Limits...
Plasma levels of the pro-inflammatory protein S100A12 (EN-RAGE) are associated with muscle and fat mass in hemodialysis patients: a cross-sectional study.

Fukasawa H, Ishigaki S, Kinoshita-Katahashi N, Yasuda H, Kumagai H, Furuya R - Nutr J (2014)

Bottom Line: In contrast, sRAGE was not shown to significantly correlate with either of these factors.Multiple regression analyses demonstrated that S100A12 is a significant independent predictor of both muscle mass and fat mass (P < 0.01 and P < 0.05, respectively).Study number; UMIN000012341.

View Article: PubMed Central - HTML - PubMed

Affiliation: Renal Division, Department of Internal Medicine, Iwata City Hospital, 512-3 Ohkubo, Iwata, Shizuoka, Japan. hfukasawaucsd@gmail.com.

ABSTRACT

Background: Malnutrition is highly prevalent and contributes to mortality in hemodialysis (HD) patients. Although the receptor for advanced glycation end products (RAGE) system also contributes to the morbidity and mortality of these patients, the role that the RAGE system plays in determining nutritional status is currently unknown.

Methods: A cross-sectional study examining 79 HD patients was performed. The plasma concentrations of the soluble RAGE (sRAGE) and S100A12 (also known as EN-RAGE) were studied to evaluate their association with nutritional status, which was assessed by measuring the mid-thigh muscle mass and subcutaneous fat mass with computed tomography.

Results: Plasma S100A12 concentrations were shown to be significantly and negatively correlated with muscle mass and with fat mass (r = -0.237, P < 0.05 and r = -0.261, P < 0.05, respectively). In contrast, sRAGE was not shown to significantly correlate with either of these factors. Multiple regression analyses demonstrated that S100A12 is a significant independent predictor of both muscle mass and fat mass (P < 0.01 and P < 0.05, respectively).

Conclusions: Our findings suggest that plasma S100A12 levels could play an important role in determining muscle mass and fat mass in HD patients.

Trial registration: Study number; UMIN000012341.

Show MeSH

Related in: MedlinePlus

Associations between (A) TMA standardized for DW and plasma S100A12 levels and (B) TSFA standardized for DW and plasma S100A12 levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4048598&req=5

Figure 1: Associations between (A) TMA standardized for DW and plasma S100A12 levels and (B) TSFA standardized for DW and plasma S100A12 levels.

Mentions: Significant positive correlations were observed between TMA/DW and the serum levels of albumin (P < 0.001) and creatinine (P < 0.001). In addition, TMA/DW was negatively correlated with age (P < 0.05) and Kt/Vurea (P < 0.05) (Table 2). TMA/DW was also negatively associated with CRP (P < 0.05) levels and with log-transformed S100A12 (P < 0.05, Figure 1A). Significant positive correlations were observed between TSFA/DW and the BMI (P < 0.05), total cholesterol (P < 0.01), LDL cholesterol (P < 0.05), serum creatinine (P < 0.001) and Kt/Vurea (P < 0.05) levels. However, TSFA/DW was negatively correlated with the CRP (P < 0.01) and log-transformed S100A12 (P < 0.05, Figure 1B) levels. Following log transformation, the sRAGE levels were shown to be negatively associated with BMI, but no significant associations were observed with TMA/DW and TSFA/DW, or the log-transformed S100A12 level. However, significant negative correlations were observed between the log-transformed S100A12 levels and HD vintage (P < 0.05), serum albumin (P < 0.01), TMA/DW (P < 0.05, Figure 1A), and TSFA/DW (P < 0.05, Figure 1B). In contrast, positive correlations were observed between log-transformed S100A12 levels and the levels of β2-microglobulin (P < 0.05) and CRP (P < 0.001).


Plasma levels of the pro-inflammatory protein S100A12 (EN-RAGE) are associated with muscle and fat mass in hemodialysis patients: a cross-sectional study.

Fukasawa H, Ishigaki S, Kinoshita-Katahashi N, Yasuda H, Kumagai H, Furuya R - Nutr J (2014)

Associations between (A) TMA standardized for DW and plasma S100A12 levels and (B) TSFA standardized for DW and plasma S100A12 levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4048598&req=5

Figure 1: Associations between (A) TMA standardized for DW and plasma S100A12 levels and (B) TSFA standardized for DW and plasma S100A12 levels.
Mentions: Significant positive correlations were observed between TMA/DW and the serum levels of albumin (P < 0.001) and creatinine (P < 0.001). In addition, TMA/DW was negatively correlated with age (P < 0.05) and Kt/Vurea (P < 0.05) (Table 2). TMA/DW was also negatively associated with CRP (P < 0.05) levels and with log-transformed S100A12 (P < 0.05, Figure 1A). Significant positive correlations were observed between TSFA/DW and the BMI (P < 0.05), total cholesterol (P < 0.01), LDL cholesterol (P < 0.05), serum creatinine (P < 0.001) and Kt/Vurea (P < 0.05) levels. However, TSFA/DW was negatively correlated with the CRP (P < 0.01) and log-transformed S100A12 (P < 0.05, Figure 1B) levels. Following log transformation, the sRAGE levels were shown to be negatively associated with BMI, but no significant associations were observed with TMA/DW and TSFA/DW, or the log-transformed S100A12 level. However, significant negative correlations were observed between the log-transformed S100A12 levels and HD vintage (P < 0.05), serum albumin (P < 0.01), TMA/DW (P < 0.05, Figure 1A), and TSFA/DW (P < 0.05, Figure 1B). In contrast, positive correlations were observed between log-transformed S100A12 levels and the levels of β2-microglobulin (P < 0.05) and CRP (P < 0.001).

Bottom Line: In contrast, sRAGE was not shown to significantly correlate with either of these factors.Multiple regression analyses demonstrated that S100A12 is a significant independent predictor of both muscle mass and fat mass (P < 0.01 and P < 0.05, respectively).Study number; UMIN000012341.

View Article: PubMed Central - HTML - PubMed

Affiliation: Renal Division, Department of Internal Medicine, Iwata City Hospital, 512-3 Ohkubo, Iwata, Shizuoka, Japan. hfukasawaucsd@gmail.com.

ABSTRACT

Background: Malnutrition is highly prevalent and contributes to mortality in hemodialysis (HD) patients. Although the receptor for advanced glycation end products (RAGE) system also contributes to the morbidity and mortality of these patients, the role that the RAGE system plays in determining nutritional status is currently unknown.

Methods: A cross-sectional study examining 79 HD patients was performed. The plasma concentrations of the soluble RAGE (sRAGE) and S100A12 (also known as EN-RAGE) were studied to evaluate their association with nutritional status, which was assessed by measuring the mid-thigh muscle mass and subcutaneous fat mass with computed tomography.

Results: Plasma S100A12 concentrations were shown to be significantly and negatively correlated with muscle mass and with fat mass (r = -0.237, P < 0.05 and r = -0.261, P < 0.05, respectively). In contrast, sRAGE was not shown to significantly correlate with either of these factors. Multiple regression analyses demonstrated that S100A12 is a significant independent predictor of both muscle mass and fat mass (P < 0.01 and P < 0.05, respectively).

Conclusions: Our findings suggest that plasma S100A12 levels could play an important role in determining muscle mass and fat mass in HD patients.

Trial registration: Study number; UMIN000012341.

Show MeSH
Related in: MedlinePlus