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Preliminary application of in vivo cardiac diffusion weighted MRI in chronic myocardial infarction porcine model

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Cardiac diffusion-weighted MRI is a non-contrast technique that has the potential to identify changes in tissue microstructure in acute myocardial infarction (MI) in humans and rats... The trace apparent diffusion coefficient (trADC) was found to be significantly increased in the infarcted region relative to remote regions... The increased trADC is attributed to an increase in extracellular space following cell death, where restriction in water diffusion is less... The aim of this study was to perform in vivo cardiac diffusion-weighted MRI in a chronic MI porcine model to see if this increased trADC chronically persists and correlate it with scar tissue delineated by late gadolinium enhancement (LGE) imaging... Four chronic MI (8 weeks post MI induced by completely occluded proximal LAD) mini pigs were scanned on a 3T MR system (Siemens Verio)... Contrast LGE GRE imaging was performed roughly 15 min post contrast injection (TR/TE/TI = 326/1.47/300 ms, α = 20°, 1.3 × 1.3 × 8 mm, 12 slices)... The lateral wall of the most basal slice (furthest from the LAD occlusion) was designated as the remote region... The region of infarction was determined by elevated trADC and signal intensity in LGE (both required μinfarct >μremote + 5σremote)... The infarct area determined by elevated trADC was compared to the LGE infarct area... The location of elevated trADC infarct region agreed well with the LGE infarct area... In this preliminary study, infarct regions delineated by elevated trADC correlated well with infarct regions defined by protocol matched LGE in area size and location... The roughly 50% increase in trADC values found in the infarct region relative to the remote region was statistically significant... Further histological studies and larger sample size are needed to confirm the origin of the increase in trADC and its relationship with infarcted tissue.

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Pulse sequence diagram. (a) The longest quiescent period is found using CINE imaging and (b) the motion compensated diffusion prep and segmented TSE readout is placed during this period. In the case the quiescent period is too short to fit both the prep and the readout, the diffusion prep was prioritized and the number of shots were increased. The bulk motion compensated diffusion prep (c) is m1 and m2 compensated and a non-selective adiabatic BIR-4 was used. The magnetization was allowed to recover for 2 RR after the TSE acquisition.
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Figure 1: Pulse sequence diagram. (a) The longest quiescent period is found using CINE imaging and (b) the motion compensated diffusion prep and segmented TSE readout is placed during this period. In the case the quiescent period is too short to fit both the prep and the readout, the diffusion prep was prioritized and the number of shots were increased. The bulk motion compensated diffusion prep (c) is m1 and m2 compensated and a non-selective adiabatic BIR-4 was used. The magnetization was allowed to recover for 2 RR after the TSE acquisition.


Preliminary application of in vivo cardiac diffusion weighted MRI in chronic myocardial infarction porcine model
Pulse sequence diagram. (a) The longest quiescent period is found using CINE imaging and (b) the motion compensated diffusion prep and segmented TSE readout is placed during this period. In the case the quiescent period is too short to fit both the prep and the readout, the diffusion prep was prioritized and the number of shots were increased. The bulk motion compensated diffusion prep (c) is m1 and m2 compensated and a non-selective adiabatic BIR-4 was used. The magnetization was allowed to recover for 2 RR after the TSE acquisition.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4044171&req=5

Figure 1: Pulse sequence diagram. (a) The longest quiescent period is found using CINE imaging and (b) the motion compensated diffusion prep and segmented TSE readout is placed during this period. In the case the quiescent period is too short to fit both the prep and the readout, the diffusion prep was prioritized and the number of shots were increased. The bulk motion compensated diffusion prep (c) is m1 and m2 compensated and a non-selective adiabatic BIR-4 was used. The magnetization was allowed to recover for 2 RR after the TSE acquisition.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Cardiac diffusion-weighted MRI is a non-contrast technique that has the potential to identify changes in tissue microstructure in acute myocardial infarction (MI) in humans and rats... The trace apparent diffusion coefficient (trADC) was found to be significantly increased in the infarcted region relative to remote regions... The increased trADC is attributed to an increase in extracellular space following cell death, where restriction in water diffusion is less... The aim of this study was to perform in vivo cardiac diffusion-weighted MRI in a chronic MI porcine model to see if this increased trADC chronically persists and correlate it with scar tissue delineated by late gadolinium enhancement (LGE) imaging... Four chronic MI (8 weeks post MI induced by completely occluded proximal LAD) mini pigs were scanned on a 3T MR system (Siemens Verio)... Contrast LGE GRE imaging was performed roughly 15 min post contrast injection (TR/TE/TI = 326/1.47/300 ms, α = 20°, 1.3 × 1.3 × 8 mm, 12 slices)... The lateral wall of the most basal slice (furthest from the LAD occlusion) was designated as the remote region... The region of infarction was determined by elevated trADC and signal intensity in LGE (both required μinfarct >μremote + 5σremote)... The infarct area determined by elevated trADC was compared to the LGE infarct area... The location of elevated trADC infarct region agreed well with the LGE infarct area... In this preliminary study, infarct regions delineated by elevated trADC correlated well with infarct regions defined by protocol matched LGE in area size and location... The roughly 50% increase in trADC values found in the infarct region relative to the remote region was statistically significant... Further histological studies and larger sample size are needed to confirm the origin of the increase in trADC and its relationship with infarcted tissue.

No MeSH data available.