticles with delayed release, have been elucidated.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

Show MeSH