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Effect of exercise-induced enhancement of the leg-extensor muscle-tendon unit capacities on ambulatory mechanics and knee osteoarthritis markers in the elderly.

Karamanidis K, Oberländer KD, Niehoff A, Epro G, Brüggemann GP - PLoS ONE (2014)

Bottom Line: Furthermore, post-intervention compared to pre-intervention, the elderly showed lower external hip adduction moment, but revealed higher plantarflexion pushoff moment.The changes in the external knee adduction moment were significantly correlated with the improvement in ankle pushoff function.This work emphasizes the important role played by the ankle pushoff function in knee joint mechanical loading during locomotion, and may justify the inclusion of the TS MTU in prevention programs aiming to positively influence specific mechanical markers for knee osteoarthritis in the elderly.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biomechanics and Orthopaedics, German Sport University of Cologne, Cologne, Germany; Department of Mathematics and Technology, University of Applied Sciences Koblenz, RheinAhrCampus Remagen, Koblenz, Germany.

ABSTRACT

Objective: Leg-extensor muscle weakness could be a key component in knee joint degeneration in the elderly because it may result in altered muscular control during locomotion influencing the mechanical environment within the joint. This work aimed to examine whether an exercise-induced enhancement of the triceps surae (TS) and quadriceps femoris (QF) muscle-tendon unit (MTU) capacities would affect mechanical and biological markers for knee osteoarthritis in the elderly.

Methods: Twelve older women completed a 14-week TS and QF MTU exercise intervention, which had already been established as increasing muscle strength and tendon stiffness. Locomotion mechanics and serum cartilage oligomeric matrix protein (COMP) levels were examined during incline walking. MTU mechanical properties were assessed using simultaneously ultrasonography and dynamometry.

Results: Post exercise intervention, the elderly had higher TS and QF contractile strength and tendon-aponeurosis stiffness. Regarding the incline gait task, the subjects demonstrated a lower external knee adduction moment and lower knee adduction angular impulse during the stance phase post-intervention. Furthermore, post-intervention compared to pre-intervention, the elderly showed lower external hip adduction moment, but revealed higher plantarflexion pushoff moment. The changes in the external knee adduction moment were significantly correlated with the improvement in ankle pushoff function. Serum COMP concentration increased in response to the 0.5-h incline walking exercise with no differences in the magnitude of increment between pre- and post-intervention.

Conclusions: This work emphasizes the important role played by the ankle pushoff function in knee joint mechanical loading during locomotion, and may justify the inclusion of the TS MTU in prevention programs aiming to positively influence specific mechanical markers for knee osteoarthritis in the elderly. However, the study was unable to show that COMP is amenable to change in the elderly following a 14-week exercise intervention and, therefore, the physiological benefit of improved muscle function for knee cartilage requires further investigation.

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Serum Cartilage Oligomeric Matrix Protein (COMP) concentration before (−0.5-h; baseline), immediately after (0-h), and 0.5- and 1.0-h after the 0.5-h incline walking exercise determined before (pre) and after (post) the triceps surae and quadriceps femoris muscle-tendon unit exercise-intervention.Please note that serum COMP concentrations are presented as percent of baseline serum concentration and all statistical tests were performed on absolute values. There was no significant muscle-tendon unit exercise-intervention effect on serum COMP concentration (P = 0.23). 1: Statistically significant differences to −0.5-h (P<0.05). 2: Statistically significant differences to 0-h (P<0.05). 3. Statistically significant differences to 0.5-h (P<0.05).
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pone-0099330-g006: Serum Cartilage Oligomeric Matrix Protein (COMP) concentration before (−0.5-h; baseline), immediately after (0-h), and 0.5- and 1.0-h after the 0.5-h incline walking exercise determined before (pre) and after (post) the triceps surae and quadriceps femoris muscle-tendon unit exercise-intervention.Please note that serum COMP concentrations are presented as percent of baseline serum concentration and all statistical tests were performed on absolute values. There was no significant muscle-tendon unit exercise-intervention effect on serum COMP concentration (P = 0.23). 1: Statistically significant differences to −0.5-h (P<0.05). 2: Statistically significant differences to 0-h (P<0.05). 3. Statistically significant differences to 0.5-h (P<0.05).

Mentions: Incline walking for 0.5-h had a significant (P<0.05) effect on serum COMP concentration (Fig. 6). The cyclic loading exercise leads to a significant (P<0.05) increase in serum COMP concentration with an average increase of 12.9% (pre MTU intervention) and 12.6% (post MTU intervention) with a pre/post effect size higher than 0.4. This increase of the serum COMP concentration immediately after walking exercise was not significantly (P>0.05) different between pre and post TS and QF MTU intervention (Fig. 6). Within a period of 1.0-h following the gait exercise, the COMP value decreased continuously and returned to a significantly (P<0.05) lower value compared to the baseline (Fig. 6). There was no significant (P>0.05) MTU exercise intervention effect and no intervention x time effect (P>0.05) on serum COMP concentration (Fig. 6).


Effect of exercise-induced enhancement of the leg-extensor muscle-tendon unit capacities on ambulatory mechanics and knee osteoarthritis markers in the elderly.

Karamanidis K, Oberländer KD, Niehoff A, Epro G, Brüggemann GP - PLoS ONE (2014)

Serum Cartilage Oligomeric Matrix Protein (COMP) concentration before (−0.5-h; baseline), immediately after (0-h), and 0.5- and 1.0-h after the 0.5-h incline walking exercise determined before (pre) and after (post) the triceps surae and quadriceps femoris muscle-tendon unit exercise-intervention.Please note that serum COMP concentrations are presented as percent of baseline serum concentration and all statistical tests were performed on absolute values. There was no significant muscle-tendon unit exercise-intervention effect on serum COMP concentration (P = 0.23). 1: Statistically significant differences to −0.5-h (P<0.05). 2: Statistically significant differences to 0-h (P<0.05). 3. Statistically significant differences to 0.5-h (P<0.05).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048280&req=5

pone-0099330-g006: Serum Cartilage Oligomeric Matrix Protein (COMP) concentration before (−0.5-h; baseline), immediately after (0-h), and 0.5- and 1.0-h after the 0.5-h incline walking exercise determined before (pre) and after (post) the triceps surae and quadriceps femoris muscle-tendon unit exercise-intervention.Please note that serum COMP concentrations are presented as percent of baseline serum concentration and all statistical tests were performed on absolute values. There was no significant muscle-tendon unit exercise-intervention effect on serum COMP concentration (P = 0.23). 1: Statistically significant differences to −0.5-h (P<0.05). 2: Statistically significant differences to 0-h (P<0.05). 3. Statistically significant differences to 0.5-h (P<0.05).
Mentions: Incline walking for 0.5-h had a significant (P<0.05) effect on serum COMP concentration (Fig. 6). The cyclic loading exercise leads to a significant (P<0.05) increase in serum COMP concentration with an average increase of 12.9% (pre MTU intervention) and 12.6% (post MTU intervention) with a pre/post effect size higher than 0.4. This increase of the serum COMP concentration immediately after walking exercise was not significantly (P>0.05) different between pre and post TS and QF MTU intervention (Fig. 6). Within a period of 1.0-h following the gait exercise, the COMP value decreased continuously and returned to a significantly (P<0.05) lower value compared to the baseline (Fig. 6). There was no significant (P>0.05) MTU exercise intervention effect and no intervention x time effect (P>0.05) on serum COMP concentration (Fig. 6).

Bottom Line: Furthermore, post-intervention compared to pre-intervention, the elderly showed lower external hip adduction moment, but revealed higher plantarflexion pushoff moment.The changes in the external knee adduction moment were significantly correlated with the improvement in ankle pushoff function.This work emphasizes the important role played by the ankle pushoff function in knee joint mechanical loading during locomotion, and may justify the inclusion of the TS MTU in prevention programs aiming to positively influence specific mechanical markers for knee osteoarthritis in the elderly.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biomechanics and Orthopaedics, German Sport University of Cologne, Cologne, Germany; Department of Mathematics and Technology, University of Applied Sciences Koblenz, RheinAhrCampus Remagen, Koblenz, Germany.

ABSTRACT

Objective: Leg-extensor muscle weakness could be a key component in knee joint degeneration in the elderly because it may result in altered muscular control during locomotion influencing the mechanical environment within the joint. This work aimed to examine whether an exercise-induced enhancement of the triceps surae (TS) and quadriceps femoris (QF) muscle-tendon unit (MTU) capacities would affect mechanical and biological markers for knee osteoarthritis in the elderly.

Methods: Twelve older women completed a 14-week TS and QF MTU exercise intervention, which had already been established as increasing muscle strength and tendon stiffness. Locomotion mechanics and serum cartilage oligomeric matrix protein (COMP) levels were examined during incline walking. MTU mechanical properties were assessed using simultaneously ultrasonography and dynamometry.

Results: Post exercise intervention, the elderly had higher TS and QF contractile strength and tendon-aponeurosis stiffness. Regarding the incline gait task, the subjects demonstrated a lower external knee adduction moment and lower knee adduction angular impulse during the stance phase post-intervention. Furthermore, post-intervention compared to pre-intervention, the elderly showed lower external hip adduction moment, but revealed higher plantarflexion pushoff moment. The changes in the external knee adduction moment were significantly correlated with the improvement in ankle pushoff function. Serum COMP concentration increased in response to the 0.5-h incline walking exercise with no differences in the magnitude of increment between pre- and post-intervention.

Conclusions: This work emphasizes the important role played by the ankle pushoff function in knee joint mechanical loading during locomotion, and may justify the inclusion of the TS MTU in prevention programs aiming to positively influence specific mechanical markers for knee osteoarthritis in the elderly. However, the study was unable to show that COMP is amenable to change in the elderly following a 14-week exercise intervention and, therefore, the physiological benefit of improved muscle function for knee cartilage requires further investigation.

Show MeSH
Related in: MedlinePlus