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3D LGE imaging of the LV short axis stack using spiral readouts at 3T

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Clinical assessment of the viability of myocardium is commonly performed using 2D breath-hold late gadolinium enhancement (LGE) imaging with Cartesian k-space coverage and data acquisition windows (AWs) ranging from 140-200 ms... More efficient k-space coverage using spiral trajectories could allow improved spatial resolution and reduced AWs without greatly extending acquisition durations... To this end, we have developed a navigator-gated spiral 3D LGE sequence and present the results in 10 patients attending for clinical 2D LGE imaging on a 3T Siemens Skyra scanner... Acquisition duration was 34 cardiac cycles assuming 100% respiratory efficiency (alternate R-wave gating). 3D imaging was performed after the acquisition of a stack of conventional clinical breath-hold 2D LGE images in 10 patients (acquired resolution: 1.4 × 1.8 mm reconstructed to 0.7 × 0.7 mm)... The 2D images had slice thickness of 7 mm with slice gap of 3 mm... Acquisition duration was 14 cardiac cycles per slice (alternate R-wave gating)... LV blood SNR and blood-myocardium CNR in conventional 2D and spiral 3D scans were compared in 3 matched slices (basal, mid and apical) using paired Wilcoxon signed rank test... SNR measurements were significantly higher and CNR were borderline significantly higher for the 3D spiral compared to the 2D scans (SNR: 10.96 ± 2.71 vs 13.59 ± 4.70 (p < 0.01); CNR: 9.23 ± 2.60 vs 10.52 ± 4.00 (p = 0.06))... Figure 1 shows images from 2 example patients... Image quality over the LV is similar for 2D Cartesian and 3D spiral acquisitions although some off-resonance blurring can sometimes be seen in the spiral acquisitions, despite the short spiral readout durations (e.g. inferolateral wall of the RV in patient 1)... This may be improved using spatially varying off-resonance correction... Spiral 3D scans had mean acquisition duration 83 s (51-144 s), allowing for multiple repetitions or high resolution examination of regions of enhancement in similar duration as the 2D stack with 8 slices taking ~240 s; shorter AWs may also have reduced motion blurring... Navigator-gated 3D spiral LGE imaging allows contiguous coverage of the LV with higher spatial resolution, shorter acquisition windows and reduced acquisition durations when compared to a stack of conventional breath-hold 2D LGE Cartesian acquisitions.

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Images of the Basal slice from a third patient showing enhancement in the septum (arrowed). From left to right the images are from the 2D Cartesian, 3D spiral and a higher through plane resolution (HR - 16 × 1.5 mm slices) scans. The higher resolution scan shows better definition of the enhanced region in the mid wall.
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Figure 2: Images of the Basal slice from a third patient showing enhancement in the septum (arrowed). From left to right the images are from the 2D Cartesian, 3D spiral and a higher through plane resolution (HR - 16 × 1.5 mm slices) scans. The higher resolution scan shows better definition of the enhanced region in the mid wall.

Mentions: SNR measurements were significantly higher and CNR were borderline significantly higher for the 3D spiral compared to the 2D scans (SNR: 10.96 ± 2.71 vs 13.59 ± 4.70 (p < 0.01); CNR: 9.23 ± 2.60 vs 10.52 ± 4.00 (p = 0.06)). Figure 1 shows images from 2 example patients. Image quality over the LV is similar for 2D Cartesian and 3D spiral acquisitions although some off-resonance blurring can sometimes be seen in the spiral acquisitions, despite the short spiral readout durations (e.g. inferolateral wall of the RV in patient 1). This may be improved using spatially varying off-resonance correction. Figure 2 shows basal slices from a patient with enhancement in the septum which is more defined on the 3D spiral image due to better through-plane resolution and a reduced AW. A higher through-plane resolution 3D spiral image is also shown for comparison. Spiral 3D scans had mean acquisition duration 83 s (51-144 s), allowing for multiple repetitions or high resolution examination of regions of enhancement in similar duration as the 2D stack with 8 slices taking ~240 s; shorter AWs may also have reduced motion blurring.


