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Higher blood glucose level associated with body mass index and gut microbiota in elderly people.

Sepp E, Kolk H, Lõivukene K, Mikelsaar M - Microb. Ecol. Health Dis. (2014)

Bottom Line: In elderly people, a higher blood glucose concentration was predicted by the reduction of the anaerobes' proportion (adj. sex, age, and BMI R(2)=0.192, p=0.028) and that of Bacteroides sp. (adj.R(2)=0.309, p=0.016).A tight interplay between increased BMI, level of blood glucose, and the reduced proportion of cultivable bacteroides is taking place in the gut microbiota of elderly people.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, Medical Faculty, University of Tartu, Tartu, Estonia.

ABSTRACT

Background: Some dominant bacterial divisions of the intestines have been linked to metabolic diseases such as overweight and diabetes.

Objective: A pilot study aimed to evaluate the relations between the culturable intestinal bacteria with body mass index (BMI) and some principal cellular and metabolic markers of blood in people older than 65.

Design: Altogether 38 generally healthy elderly people were recruited: ambulatory (n=19) and orthopedic surgery (n=19). Questionnaires on general health, anthropometric measurements, routine clinical and laboratory data, and quantitative composition of cultivable gut microbiota were performed.

Results: Blood glucose level was positively correlated with BMI (r=0.402; p=0.014). Higher blood glucose level had negative correlation with relative share of intestinal anaerobic bacteria such as bacteroides (r=-0.434; p=0.0076) and gram-positive anaerobic cocci (r=-0.364; p=0.027). In contrast, the relative share of bifidobacteria (r=0.383; p=0.019) and staphylococci (r=0.433; p=0.008) was positively correlated to blood glucose level. In elderly people, a higher blood glucose concentration was predicted by the reduction of the anaerobes' proportion (adj. sex, age, and BMI R(2)=0.192, p=0.028) and that of Bacteroides sp. (adj. R(2)=0.309, p=0.016).

Conclusion: A tight interplay between increased BMI, level of blood glucose, and the reduced proportion of cultivable bacteroides is taking place in the gut microbiota of elderly people.

No MeSH data available.


Related in: MedlinePlus

The correlation of BMI and blood glucose level.
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Figure 0001: The correlation of BMI and blood glucose level.

Mentions: In linked groups of elderly (n=38), blood glucose level was positively correlated with BMI (r=0.402; p=0.014; Fig. 1). The diversity of gut microbiota was in positive correlation with anaerobic bacteria as gram-positive cocci (r=0.449; p=0.005) and clostridia (r=0.489; p=0.002). At the same time, blood glucose level had negative correlation with total relative share of anaerobic bacteria in gut (r=−0.329; p=0.047). The enhanced blood glucose level had negative correlation with relative share of intestinal anaerobic bacteria-like bacteroides (r=−0.434; p=0.0076) and with counts and relative share of gram-positive anaerobic cocci (r=−0.365; p=0.024; and r=−0.364; p=0.027). In contrast, the counts and relative share of bifidobacteria (r=0.325; p=0.046 and r=0.383; p=0.019) and staphylococci (r=0.382; p=0.018 and r=0.433; p=0.008) had positive correlation with blood glucose level.


Higher blood glucose level associated with body mass index and gut microbiota in elderly people.

Sepp E, Kolk H, Lõivukene K, Mikelsaar M - Microb. Ecol. Health Dis. (2014)

The correlation of BMI and blood glucose level.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048595&req=5

Figure 0001: The correlation of BMI and blood glucose level.
Mentions: In linked groups of elderly (n=38), blood glucose level was positively correlated with BMI (r=0.402; p=0.014; Fig. 1). The diversity of gut microbiota was in positive correlation with anaerobic bacteria as gram-positive cocci (r=0.449; p=0.005) and clostridia (r=0.489; p=0.002). At the same time, blood glucose level had negative correlation with total relative share of anaerobic bacteria in gut (r=−0.329; p=0.047). The enhanced blood glucose level had negative correlation with relative share of intestinal anaerobic bacteria-like bacteroides (r=−0.434; p=0.0076) and with counts and relative share of gram-positive anaerobic cocci (r=−0.365; p=0.024; and r=−0.364; p=0.027). In contrast, the counts and relative share of bifidobacteria (r=0.325; p=0.046 and r=0.383; p=0.019) and staphylococci (r=0.382; p=0.018 and r=0.433; p=0.008) had positive correlation with blood glucose level.

Bottom Line: In elderly people, a higher blood glucose concentration was predicted by the reduction of the anaerobes' proportion (adj. sex, age, and BMI R(2)=0.192, p=0.028) and that of Bacteroides sp. (adj.R(2)=0.309, p=0.016).A tight interplay between increased BMI, level of blood glucose, and the reduced proportion of cultivable bacteroides is taking place in the gut microbiota of elderly people.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, Medical Faculty, University of Tartu, Tartu, Estonia.

ABSTRACT

Background: Some dominant bacterial divisions of the intestines have been linked to metabolic diseases such as overweight and diabetes.

Objective: A pilot study aimed to evaluate the relations between the culturable intestinal bacteria with body mass index (BMI) and some principal cellular and metabolic markers of blood in people older than 65.

Design: Altogether 38 generally healthy elderly people were recruited: ambulatory (n=19) and orthopedic surgery (n=19). Questionnaires on general health, anthropometric measurements, routine clinical and laboratory data, and quantitative composition of cultivable gut microbiota were performed.

Results: Blood glucose level was positively correlated with BMI (r=0.402; p=0.014). Higher blood glucose level had negative correlation with relative share of intestinal anaerobic bacteria such as bacteroides (r=-0.434; p=0.0076) and gram-positive anaerobic cocci (r=-0.364; p=0.027). In contrast, the relative share of bifidobacteria (r=0.383; p=0.019) and staphylococci (r=0.433; p=0.008) was positively correlated to blood glucose level. In elderly people, a higher blood glucose concentration was predicted by the reduction of the anaerobes' proportion (adj. sex, age, and BMI R(2)=0.192, p=0.028) and that of Bacteroides sp. (adj. R(2)=0.309, p=0.016).

Conclusion: A tight interplay between increased BMI, level of blood glucose, and the reduced proportion of cultivable bacteroides is taking place in the gut microbiota of elderly people.

No MeSH data available.


Related in: MedlinePlus