NMR cryoporometry characterisation studies of the relation between drug release profile and pore structural evolution of polymeric nanoparticles.
Bottom Line: PLGA/PLA polymeric nanoparticles could potentially enhance the effectiveness of convective delivery of drugs, such as carboplatin, to the brain, by enabling a more sustained dosage over a longer time than otherwise possible.For a core-coat nanoparticle formulation, the development of smaller nanopores, following an extended induction period with no structural change, was associated with the onset of substantial drug release.Hence, the specific reasons for the effectiveness of the synthesis route, for obtaining core-coat nanoparticles with delayed release, have been elucidated.
Affiliation: Department of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK.Show MeSH
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Mentions: NMR cryoporometry was used to study the pore structural evolution of polymer nanoparticles from batch B immersed in aCSF. Fig. 4 presents the melting profile of aCSF solution containing the nanoparticles from batch B. The melting profiles were obtained after ∼1 and ∼2 days of incubation. Fig. 4 also shows the carboplatin drug release profile for these nanoparticles. The individual symbols situated at various points along the release profile correspond to the times at which the melting profiles (displayed with same symbol shape) were obtained. It was found that ∼98.9% of the drug was released in 24 h and over the next 48 h there was only a ∼1% increase in the drug released. The melting profiles of the solution containing nanoparticles after ∼1 and ∼2 days of incubation were found to be very similar showing very little increase in pore volume over the period investigated. The data obtained after 2 days, shown in Fig. 4, are located above the data obtained after 1 day of incubation. It was also noted that the step present in the melting curve for the bulk solution at a temperature of ∼250–1 K was absent in the data for the solution containing nanoparticles (similar to batch A seen previously). Instead the melting profile was smooth and broad over the entire temperature range.
Affiliation: Department of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK.