Limits...
An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.

Mannelqvist M, Wik E, Stefansson IM, Akslen LA - PLoS ONE (2014)

Bottom Line: Vascular invasion by tumor cells is known to be important for cancer progression.Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Norway.

ABSTRACT

Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients.

Methods and results: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.

Conclusions: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

Show MeSH

Related in: MedlinePlus

Correlation between the Vascular Invasion Signature and tumor progression signatures.Vascular Invasion Signature score shows a correlation to the VEGF signature, wound response signature, NF-Kβ related genes, hypoxia gene signature, BMI-1 signature and Oncotype DX Recurrence Score in breast cancer data sets; (A) GSE1456 and (B) GSE20685. The Spearman rank correlation test was used for bivariate correlations.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4048217&req=5

pone-0098787-g004: Correlation between the Vascular Invasion Signature and tumor progression signatures.Vascular Invasion Signature score shows a correlation to the VEGF signature, wound response signature, NF-Kβ related genes, hypoxia gene signature, BMI-1 signature and Oncotype DX Recurrence Score in breast cancer data sets; (A) GSE1456 and (B) GSE20685. The Spearman rank correlation test was used for bivariate correlations.

Mentions: Six gene signatures related to tumor progression were mapped in the two breast cancer data sets with survival information for cancer specific death and overall survival (GSE1456 and GSE20685), and the correlations between the signature scores were explored. In data set GSE1456 (Figure 4A), all signatures were significantly correlated to the vascular invasion score, with Rs from 0.29–0.54. In data set GSE20685 (Figure 4B), all signatures except the hypoxia score show significant correlation to the vascular invasion score, with Rs from 0.36–0.50.


An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.

Mannelqvist M, Wik E, Stefansson IM, Akslen LA - PLoS ONE (2014)

Correlation between the Vascular Invasion Signature and tumor progression signatures.Vascular Invasion Signature score shows a correlation to the VEGF signature, wound response signature, NF-Kβ related genes, hypoxia gene signature, BMI-1 signature and Oncotype DX Recurrence Score in breast cancer data sets; (A) GSE1456 and (B) GSE20685. The Spearman rank correlation test was used for bivariate correlations.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048217&req=5

pone-0098787-g004: Correlation between the Vascular Invasion Signature and tumor progression signatures.Vascular Invasion Signature score shows a correlation to the VEGF signature, wound response signature, NF-Kβ related genes, hypoxia gene signature, BMI-1 signature and Oncotype DX Recurrence Score in breast cancer data sets; (A) GSE1456 and (B) GSE20685. The Spearman rank correlation test was used for bivariate correlations.
Mentions: Six gene signatures related to tumor progression were mapped in the two breast cancer data sets with survival information for cancer specific death and overall survival (GSE1456 and GSE20685), and the correlations between the signature scores were explored. In data set GSE1456 (Figure 4A), all signatures were significantly correlated to the vascular invasion score, with Rs from 0.29–0.54. In data set GSE20685 (Figure 4B), all signatures except the hypoxia score show significant correlation to the vascular invasion score, with Rs from 0.36–0.50.

Bottom Line: Vascular invasion by tumor cells is known to be important for cancer progression.Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Norway.

ABSTRACT

Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients.

Methods and results: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.

Conclusions: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

Show MeSH
Related in: MedlinePlus