Limits...
Synthetic LGE derived from cardiac T 1 mapping for simultaneous assessment of focal and diffuse cardiac fibrosis

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

While late gadolinium enhanced (LGE) MRI is the gold standard for detection of focal myocardial scarring, it is less effective than cardiac T1 mapping (ECV) for detection of diffuse fibrosis... We imaged 6 mongrel dogs with lesions created by RF ablation on a 3T MRI system (Verio, Siemens), using arrhythmia-insensitive-rapid (AIR) cardiac T1 mapping and standard LGE MRI during equilibrium of Gd-BOPTA (slow infusion at 0.002 mmol/kg/min), in order to compare standard and synthetic LGE images acquired at identical concentration of Gd-BOPTA... Both LGE MRI and cardiac T1 mapping were acquired with identical spatial resolution = 1.4×1.4×7 mm... Figure 1 shows representative standard and synthetic LGE images with a lesion... The two LGE images showed comparable image quality... As summarized in Table 1, synthetic LGE yielded higher (p < 0.001) contrast ratio of the lesion-myocardium and blood-myocardium pairs than standard LGE, but the magnitude of the differences was less than 10%... We propose a new approach to simultaneously assess focal and diffuse cardiac fibrosis using cardiac T1 mapping, with no need for separate acquisition of standard LGE images... This approach is also compatible with inversion-recovery based cardiac T1 mapping methods... Synthetic LGE derived from T1 mapping may be particularly useful for infarct size and area at risk calculations, because it is inherently insensitive to signal variation due to confounders such as RF excitation and receive inhomogeneities.

No MeSH data available.


Comparison (left) standard LGE with (middle) synthetic LGE derived from (right) T1 map. Red arrows point to RF ablation lesion created hours before with a catheter.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4043984&req=5

Figure 1: Comparison (left) standard LGE with (middle) synthetic LGE derived from (right) T1 map. Red arrows point to RF ablation lesion created hours before with a catheter.

Mentions: Our pooled data contained 21 short-axis planes with different RF lesions. Figure 1 shows representative standard and synthetic LGE images with a lesion. The two LGE images showed comparable image quality. As summarized in Table 1, synthetic LGE yielded higher (p < 0.001) contrast ratio of the lesion-myocardium and blood-myocardium pairs than standard LGE, but the magnitude of the differences was less than 10%.


Synthetic LGE derived from cardiac T 1 mapping for simultaneous assessment of focal and diffuse cardiac fibrosis
Comparison (left) standard LGE with (middle) synthetic LGE derived from (right) T1 map. Red arrows point to RF ablation lesion created hours before with a catheter.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4043984&req=5

Figure 1: Comparison (left) standard LGE with (middle) synthetic LGE derived from (right) T1 map. Red arrows point to RF ablation lesion created hours before with a catheter.
Mentions: Our pooled data contained 21 short-axis planes with different RF lesions. Figure 1 shows representative standard and synthetic LGE images with a lesion. The two LGE images showed comparable image quality. As summarized in Table 1, synthetic LGE yielded higher (p < 0.001) contrast ratio of the lesion-myocardium and blood-myocardium pairs than standard LGE, but the magnitude of the differences was less than 10%.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

While late gadolinium enhanced (LGE) MRI is the gold standard for detection of focal myocardial scarring, it is less effective than cardiac T1 mapping (ECV) for detection of diffuse fibrosis... We imaged 6 mongrel dogs with lesions created by RF ablation on a 3T MRI system (Verio, Siemens), using arrhythmia-insensitive-rapid (AIR) cardiac T1 mapping and standard LGE MRI during equilibrium of Gd-BOPTA (slow infusion at 0.002 mmol/kg/min), in order to compare standard and synthetic LGE images acquired at identical concentration of Gd-BOPTA... Both LGE MRI and cardiac T1 mapping were acquired with identical spatial resolution = 1.4×1.4×7 mm... Figure 1 shows representative standard and synthetic LGE images with a lesion... The two LGE images showed comparable image quality... As summarized in Table 1, synthetic LGE yielded higher (p < 0.001) contrast ratio of the lesion-myocardium and blood-myocardium pairs than standard LGE, but the magnitude of the differences was less than 10%... We propose a new approach to simultaneously assess focal and diffuse cardiac fibrosis using cardiac T1 mapping, with no need for separate acquisition of standard LGE images... This approach is also compatible with inversion-recovery based cardiac T1 mapping methods... Synthetic LGE derived from T1 mapping may be particularly useful for infarct size and area at risk calculations, because it is inherently insensitive to signal variation due to confounders such as RF excitation and receive inhomogeneities.

No MeSH data available.