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Inferior parietal lobule encodes visual temporal resolution processes contributing to the critical flicker frequency threshold in humans.

Nardella A, Rocchi L, Conte A, Bologna M, Suppa A, Berardelli A - PLoS ONE (2014)

Bottom Line: The measurement of the Critical Flicker Frequency threshold is used to study the visual temporal resolution in healthy subjects and in pathological conditions.The Critical Flicker Frequency threshold was measured in twelve healthy subjects before and after cTBS applied over different cortical areas in separate sessions. cTBS over the left inferior parietal lobule altered the Critical Flicker Frequency threshold, whereas cTBS over the left mediotemporal cortex, primary visual cortex and right inferior parietal lobule left the Critical Flicker Frequency threshold unchanged.No statistical difference was found when the red or blue lights were used.

View Article: PubMed Central - PubMed

Affiliation: IRCCS Neuromed, Pozzilli, Isernia, Italy.

ABSTRACT
The measurement of the Critical Flicker Frequency threshold is used to study the visual temporal resolution in healthy subjects and in pathological conditions. To better understand the role played by different cortical areas in the Critical Flicker Frequency threshold perception we used continuous Theta Burst Stimulation (cTBS), an inhibitory plasticity-inducing protocol based on repetitive transcranial magnetic stimulation. The Critical Flicker Frequency threshold was measured in twelve healthy subjects before and after cTBS applied over different cortical areas in separate sessions. cTBS over the left inferior parietal lobule altered the Critical Flicker Frequency threshold, whereas cTBS over the left mediotemporal cortex, primary visual cortex and right inferior parietal lobule left the Critical Flicker Frequency threshold unchanged. No statistical difference was found when the red or blue lights were used. Our findings show that left inferior parietal lobule is causally involved in the conscious perception of Critical Flicker Frequency and that Critical Flicker Frequency threshold can be modulated by plasticity-inducing protocols.

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Related in: MedlinePlus

Changes in blue-LED critical flicker frequency threshold induced by cTBS over left inferior parietal lobule.Changes in blue LED-critical flicker frequency threshold (CFFt) measured with the ascending method and descending method on the right and left eye induced by cTBS over left inferior parietal lobule (IPL). Each column represents mean value; bars represent SE. Y axis represents CFFt values expressed in Hz. X axis represents time points (T0: before, T1: 5 minutes and T2: 30 minutes after cTBS).
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pone-0098948-g002: Changes in blue-LED critical flicker frequency threshold induced by cTBS over left inferior parietal lobule.Changes in blue LED-critical flicker frequency threshold (CFFt) measured with the ascending method and descending method on the right and left eye induced by cTBS over left inferior parietal lobule (IPL). Each column represents mean value; bars represent SE. Y axis represents CFFt values expressed in Hz. X axis represents time points (T0: before, T1: 5 minutes and T2: 30 minutes after cTBS).

Mentions: Repeated measures ANOVA showed a significant interaction of factors "cortical areas" and “time” for the ascending method-red light (F(6,66) = 4.92; p<0.01), descending method-red light (F(6,66) = 2.24; p = 0.04), ascending method-blue light (F(6,66) = 2.29; p = 0.04) and descending method-blue light (F(3.01,33.1) = 3.07; p = 0.04). Post-hoc analysis showed that cTBS over left IPL significantly reduced the CFFt (Figures 1 and 2), whereas it did not when delivered over V1, left hMT/V5+ and right IPL (Figure 3 and 4). Left IPL cTBS-induced decrease in CFFt was significant at T1 and to a lesser extent at T2 for all the red and blue thresholds in both the right and left eyes (ascending method-red light right eye: T1: p<0.0005, T2: p = 0.04; ascending method-red light left eye: T1: p<0.0001, T2: p = 0.02; descending method-red light right eye: T1: p = 0.0003, T2: p = 0.02; descending method-red light left eye: T1: p = 0.001, T2: p = 0.01; ascending method-blue light right eye: T1: p = 0.01; T2: p = 0.03, ascending method-blue light left eye: T1: p = 0.002; T2: p = 0.03; descending method-blue light right eye: T1: p = 0.0001, T2: p = 0.02; descending method-blue light left eye: T1: p = 0.002, T2: p = 0.02). Repeated measures ANOVA performed to compare CFFt values at T0 in each experimental session showed that the CFFt values at T0 did not differ significantly across the experimental sessions of the ascending method-red light (F(3,33) = 2.39; p = 0.09), descending method-red light (F(3,33) = 0.48; p = 0.69), ascending method-blue light (F(3,33) = 0.07; p = 0.97) or descending method-blue light (F(3,33) = 0.92; p = 0.44) (Table 1).


