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Ventricular growth, measured by cardiac MRI, is not different in patients with tetralogy of fallot versus pulmonary atresia with intact ventricular septum or critical pulmonary stenosis after right ventricular outflow tract reconstruction

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Cardiac MRI is used to measure right ventricular end diastolic volume indexed to body surface area (RVEDVi) and ejection fraction (EF) in the setting of pulmonary insufficiency (PI)... A subset of these patients undergo initial palliation with right ventricular outflow tract reconstruction to allow for antegrade flow across the pulmonary valve and PI to encourage RV growth over time... The lack of data concerning RV growth in this population may lead to mistimed valve replacement such that RV systolic or diastolic function is permanently compromised... Hypothesis: RVEDVi growth will be different between patients with TOF and PAIVS/CPS; and systolic function will be decreased at equivalent volumes in the PAIVS/critical PS group... Two groups of patients were studied for RV size by MRI volumetric measurement: Group 1 were patients with TOF s/p repair and residual PI, Group 2 was comprised of patients with PAIVS or CPS with HRV who underwent RVOT reconstruction... The groups were well matched for height, weight and BSA, while there was a trend toward younger age in the PAIVS group (P = 0.06)... The RVEDVi, RVESVi and RVEF of patients with PA/IVS-CPS and TOF were not significantly different (P = 0.12, 0.15, and 0.49 respectively)... RVEDVi was plotted against age and there was no difference in slope of the regression lines, suggesting similar growth of the RV between PAIVS-CPS and TOF, which was consistent with limited longitudinal data (Figure 1)... RV regurgitant fraction, LVEF and RV:LV EDV ratio were independent predictors of RVEF in both groups (Table 1)... RV growth and systolic function is similar between a PA/IVS-critical PS group and TOF group after RV outflow tract reconstruction... There is significant RV:LV interaction driving RV systolic function in both groups.

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The top panel demonstrates RVEDVi vs Age utilizing cross-sectional data for two patient groups: Tetralogy of Fallot s/p repair and PA/IVS or critical pulmonary stenosis with hypoplastic right ventricle s/p RV outflow tract reconstruction. The lower panel shows longitudinal growth in a subset of patients for which data was available.
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Figure 1: The top panel demonstrates RVEDVi vs Age utilizing cross-sectional data for two patient groups: Tetralogy of Fallot s/p repair and PA/IVS or critical pulmonary stenosis with hypoplastic right ventricle s/p RV outflow tract reconstruction. The lower panel shows longitudinal growth in a subset of patients for which data was available.

Mentions: 114 patients with TOF and 25 patients with PA/IVS-CPS had data reviewed spanning a period of 14 years. The groups were well matched for height, weight and BSA, while there was a trend toward younger age in the PAIVS group (P = 0.06). The RVEDVi, RVESVi and RVEF of patients with PA/IVS-CPS and TOF were not significantly different (P = 0.12, 0.15, and 0.49 respectively). RVEDVi was plotted against age and there was no difference in slope of the regression lines, suggesting similar growth of the RV between PAIVS-CPS and TOF, which was consistent with limited longitudinal data (Figure 1). RV regurgitant fraction, LVEF and RV:LV EDV ratio were independent predictors of RVEF in both groups (Table 1).


Ventricular growth, measured by cardiac MRI, is not different in patients with tetralogy of fallot versus pulmonary atresia with intact ventricular septum or critical pulmonary stenosis after right ventricular outflow tract reconstruction
The top panel demonstrates RVEDVi vs Age utilizing cross-sectional data for two patient groups: Tetralogy of Fallot s/p repair and PA/IVS or critical pulmonary stenosis with hypoplastic right ventricle s/p RV outflow tract reconstruction. The lower panel shows longitudinal growth in a subset of patients for which data was available.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4043977&req=5

Figure 1: The top panel demonstrates RVEDVi vs Age utilizing cross-sectional data for two patient groups: Tetralogy of Fallot s/p repair and PA/IVS or critical pulmonary stenosis with hypoplastic right ventricle s/p RV outflow tract reconstruction. The lower panel shows longitudinal growth in a subset of patients for which data was available.
Mentions: 114 patients with TOF and 25 patients with PA/IVS-CPS had data reviewed spanning a period of 14 years. The groups were well matched for height, weight and BSA, while there was a trend toward younger age in the PAIVS group (P = 0.06). The RVEDVi, RVESVi and RVEF of patients with PA/IVS-CPS and TOF were not significantly different (P = 0.12, 0.15, and 0.49 respectively). RVEDVi was plotted against age and there was no difference in slope of the regression lines, suggesting similar growth of the RV between PAIVS-CPS and TOF, which was consistent with limited longitudinal data (Figure 1). RV regurgitant fraction, LVEF and RV:LV EDV ratio were independent predictors of RVEF in both groups (Table 1).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Cardiac MRI is used to measure right ventricular end diastolic volume indexed to body surface area (RVEDVi) and ejection fraction (EF) in the setting of pulmonary insufficiency (PI)... A subset of these patients undergo initial palliation with right ventricular outflow tract reconstruction to allow for antegrade flow across the pulmonary valve and PI to encourage RV growth over time... The lack of data concerning RV growth in this population may lead to mistimed valve replacement such that RV systolic or diastolic function is permanently compromised... Hypothesis: RVEDVi growth will be different between patients with TOF and PAIVS/CPS; and systolic function will be decreased at equivalent volumes in the PAIVS/critical PS group... Two groups of patients were studied for RV size by MRI volumetric measurement: Group 1 were patients with TOF s/p repair and residual PI, Group 2 was comprised of patients with PAIVS or CPS with HRV who underwent RVOT reconstruction... The groups were well matched for height, weight and BSA, while there was a trend toward younger age in the PAIVS group (P = 0.06)... The RVEDVi, RVESVi and RVEF of patients with PA/IVS-CPS and TOF were not significantly different (P = 0.12, 0.15, and 0.49 respectively)... RVEDVi was plotted against age and there was no difference in slope of the regression lines, suggesting similar growth of the RV between PAIVS-CPS and TOF, which was consistent with limited longitudinal data (Figure 1)... RV regurgitant fraction, LVEF and RV:LV EDV ratio were independent predictors of RVEF in both groups (Table 1)... RV growth and systolic function is similar between a PA/IVS-critical PS group and TOF group after RV outflow tract reconstruction... There is significant RV:LV interaction driving RV systolic function in both groups.

No MeSH data available.


Related in: MedlinePlus