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Incidence, histopathologic analysis and distribution of tumours of the hand.

Simon MJ, Pogoda P, Hövelborn F, Krause M, Zustin J, Amling M, Barvencik F - BMC Musculoskelet Disord (2014)

Bottom Line: The dominant tissue type found in phalanges and metacarpals was of cartilage origin.Osteogenic tumours were predominant in carpal bones.All primary skeletal tumours can be found in the hand and are most often of cartilage origin followed by bone cysts and osteogenic tumours.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistr, 52, 20246 Hamburg, Germany. amling@uke.de.

ABSTRACT

Background: The aim of this large collective and meticulous study of primary bone tumours and tumourous lesions of the hand was to enhance the knowledge about findings of traumatological radiographs and improve differential diagnosis.

Methods: This retrospective study reviewed data collected from 1976 until 2006 in our Bone Tumour Registry. The following data was documented: age, sex, radiological investigations, tumour location, histopathological features including type and dignity of the tumour, and diagnosis.

Results: The retrospective analysis yielded 631 patients with a mean age of 35.9 ± 19.2 years. The majority of primary hand tumours were found in the phalanges (69.7%) followed by 24.7% in metacarpals and 5.6% in the carpals. Only 10.6% of all cases were malignant. The major lesion type was cartilage derived at 69.1%, followed by bone cysts 11.3% and osteogenic tumours 8.7%. The dominant tissue type found in phalanges and metacarpals was of cartilage origin. Osteogenic tumours were predominant in carpal bones. Enchondroma was the most commonly detected tumour in the hand (47.1%).

Conclusions: All primary skeletal tumours can be found in the hand and are most often of cartilage origin followed by bone cysts and osteogenic tumours. This study furthermore raises awareness about uncommon or rare tumours and helps clinicians to establish proper differential diagnosis, as the majority of detected tumours of the hand are asymptomatic and accidental findings on radiographs.

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Primary bone tumours and tumourous lesions of the hand from the Bone Tumour Registry Hamburg from 1976 until 2006. Distribution of all cases per age decade with gender break down (A). Total of 320 tumour lesions were detected in men and 311 in women (B). Malignancies were found in 10.6% of all cases with an average age of 53.6 ± 24.3 years. Benign tumours were usually detected in younger patients (average age 33.8 ± 17.4 years) (C). Tumour lesions were divided into six groups: cartilage, bone cysts, osteogenic, vascular, fibrogenic and other tumours (D). Breakdown of tumour lesions into anatomical sites and malignant cases found in the specific site (E).
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Figure 1: Primary bone tumours and tumourous lesions of the hand from the Bone Tumour Registry Hamburg from 1976 until 2006. Distribution of all cases per age decade with gender break down (A). Total of 320 tumour lesions were detected in men and 311 in women (B). Malignancies were found in 10.6% of all cases with an average age of 53.6 ± 24.3 years. Benign tumours were usually detected in younger patients (average age 33.8 ± 17.4 years) (C). Tumour lesions were divided into six groups: cartilage, bone cysts, osteogenic, vascular, fibrogenic and other tumours (D). Breakdown of tumour lesions into anatomical sites and malignant cases found in the specific site (E).

Mentions: The retrospective analysis included 631 patients from 1976 until 2006 who met the inclusion criteria of a primary bone tumour confirmed by histopathologic analysis and not an osseous metastases, an inflammatory processes or of haematologic origin. The mean age was 35.9 ± 19.2 years. The distribution of tumour lesions in the right and left hand was 53.4 and 46.6 percent, respectively. The numbers of cases for each decade with additional separation by gender are illustrated in Figure 1 (Part A). The distribution by decade was significant according to the global chi-squared test. The gender break down revealed nearly equal occurrences: 50.7% for men and 49.3% for women (Figure 1B). Only 10.6% of all the registered tumours in our study were malignant (Figure 1C). Significant proportioning was found in the tumour tissue type classes with the cartilage-derived tumours being most dominant (69.1%, Figure 1D).


