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Antiosteoporotic effect of orally administered yolk-derived peptides on bone mass in women.

Abdou AM, Watabe K, Yamane T, Isono T, Okamura Y, Kawahito S, Takeshima K, Masuda K, Kim M - Food Sci Nutr (2014)

Bottom Line: The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years.After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups.Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.

View Article: PubMed Central - PubMed

Affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.

ABSTRACT
The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years. Subjects were divided into three groups, and then enrolled in a 6-month, randomized, double-blind clinical trial. Bone formation and resorption markers were measured at 0, 3, and 6 months, while bone mineral density (BMD) in the lumbar spines was measured at 0 and 6 months. Although the bone formation marker levels showed the similarity changes among the groups, bone resorption markers in the test HYP group were significantly decreased after 3 and 6 months in comparison to other groups (P < 0.05). After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups. Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.

No MeSH data available.


Related in: MedlinePlus

Analysis of molecular weight distributions of yolk-derived peptide preparation.
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fig01: Analysis of molecular weight distributions of yolk-derived peptide preparation.

Mentions: The molecular weight distribution analysis of HYP is shown in Figure 1. Chromatography showed that about 85% of the HYP had a molecular weight of less than 3000 Da and about 70% less than 1000 Da. This relatively low molecular weight of HYP would enhance the absorption and bioavailability of the functional peptides in human (Feng et al. 2009). Effect of different pH, temperatures, and different digestive enzymes against HYP in vitro has been examined and showed its stability for heat up to 140°C, pH 2.0–9.0, and stability to enzymatic digestion (data not shown), therefore, the oral intake of HYP would not undergo further degradation in subjects in this study.


Antiosteoporotic effect of orally administered yolk-derived peptides on bone mass in women.

Abdou AM, Watabe K, Yamane T, Isono T, Okamura Y, Kawahito S, Takeshima K, Masuda K, Kim M - Food Sci Nutr (2014)

Analysis of molecular weight distributions of yolk-derived peptide preparation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048604&req=5

fig01: Analysis of molecular weight distributions of yolk-derived peptide preparation.
Mentions: The molecular weight distribution analysis of HYP is shown in Figure 1. Chromatography showed that about 85% of the HYP had a molecular weight of less than 3000 Da and about 70% less than 1000 Da. This relatively low molecular weight of HYP would enhance the absorption and bioavailability of the functional peptides in human (Feng et al. 2009). Effect of different pH, temperatures, and different digestive enzymes against HYP in vitro has been examined and showed its stability for heat up to 140°C, pH 2.0–9.0, and stability to enzymatic digestion (data not shown), therefore, the oral intake of HYP would not undergo further degradation in subjects in this study.

Bottom Line: The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years.After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups.Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.

View Article: PubMed Central - PubMed

Affiliation: Pharma Foods International Co., Ltd. Kyoto, 615-8245, Japan.

ABSTRACT
The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years. Subjects were divided into three groups, and then enrolled in a 6-month, randomized, double-blind clinical trial. Bone formation and resorption markers were measured at 0, 3, and 6 months, while bone mineral density (BMD) in the lumbar spines was measured at 0 and 6 months. Although the bone formation marker levels showed the similarity changes among the groups, bone resorption markers in the test HYP group were significantly decreased after 3 and 6 months in comparison to other groups (P < 0.05). After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups. Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.

No MeSH data available.


Related in: MedlinePlus