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Interaction of obesity and central obesity on elevated urinary albumin-to-creatinine ratio.

Du N, Peng H, Chao X, Zhang Q, Tian H, Li H - PLoS ONE (2014)

Bottom Line: After controlling for potential covariates, participants with both obesity and central obesity have significantly increased risk for elevated UACR (OR = 1.82 P<0.001) compared to those with neither.The multipliable interactive effect between obesity and central obesity on elevated UACR was not found significant (OR = 1.82, P = 0.078).Microalbuminuria was significantly associated with the interaction between obesity and central obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.

ABSTRACT

Background: Microalbuminuria was much more common among obese individuals indicating a probable association with obesity. However, association of microalbuminuria with interaction between obesity and central obesity has not yet been studied.

Design and methods: A cross-sectional study was conducted in a 2889 general population aged ≥ 30 years. Obesity was defined as body mass index ≥ 28.0 kg/m2 and central obesity was defined as waist-to-hip ratio ≥ 0.85 for females and ≥ 0.90 for males. Both additive and multipliable interactions between obesity and central obesity on elevated urinary albumin-to-creatinine ratio (UACR) were evaluated.

Results: After controlling for potential covariates, participants with both obesity and central obesity have significantly increased risk for elevated UACR (OR = 1.82 P<0.001) compared to those with neither. Additive interaction analysis indicated that about 43.9% of the risk of elevated UACR in participants with both obesity and central obesity was attributed to the interaction between obesity and central obesity (the attributable proportion because of the interaction: 0.439; 95% CI: 0.110-0.768). The multipliable interactive effect between obesity and central obesity on elevated UACR was not found significant (OR = 1.82, P = 0.078).

Conclusions: Microalbuminuria was significantly associated with the interaction between obesity and central obesity. Our results indicated that individuals with both obesity and central obesity should be intensively managed to prevent renal diseases.

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Distribution of elevated urinary albumin-to-creatinine ratio in obese and/or central obese participants.
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pone-0098926-g001: Distribution of elevated urinary albumin-to-creatinine ratio in obese and/or central obese participants.

Mentions: All subjects were stratified into three categories by BMI, and then each category was divided into two groups: with and without central obesity, the prevalence of elevated UACR was calculated in each subgroup (Figure 1). In all BMI subgroups, prevalences of elevated UACR were significantly higher in participants with central obesity than those with normal WHR (all P values <0.001). Moreover, with the increase of BMI level, the prevalence of elevated UACR positively increased in participants with central obesity (P<0.001 for trend), which indicated a possible interaction between obesity and central obesity.


Interaction of obesity and central obesity on elevated urinary albumin-to-creatinine ratio.

Du N, Peng H, Chao X, Zhang Q, Tian H, Li H - PLoS ONE (2014)

Distribution of elevated urinary albumin-to-creatinine ratio in obese and/or central obese participants.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043988&req=5

pone-0098926-g001: Distribution of elevated urinary albumin-to-creatinine ratio in obese and/or central obese participants.
Mentions: All subjects were stratified into three categories by BMI, and then each category was divided into two groups: with and without central obesity, the prevalence of elevated UACR was calculated in each subgroup (Figure 1). In all BMI subgroups, prevalences of elevated UACR were significantly higher in participants with central obesity than those with normal WHR (all P values <0.001). Moreover, with the increase of BMI level, the prevalence of elevated UACR positively increased in participants with central obesity (P<0.001 for trend), which indicated a possible interaction between obesity and central obesity.

Bottom Line: After controlling for potential covariates, participants with both obesity and central obesity have significantly increased risk for elevated UACR (OR = 1.82 P<0.001) compared to those with neither.The multipliable interactive effect between obesity and central obesity on elevated UACR was not found significant (OR = 1.82, P = 0.078).Microalbuminuria was significantly associated with the interaction between obesity and central obesity.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.

ABSTRACT

Background: Microalbuminuria was much more common among obese individuals indicating a probable association with obesity. However, association of microalbuminuria with interaction between obesity and central obesity has not yet been studied.

Design and methods: A cross-sectional study was conducted in a 2889 general population aged ≥ 30 years. Obesity was defined as body mass index ≥ 28.0 kg/m2 and central obesity was defined as waist-to-hip ratio ≥ 0.85 for females and ≥ 0.90 for males. Both additive and multipliable interactions between obesity and central obesity on elevated urinary albumin-to-creatinine ratio (UACR) were evaluated.

Results: After controlling for potential covariates, participants with both obesity and central obesity have significantly increased risk for elevated UACR (OR = 1.82 P<0.001) compared to those with neither. Additive interaction analysis indicated that about 43.9% of the risk of elevated UACR in participants with both obesity and central obesity was attributed to the interaction between obesity and central obesity (the attributable proportion because of the interaction: 0.439; 95% CI: 0.110-0.768). The multipliable interactive effect between obesity and central obesity on elevated UACR was not found significant (OR = 1.82, P = 0.078).

Conclusions: Microalbuminuria was significantly associated with the interaction between obesity and central obesity. Our results indicated that individuals with both obesity and central obesity should be intensively managed to prevent renal diseases.

Show MeSH
Related in: MedlinePlus