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An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.

Mannelqvist M, Wik E, Stefansson IM, Akslen LA - PLoS ONE (2014)

Bottom Line: Vascular invasion by tumor cells is known to be important for cancer progression.Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Norway.

ABSTRACT

Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients.

Methods and results: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.

Conclusions: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

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Related in: MedlinePlus

High Vascular Invasion Signature score is associated with reduced survival.High signature score is associated with reduced survival in datasets GSE1456 and GSE20685. Univariate survival analysis was performed by the Kaplan-Meier method (log-rank significance test). For each category, the number of cases is given followed by the number of breast cancer deaths.
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pone-0098787-g002: High Vascular Invasion Signature score is associated with reduced survival.High signature score is associated with reduced survival in datasets GSE1456 and GSE20685. Univariate survival analysis was performed by the Kaplan-Meier method (log-rank significance test). For each category, the number of cases is given followed by the number of breast cancer deaths.

Mentions: Data set GSE1456 had information on breast cancer specific deaths and data set GSE20685 had information on overall survival [7], [12]. A high signature score was significantly associated with reduced survival in both these data sets (Kaplan-Meier method, log-rank test, p<0.001 and p = 0.002; Figure 2). Also, four data sets had information on recurrence free survival [7], [11], [12], [16]. A high signature score was associated with reduced recurrence free survival in three data sets, whereas the fourth data set showed a trend between reduced recurrence free survival and high signature score (p = 0.079) (Figure 3).


An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.

Mannelqvist M, Wik E, Stefansson IM, Akslen LA - PLoS ONE (2014)

High Vascular Invasion Signature score is associated with reduced survival.High signature score is associated with reduced survival in datasets GSE1456 and GSE20685. Univariate survival analysis was performed by the Kaplan-Meier method (log-rank significance test). For each category, the number of cases is given followed by the number of breast cancer deaths.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048217&req=5

pone-0098787-g002: High Vascular Invasion Signature score is associated with reduced survival.High signature score is associated with reduced survival in datasets GSE1456 and GSE20685. Univariate survival analysis was performed by the Kaplan-Meier method (log-rank significance test). For each category, the number of cases is given followed by the number of breast cancer deaths.
Mentions: Data set GSE1456 had information on breast cancer specific deaths and data set GSE20685 had information on overall survival [7], [12]. A high signature score was significantly associated with reduced survival in both these data sets (Kaplan-Meier method, log-rank test, p<0.001 and p = 0.002; Figure 2). Also, four data sets had information on recurrence free survival [7], [11], [12], [16]. A high signature score was associated with reduced recurrence free survival in three data sets, whereas the fourth data set showed a trend between reduced recurrence free survival and high signature score (p = 0.079) (Figure 3).

Bottom Line: Vascular invasion by tumor cells is known to be important for cancer progression.Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Norway.

ABSTRACT

Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients.

Methods and results: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.

Conclusions: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

Show MeSH
Related in: MedlinePlus