3D LGE imaging of the LV short axis stack using spiral readouts at 3T
Images of the Basal slice from a third patient showing enhancement in the septum (arrowed). From left to right the images are from the 2D Cartesian, 3D spiral and a higher through plane resolution (HR - 16 × 1.5 mm slices) scans. The higher resolution scan shows better definition of the enhanced region in the mid wall.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4045738&req=5

Figure 2: Images of the Basal slice from a third patient showing enhancement in the septum (arrowed). From left to right the images are from the 2D Cartesian, 3D spiral and a higher through plane resolution (HR - 16 × 1.5 mm slices) scans. The higher resolution scan shows better definition of the enhanced region in the mid wall.
Mentions: SNR measurements were significantly higher and CNR were borderline significantly higher for the 3D spiral compared to the 2D scans (SNR: 10.96 ± 2.71 vs 13.59 ± 4.70 (p < 0.01); CNR: 9.23 ± 2.60 vs 10.52 ± 4.00 (p = 0.06)). Figure 1 shows images from 2 example patients. Image quality over the LV is similar for 2D Cartesian and 3D spiral acquisitions although some off-resonance blurring can sometimes be seen in the spiral acquisitions, despite the short spiral readout durations (e.g. inferolateral wall of the RV in patient 1). This may be improved using spatially varying off-resonance correction. Figure 2 shows basal slices from a patient with enhancement in the septum which is more defined on the 3D spiral image due to better through-plane resolution and a reduced AW. A higher through-plane resolution 3D spiral image is also shown for comparison. Spiral 3D scans had mean acquisition duration 83 s (51-144 s), allowing for multiple repetitions or high resolution examination of regions of enhancement in similar duration as the 2D stack with 8 slices taking ~240 s; shorter AWs may also have reduced motion blurring.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Clinical assessment of the viability of myocardium is commonly performed using 2D breath-hold late gadolinium enhancement (LGE) imaging with Cartesian k-space coverage and data acquisition windows (AWs) ranging from 140-200 ms... More efficient k-space coverage using spiral trajectories could allow improved spatial resolution and reduced AWs without greatly extending acquisition durations... To this end, we have developed a navigator-gated spiral 3D LGE sequence and present the results in 10 patients attending for clinical 2D LGE imaging on a 3T Siemens Skyra scanner... Acquisition duration was 34 cardiac cycles assuming 100% respiratory efficiency (alternate R-wave gating). 3D imaging was performed after the acquisition of a stack of conventional clinical breath-hold 2D LGE images in 10 patients (acquired resolution: 1.4 × 1.8 mm reconstructed to 0.7 × 0.7 mm)... The 2D images had slice thickness of 7 mm with slice gap of 3 mm... Acquisition duration was 14 cardiac cycles per slice (alternate R-wave gating)... LV blood SNR and blood-myocardium CNR in conventional 2D and spiral 3D scans were compared in 3 matched slices (basal, mid and apical) using paired Wilcoxon signed rank test... SNR measurements were significantly higher and CNR were borderline significantly higher for the 3D spiral compared to the 2D scans (SNR: 10.96 ± 2.71 vs 13.59 ± 4.70 (p < 0.01); CNR: 9.23 ± 2.60 vs 10.52 ± 4.00 (p = 0.06))... Figure 1 shows images from 2 example patients... Image quality over the LV is similar for 2D Cartesian and 3D spiral acquisitions although some off-resonance blurring can sometimes be seen in the spiral acquisitions, despite the short spiral readout durations (e.g. inferolateral wall of the RV in patient 1)... This may be improved using spatially varying off-resonance correction... Spiral 3D scans had mean acquisition duration 83 s (51-144 s), allowing for multiple repetitions or high resolution examination of regions of enhancement in similar duration as the 2D stack with 8 slices taking ~240 s; shorter AWs may also have reduced motion blurring... Navigator-gated 3D spiral LGE imaging allows contiguous coverage of the LV with higher spatial resolution, shorter acquisition windows and reduced acquisition durations when compared to a stack of conventional breath-hold 2D LGE Cartesian acquisitions.

No MeSH data available.


Related in: MedlinePlus