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3D free-breathing late gadolinium enhancement 3T MRI: comparison with standard 2D Imaging

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Clinical cardiovascular magnetic resonance imaging (CMR) is routinely performed during multiple breath-holds in predefined 2D image orientations. 3D CMR is desirable, since it allows post-acquisition reformatting in any desired imaging plane... Therefore, the purpose of the present study was to develop and clinically test 3D free-breathing PSIR LGE CMR using a respiratory navigator approach at 3T in comparison to a standard 2D breath-hold sequence... In patients with a clinical indication for LGE imaging, both 3D and 2D PSIR sequences were acquired after administration of Dotarem (Guerbet) between May 2012 and June 2013... Myocardial scar tissue volume (ml), SNR, CNR and edge sharpness (ES) between healthy and scarred myocardium were quantified... Parameters were compared using a paired t-test... Figure 2 shows an example of short axis slices in 2D and analogous reconstructed slices from the 3D sequence... Myocardial scar tissue volume (3D: 27.11 ± 17.94; 2D: 29.50 ± 15.43 ml; p = 0.49), SNR (3D: 100.88 ± 31.97; 2D: 89.92 ± 18.57; p = 0.06) and CNR (3D: 3.96 ± 1.84; 2D: 3.55 ± 0.68; p = 0.25) were not significantly different between 3D and 2D sequences... However, ES was significantly higher for 3D CMR (3D: 0.051 ± 0.0072; 2D: 0.048 ± 0.0085; p = 0.019)... Free-breathing 3D LGE CMR of myocardial scar tissue is feasible at 3T, with improved edge sharpness as compared to a standard 2D breath-hold PSIR sequence.

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Short-axis views of 2D and 3D sequences of a 58 year old man 2 weeks after an acute myocardial infarction with occlusion of the left anterior descending artery showing transmural delayed enhancement in septal and anterior segments. Also note the necrotic core.
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Figure 2: Short-axis views of 2D and 3D sequences of a 58 year old man 2 weeks after an acute myocardial infarction with occlusion of the left anterior descending artery showing transmural delayed enhancement in septal and anterior segments. Also note the necrotic core.

Mentions: Figure 2 shows an example of short axis slices in 2D and analogous reconstructed slices from the 3D sequence. Myocardial scar tissue volume (3D: 27.11 ± 17.94; 2D: 29.50 ± 15.43 ml; p = 0.49), SNR (3D: 100.88 ± 31.97; 2D: 89.92 ± 18.57; p = 0.06) and CNR (3D: 3.96 ± 1.84; 2D: 3.55 ± 0.68; p = 0.25) were not significantly different between 3D and 2D sequences. However, ES was significantly higher for 3D CMR (3D: 0.051 ± 0.0072; 2D: 0.048 ± 0.0085; p = 0.019).


3D free-breathing late gadolinium enhancement 3T MRI: comparison with standard 2D Imaging
Short-axis views of 2D and 3D sequences of a 58 year old man 2 weeks after an acute myocardial infarction with occlusion of the left anterior descending artery showing transmural delayed enhancement in septal and anterior segments. Also note the necrotic core.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4044116&req=5

Figure 2: Short-axis views of 2D and 3D sequences of a 58 year old man 2 weeks after an acute myocardial infarction with occlusion of the left anterior descending artery showing transmural delayed enhancement in septal and anterior segments. Also note the necrotic core.
Mentions: Figure 2 shows an example of short axis slices in 2D and analogous reconstructed slices from the 3D sequence. Myocardial scar tissue volume (3D: 27.11 ± 17.94; 2D: 29.50 ± 15.43 ml; p = 0.49), SNR (3D: 100.88 ± 31.97; 2D: 89.92 ± 18.57; p = 0.06) and CNR (3D: 3.96 ± 1.84; 2D: 3.55 ± 0.68; p = 0.25) were not significantly different between 3D and 2D sequences. However, ES was significantly higher for 3D CMR (3D: 0.051 ± 0.0072; 2D: 0.048 ± 0.0085; p = 0.019).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Clinical cardiovascular magnetic resonance imaging (CMR) is routinely performed during multiple breath-holds in predefined 2D image orientations. 3D CMR is desirable, since it allows post-acquisition reformatting in any desired imaging plane... Therefore, the purpose of the present study was to develop and clinically test 3D free-breathing PSIR LGE CMR using a respiratory navigator approach at 3T in comparison to a standard 2D breath-hold sequence... In patients with a clinical indication for LGE imaging, both 3D and 2D PSIR sequences were acquired after administration of Dotarem (Guerbet) between May 2012 and June 2013... Myocardial scar tissue volume (ml), SNR, CNR and edge sharpness (ES) between healthy and scarred myocardium were quantified... Parameters were compared using a paired t-test... Figure 2 shows an example of short axis slices in 2D and analogous reconstructed slices from the 3D sequence... Myocardial scar tissue volume (3D: 27.11 ± 17.94; 2D: 29.50 ± 15.43 ml; p = 0.49), SNR (3D: 100.88 ± 31.97; 2D: 89.92 ± 18.57; p = 0.06) and CNR (3D: 3.96 ± 1.84; 2D: 3.55 ± 0.68; p = 0.25) were not significantly different between 3D and 2D sequences... However, ES was significantly higher for 3D CMR (3D: 0.051 ± 0.0072; 2D: 0.048 ± 0.0085; p = 0.019)... Free-breathing 3D LGE CMR of myocardial scar tissue is feasible at 3T, with improved edge sharpness as compared to a standard 2D breath-hold PSIR sequence.

No MeSH data available.


Related in: MedlinePlus