Inferior parietal lobule encodes visual temporal resolution processes contributing to the critical flicker frequency threshold in humans.

Nardella A, Rocchi L, Conte A, Bologna M, Suppa A, Berardelli A - PLoS ONE (2014)

Changes in blue-LED critical flicker frequency threshold induced by cTBS over left inferior parietal lobule.Changes in blue LED-critical flicker frequency threshold (CFFt) measured with the ascending method and descending method on the right and left eye induced by cTBS over left inferior parietal lobule (IPL). Each column represents mean value; bars represent SE. Y axis represents CFFt values expressed in Hz. X axis represents time points (T0: before, T1: 5 minutes and T2: 30 minutes after cTBS).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4048231&req=5

pone-0098948-g002: Changes in blue-LED critical flicker frequency threshold induced by cTBS over left inferior parietal lobule.Changes in blue LED-critical flicker frequency threshold (CFFt) measured with the ascending method and descending method on the right and left eye induced by cTBS over left inferior parietal lobule (IPL). Each column represents mean value; bars represent SE. Y axis represents CFFt values expressed in Hz. X axis represents time points (T0: before, T1: 5 minutes and T2: 30 minutes after cTBS).
Mentions: Repeated measures ANOVA showed a significant interaction of factors "cortical areas" and “time” for the ascending method-red light (F(6,66) = 4.92; p<0.01), descending method-red light (F(6,66) = 2.24; p = 0.04), ascending method-blue light (F(6,66) = 2.29; p = 0.04) and descending method-blue light (F(3.01,33.1) = 3.07; p = 0.04). Post-hoc analysis showed that cTBS over left IPL significantly reduced the CFFt (Figures 1 and 2), whereas it did not when delivered over V1, left hMT/V5+ and right IPL (Figure 3 and 4). Left IPL cTBS-induced decrease in CFFt was significant at T1 and to a lesser extent at T2 for all the red and blue thresholds in both the right and left eyes (ascending method-red light right eye: T1: p<0.0005, T2: p = 0.04; ascending method-red light left eye: T1: p<0.0001, T2: p = 0.02; descending method-red light right eye: T1: p = 0.0003, T2: p = 0.02; descending method-red light left eye: T1: p = 0.001, T2: p = 0.01; ascending method-blue light right eye: T1: p = 0.01; T2: p = 0.03, ascending method-blue light left eye: T1: p = 0.002; T2: p = 0.03; descending method-blue light right eye: T1: p = 0.0001, T2: p = 0.02; descending method-blue light left eye: T1: p = 0.002, T2: p = 0.02). Repeated measures ANOVA performed to compare CFFt values at T0 in each experimental session showed that the CFFt values at T0 did not differ significantly across the experimental sessions of the ascending method-red light (F(3,33) = 2.39; p = 0.09), descending method-red light (F(3,33) = 0.48; p = 0.69), ascending method-blue light (F(3,33) = 0.07; p = 0.97) or descending method-blue light (F(3,33) = 0.92; p = 0.44) (Table 1).

Bottom Line: The measurement of the Critical Flicker Frequency threshold is used to study the visual temporal resolution in healthy subjects and in pathological conditions.The Critical Flicker Frequency threshold was measured in twelve healthy subjects before and after cTBS applied over different cortical areas in separate sessions. cTBS over the left inferior parietal lobule altered the Critical Flicker Frequency threshold, whereas cTBS over the left mediotemporal cortex, primary visual cortex and right inferior parietal lobule left the Critical Flicker Frequency threshold unchanged.No statistical difference was found when the red or blue lights were used.

View Article: PubMed Central - PubMed

Affiliation: IRCCS Neuromed, Pozzilli, Isernia, Italy.

ABSTRACT
The measurement of the Critical Flicker Frequency threshold is used to study the visual temporal resolution in healthy subjects and in pathological conditions. To better understand the role played by different cortical areas in the Critical Flicker Frequency threshold perception we used continuous Theta Burst Stimulation (cTBS), an inhibitory plasticity-inducing protocol based on repetitive transcranial magnetic stimulation. The Critical Flicker Frequency threshold was measured in twelve healthy subjects before and after cTBS applied over different cortical areas in separate sessions. cTBS over the left inferior parietal lobule altered the Critical Flicker Frequency threshold, whereas cTBS over the left mediotemporal cortex, primary visual cortex and right inferior parietal lobule left the Critical Flicker Frequency threshold unchanged. No statistical difference was found when the red or blue lights were used. Our findings show that left inferior parietal lobule is causally involved in the conscious perception of Critical Flicker Frequency and that Critical Flicker Frequency threshold can be modulated by plasticity-inducing protocols.

Show MeSH
Related in: MedlinePlus