Incidence, histopathologic analysis and distribution of tumours of the hand.

Simon MJ, Pogoda P, Hövelborn F, Krause M, Zustin J, Amling M, Barvencik F - BMC Musculoskelet Disord (2014)

Primary bone tumours and tumourous lesions of the hand from the Bone Tumour Registry Hamburg from 1976 until 2006. Distribution of all cases per age decade with gender break down (A). Total of 320 tumour lesions were detected in men and 311 in women (B). Malignancies were found in 10.6% of all cases with an average age of 53.6 ± 24.3 years. Benign tumours were usually detected in younger patients (average age 33.8 ± 17.4 years) (C). Tumour lesions were divided into six groups: cartilage, bone cysts, osteogenic, vascular, fibrogenic and other tumours (D). Breakdown of tumour lesions into anatomical sites and malignant cases found in the specific site (E).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4048624&req=5

Figure 1: Primary bone tumours and tumourous lesions of the hand from the Bone Tumour Registry Hamburg from 1976 until 2006. Distribution of all cases per age decade with gender break down (A). Total of 320 tumour lesions were detected in men and 311 in women (B). Malignancies were found in 10.6% of all cases with an average age of 53.6 ± 24.3 years. Benign tumours were usually detected in younger patients (average age 33.8 ± 17.4 years) (C). Tumour lesions were divided into six groups: cartilage, bone cysts, osteogenic, vascular, fibrogenic and other tumours (D). Breakdown of tumour lesions into anatomical sites and malignant cases found in the specific site (E).
Mentions: The retrospective analysis included 631 patients from 1976 until 2006 who met the inclusion criteria of a primary bone tumour confirmed by histopathologic analysis and not an osseous metastases, an inflammatory processes or of haematologic origin. The mean age was 35.9 ± 19.2 years. The distribution of tumour lesions in the right and left hand was 53.4 and 46.6 percent, respectively. The numbers of cases for each decade with additional separation by gender are illustrated in Figure 1 (Part A). The distribution by decade was significant according to the global chi-squared test. The gender break down revealed nearly equal occurrences: 50.7% for men and 49.3% for women (Figure 1B). Only 10.6% of all the registered tumours in our study were malignant (Figure 1C). Significant proportioning was found in the tumour tissue type classes with the cartilage-derived tumours being most dominant (69.1%, Figure 1D).

Bottom Line: The dominant tissue type found in phalanges and metacarpals was of cartilage origin.Osteogenic tumours were predominant in carpal bones.All primary skeletal tumours can be found in the hand and are most often of cartilage origin followed by bone cysts and osteogenic tumours.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistr, 52, 20246 Hamburg, Germany. amling@uke.de.

ABSTRACT

Background: The aim of this large collective and meticulous study of primary bone tumours and tumourous lesions of the hand was to enhance the knowledge about findings of traumatological radiographs and improve differential diagnosis.

Methods: This retrospective study reviewed data collected from 1976 until 2006 in our Bone Tumour Registry. The following data was documented: age, sex, radiological investigations, tumour location, histopathological features including type and dignity of the tumour, and diagnosis.

Results: The retrospective analysis yielded 631 patients with a mean age of 35.9 ± 19.2 years. The majority of primary hand tumours were found in the phalanges (69.7%) followed by 24.7% in metacarpals and 5.6% in the carpals. Only 10.6% of all cases were malignant. The major lesion type was cartilage derived at 69.1%, followed by bone cysts 11.3% and osteogenic tumours 8.7%. The dominant tissue type found in phalanges and metacarpals was of cartilage origin. Osteogenic tumours were predominant in carpal bones. Enchondroma was the most commonly detected tumour in the hand (47.1%).

Conclusions: All primary skeletal tumours can be found in the hand and are most often of cartilage origin followed by bone cysts and osteogenic tumours. This study furthermore raises awareness about uncommon or rare tumours and helps clinicians to establish proper differential diagnosis, as the majority of detected tumours of the hand are asymptomatic and accidental findings on radiographs.

Show MeSH
Related in: MedlinePlus