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Right ventricular kinetic energy: 4D flow MRI analysis of healthy volunteers and repaired Tetralogy of Fallot

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The aim of this study was to demonstrate the feasibility of calculating KERV with 4D Flow MRI and assess differences between rTOF and healthy volunteers... Differences in peak systolic and diastolic KERV and the QMPA/KERV ratio, an indicator of RV-MPA coupling, between groups were assessed using the Wilcoxon rank-sum test... Three distinct KE peaks were observed in all subjects... Peak systolic (p = 0.0076) and diastolic (p = 0.0003 peak 1, p = 0.013 peak 2) were higher in rTOF than in healthy volunteers (Figures 1,2)... The QMPA/KERV ratio was lower in rTOF (0.92 +/- 0.68 ml/cycle*mJ) than in healthy volunteers (6.92 +/- 4.16, p = 0.0002)... Time-resolved KERV was measured in rTOF and healthy volunteers using 4D flow MRI... KERV was higher and QMPA/KERV ratio was lower in rTOF than in healthy volunteers, indicative of greater inefficiency in RV function to generate the same cardiac output... Future studies are needed to determine if changes in RV KE provide earlier evidence of RV dysfunction and need for reintervention than standard CMR measurements.

No MeSH data available.


RV KE throughout cardiac cycle for a representative subject from rTOF and healthy volunteer groups. Three distinct KE peaks were observed in all subjects.
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Figure 2: RV KE throughout cardiac cycle for a representative subject from rTOF and healthy volunteer groups. Three distinct KE peaks were observed in all subjects.

Mentions: Three distinct KE peaks were observed in all subjects. Peak systolic (p = 0.0076) and diastolic (p = 0.0003 peak 1, p = 0.013 peak 2) were higher in rTOF than in healthy volunteers (Figures 1,2). The QMPA/KERV ratio was lower in rTOF (0.92 +/- 0.68 ml/cycle*mJ) than in healthy volunteers (6.92 +/- 4.16, p = 0.0002).


Right ventricular kinetic energy: 4D flow MRI analysis of healthy volunteers and repaired Tetralogy of Fallot
RV KE throughout cardiac cycle for a representative subject from rTOF and healthy volunteer groups. Three distinct KE peaks were observed in all subjects.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4045693&req=5

Figure 2: RV KE throughout cardiac cycle for a representative subject from rTOF and healthy volunteer groups. Three distinct KE peaks were observed in all subjects.
Mentions: Three distinct KE peaks were observed in all subjects. Peak systolic (p = 0.0076) and diastolic (p = 0.0003 peak 1, p = 0.013 peak 2) were higher in rTOF than in healthy volunteers (Figures 1,2). The QMPA/KERV ratio was lower in rTOF (0.92 +/- 0.68 ml/cycle*mJ) than in healthy volunteers (6.92 +/- 4.16, p = 0.0002).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The aim of this study was to demonstrate the feasibility of calculating KERV with 4D Flow MRI and assess differences between rTOF and healthy volunteers... Differences in peak systolic and diastolic KERV and the QMPA/KERV ratio, an indicator of RV-MPA coupling, between groups were assessed using the Wilcoxon rank-sum test... Three distinct KE peaks were observed in all subjects... Peak systolic (p = 0.0076) and diastolic (p = 0.0003 peak 1, p = 0.013 peak 2) were higher in rTOF than in healthy volunteers (Figures 1,2)... The QMPA/KERV ratio was lower in rTOF (0.92 +/- 0.68 ml/cycle*mJ) than in healthy volunteers (6.92 +/- 4.16, p = 0.0002)... Time-resolved KERV was measured in rTOF and healthy volunteers using 4D flow MRI... KERV was higher and QMPA/KERV ratio was lower in rTOF than in healthy volunteers, indicative of greater inefficiency in RV function to generate the same cardiac output... Future studies are needed to determine if changes in RV KE provide earlier evidence of RV dysfunction and need for reintervention than standard CMR measurements.

No MeSH data available.