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Hydrogen sulfide to the rescue in obstructive kidney injury.

Kasinath BS - Kidney Int. (2014)

Bottom Line: Hydrogen sulfide is a gasotransmitter with far-reaching effects on cell function.Studies show that, depending on the context, hydrogen sulfide can function as an ameliorative agent or as a mediator of kidney injury.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio, Texas, USA.

ABSTRACT
Hydrogen sulfide is a gasotransmitter with far-reaching effects on cell function. Studies show that, depending on the context, hydrogen sulfide can function as an ameliorative agent or as a mediator of kidney injury.

Show MeSH

Related in: MedlinePlus

Hydrogen sulfide - synthesis, degradation and cellular effects 142×145mm (600 × 600 DPI)
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Figure 1: Hydrogen sulfide - synthesis, degradation and cellular effects 142×145mm (600 × 600 DPI)

Mentions: Hydrogen sulfide is constitutively produced in mammals by both enzymatic and non-enzymatic pathways (2). Three enzymes are mainly involved in hydrogen sulfide synthesis: CSE, cystathionine β synthase (CBS), and, 3-mercaptopyruvate sulfurtransferase (MST) (Fig. 1). Both CSE and CBS are dependent on pyridoxal phosphate for hydrogen sulfide generation whereas MST is not. CBS catalyzes the generation of cystathionine from L-homocysteine. CSE and CBS promote hydrogen sulfide synthesis from L-cysteine. CSE also catalyzes the conversion of cystathionine to L-cysteine. Coordinated activity of cysteine aminotransferase and MST is involved in sequential generation of 3-mercaptopyruvate and hydrogen sulfide, respectively (Fig. 1). MST is involved in mitochondrial generation of hydrogen sulfide. Non-enzymatic pathways can generate hydrogen sulfide from glucose, thiocystine and thiosulfate (2). Hydrogen sulfide exists in cellular bioavailable pools as free sulfide or as acid labile and bound sulfide (2). Cellular redox status and acidic pH may be able to mobilize hydrogen sulfide from these pools for physiologic actions. Metabolic fate of hydrogen sulfide includes conversion to thiosulfate, sulfite and sulfate, or, thiocyanate, or, methanethiol and dimethyl sulfide; these reactions are catalyzed by specific enzymes (2). Precise assays for measurement of H2S in biological samples are currently a subject of debate (2).


Hydrogen sulfide to the rescue in obstructive kidney injury.

Kasinath BS - Kidney Int. (2014)

Hydrogen sulfide - synthesis, degradation and cellular effects 142×145mm (600 × 600 DPI)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048854&req=5

Figure 1: Hydrogen sulfide - synthesis, degradation and cellular effects 142×145mm (600 × 600 DPI)
Mentions: Hydrogen sulfide is constitutively produced in mammals by both enzymatic and non-enzymatic pathways (2). Three enzymes are mainly involved in hydrogen sulfide synthesis: CSE, cystathionine β synthase (CBS), and, 3-mercaptopyruvate sulfurtransferase (MST) (Fig. 1). Both CSE and CBS are dependent on pyridoxal phosphate for hydrogen sulfide generation whereas MST is not. CBS catalyzes the generation of cystathionine from L-homocysteine. CSE and CBS promote hydrogen sulfide synthesis from L-cysteine. CSE also catalyzes the conversion of cystathionine to L-cysteine. Coordinated activity of cysteine aminotransferase and MST is involved in sequential generation of 3-mercaptopyruvate and hydrogen sulfide, respectively (Fig. 1). MST is involved in mitochondrial generation of hydrogen sulfide. Non-enzymatic pathways can generate hydrogen sulfide from glucose, thiocystine and thiosulfate (2). Hydrogen sulfide exists in cellular bioavailable pools as free sulfide or as acid labile and bound sulfide (2). Cellular redox status and acidic pH may be able to mobilize hydrogen sulfide from these pools for physiologic actions. Metabolic fate of hydrogen sulfide includes conversion to thiosulfate, sulfite and sulfate, or, thiocyanate, or, methanethiol and dimethyl sulfide; these reactions are catalyzed by specific enzymes (2). Precise assays for measurement of H2S in biological samples are currently a subject of debate (2).

Bottom Line: Hydrogen sulfide is a gasotransmitter with far-reaching effects on cell function.Studies show that, depending on the context, hydrogen sulfide can function as an ameliorative agent or as a mediator of kidney injury.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio, Texas, USA.

ABSTRACT
Hydrogen sulfide is a gasotransmitter with far-reaching effects on cell function. Studies show that, depending on the context, hydrogen sulfide can function as an ameliorative agent or as a mediator of kidney injury.

Show MeSH
Related in: MedlinePlus