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An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.

Mannelqvist M, Wik E, Stefansson IM, Akslen LA - PLoS ONE (2014)

Bottom Line: Vascular invasion by tumor cells is known to be important for cancer progression.Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Norway.

ABSTRACT

Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients.

Methods and results: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.

Conclusions: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

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Related in: MedlinePlus

High Vascular Invasion Signature score is associated with Basal-like and HER2 molecular subtypes.High signature score is associated with Basal-like and HER2 molecular subtypes among data sets GSE25066, GSE22358, GSE1456 and GSE20685. Correlations were assessed by Kruskal-Wallis test. Mean expression signature scores indicated by circles, and the bars represent standard error ±2.
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pone-0098787-g001: High Vascular Invasion Signature score is associated with Basal-like and HER2 molecular subtypes.High signature score is associated with Basal-like and HER2 molecular subtypes among data sets GSE25066, GSE22358, GSE1456 and GSE20685. Correlations were assessed by Kruskal-Wallis test. Mean expression signature scores indicated by circles, and the bars represent standard error ±2.

Mentions: Three of the data sets had information on molecular subtypes of breast cancer such as Luminal A, Luminal B, HER2, basal-like, and Normal breast-like [7], [14], [15]. All data sets showed highly significant correlations between the subtypes and the vascular invasion signature score, p<0.001 (Table 4). The most aggressive basal-like and HER2 subtypes showed the highest signature score and Luminal A, Luminal B and normal breast-like the lowest. A fourth data set had molecular subtypes classified from I–VI [12]. When compared with the Sørlie classification [6], the results are similar to the three data sets mentioned above (Table 4 and Figure 1).


An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.

Mannelqvist M, Wik E, Stefansson IM, Akslen LA - PLoS ONE (2014)

High Vascular Invasion Signature score is associated with Basal-like and HER2 molecular subtypes.High signature score is associated with Basal-like and HER2 molecular subtypes among data sets GSE25066, GSE22358, GSE1456 and GSE20685. Correlations were assessed by Kruskal-Wallis test. Mean expression signature scores indicated by circles, and the bars represent standard error ±2.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4048217&req=5

pone-0098787-g001: High Vascular Invasion Signature score is associated with Basal-like and HER2 molecular subtypes.High signature score is associated with Basal-like and HER2 molecular subtypes among data sets GSE25066, GSE22358, GSE1456 and GSE20685. Correlations were assessed by Kruskal-Wallis test. Mean expression signature scores indicated by circles, and the bars represent standard error ±2.
Mentions: Three of the data sets had information on molecular subtypes of breast cancer such as Luminal A, Luminal B, HER2, basal-like, and Normal breast-like [7], [14], [15]. All data sets showed highly significant correlations between the subtypes and the vascular invasion signature score, p<0.001 (Table 4). The most aggressive basal-like and HER2 subtypes showed the highest signature score and Luminal A, Luminal B and normal breast-like the lowest. A fourth data set had molecular subtypes classified from I–VI [12]. When compared with the Sørlie classification [6], the results are similar to the three data sets mentioned above (Table 4 and Figure 1).

Bottom Line: Vascular invasion by tumor cells is known to be important for cancer progression.Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Norway.

ABSTRACT

Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. Here, we explored the significance of this vascular invasion signature in multiple series of breast cancer patients.

Methods and results: The study includes 11 open access gene expression data sets which collectively provide information on 2423 breast cancer patients. The 18-gene signature showed consistent associations with aggressive features of breast cancer, like high tumor grade, hormone receptor negativity, HER2 positivity, a basal-like phenotype, reduced patient survival, and response to neoadjuvant chemotherapy. Also, the vascular invasion signature was associated with several other gene expression profiles related to vascular biology and tumor progression, including the Oncotype DX breast cancer recurrence signature.

Conclusions: The 18-gene vascular invasion signature showed strong and consistent associations with aggressive features of breast cancer and reduced survival.

Show MeSH
Related in: MedlinePlus