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Antiosteoporotic effect of orally administered yolk-derived peptides on bone mass in women.

Abdou AM, Watabe K, Yamane T, Isono T, Okamura Y, Kawahito S, Takeshima K, Masuda K, Kim M - Food Sci Nutr (2014)

Bottom Line: The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years.After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups.Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.

View Article: PubMed Central - PubMed

Affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.

ABSTRACT
The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years. Subjects were divided into three groups, and then enrolled in a 6-month, randomized, double-blind clinical trial. Bone formation and resorption markers were measured at 0, 3, and 6 months, while bone mineral density (BMD) in the lumbar spines was measured at 0 and 6 months. Although the bone formation marker levels showed the similarity changes among the groups, bone resorption markers in the test HYP group were significantly decreased after 3 and 6 months in comparison to other groups (P < 0.05). After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups. Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.

No MeSH data available.


Related in: MedlinePlus

Tartarate-resistant acid phosphatase (TRAP) change rate (A) and N-telopeptide (NTx) change rate (B) in women (mean ± SEM) in WA-1, WA-2, and WA-3 groups after 0, 3, and 6 months.
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fig03: Tartarate-resistant acid phosphatase (TRAP) change rate (A) and N-telopeptide (NTx) change rate (B) in women (mean ± SEM) in WA-1, WA-2, and WA-3 groups after 0, 3, and 6 months.

Mentions: On the other hand, as shown in Figure 3A and Table 3, the bone resorption marker TRAP showed significantly decreased levels at the third month in WA-3 group compared to other two groups (P < 0.05). At the sixth month, there were also significant differences in TRAP levels in WA-3 and WA-2 groups compared to WA-1 group (P < 0.05). Bone resorption markers reflect osteoclast activity and/or collagen degradation. TRAP is an enzyme expressed when differentiating to osteoclast cells and also a sole direct-indicator of osteoclast numbers and bone resorption activity. So, TRAP is a bone resorption marker that was reported to be increased in patients with osteoporosis (Hochberg et al. 2002). The results of bone resorption markers suggest that HYP intake would have an antiosteoporotic effect that leads to better bone metabolism.


Antiosteoporotic effect of orally administered yolk-derived peptides on bone mass in women.

Abdou AM, Watabe K, Yamane T, Isono T, Okamura Y, Kawahito S, Takeshima K, Masuda K, Kim M - Food Sci Nutr (2014)

Tartarate-resistant acid phosphatase (TRAP) change rate (A) and N-telopeptide (NTx) change rate (B) in women (mean ± SEM) in WA-1, WA-2, and WA-3 groups after 0, 3, and 6 months.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048604&req=5

fig03: Tartarate-resistant acid phosphatase (TRAP) change rate (A) and N-telopeptide (NTx) change rate (B) in women (mean ± SEM) in WA-1, WA-2, and WA-3 groups after 0, 3, and 6 months.
Mentions: On the other hand, as shown in Figure 3A and Table 3, the bone resorption marker TRAP showed significantly decreased levels at the third month in WA-3 group compared to other two groups (P < 0.05). At the sixth month, there were also significant differences in TRAP levels in WA-3 and WA-2 groups compared to WA-1 group (P < 0.05). Bone resorption markers reflect osteoclast activity and/or collagen degradation. TRAP is an enzyme expressed when differentiating to osteoclast cells and also a sole direct-indicator of osteoclast numbers and bone resorption activity. So, TRAP is a bone resorption marker that was reported to be increased in patients with osteoporosis (Hochberg et al. 2002). The results of bone resorption markers suggest that HYP intake would have an antiosteoporotic effect that leads to better bone metabolism.

Bottom Line: The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years.After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups.Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.

View Article: PubMed Central - PubMed

Affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.

ABSTRACT
The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years. Subjects were divided into three groups, and then enrolled in a 6-month, randomized, double-blind clinical trial. Bone formation and resorption markers were measured at 0, 3, and 6 months, while bone mineral density (BMD) in the lumbar spines was measured at 0 and 6 months. Although the bone formation marker levels showed the similarity changes among the groups, bone resorption markers in the test HYP group were significantly decreased after 3 and 6 months in comparison to other groups (P < 0.05). After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups. Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.

No MeSH data available.


Related in: MedlinePlus