NMR cryoporometry characterisation studies of the relation between drug release profile and pore structural evolution of polymeric nanoparticles.
Bottom Line: PLGA/PLA polymeric nanoparticles could potentially enhance the effectiveness of convective delivery of drugs, such as carboplatin, to the brain, by enabling a more sustained dosage over a longer time than otherwise possible.For a core-coat nanoparticle formulation, the development of smaller nanopores, following an extended induction period with no structural change, was associated with the onset of substantial drug release.Hence, the specific reasons for the effectiveness of the synthesis route, for obtaining core-coat nanoparticles with delayed release, have been elucidated.
Affiliation: Department of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK.Show MeSH
Mentions: The ESEM images provided a qualitative understanding of the interaction between water vapour and the nanoparticle aggregate structure during short time intervals. However, the NMR cryoporometry technique was used to study the evolution of the particle nanoscale structure, following immersion in aCSF, over longer time intervals. Evolution of the nanoparticle structure would be evident from any visible shifts in the melting profile of the probe fluid. As longer time scales were of interest, the melting profiles of aCSF solution containing nanoparticles belonging to batch A were obtained periodically after 1, 2 and 3 day(s) of incubation at 309.7 K. Fig. 3 presents the melting profiles of aCSF solution containing nanoparticles of batch A. The melting curves obtained after ∼1 day, ∼2 days, and ∼3 days of incubation showed no significant difference from each other.
Affiliation: Department of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK.