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Suboptimal vitamin D status in a population-based study of Asian children: prevalence and relation to allergic diseases and atopy.

Yao TC, Tu YL, Chang SW, Tsai HJ, Gu PW, Ning HC, Hua MC, Liao SL, Tsai MH, Chiu CY, Lai SH, Yeh KW, Huang JL, PATCH study groupHuang JL - PLoS ONE (2014)

Bottom Line: After adjusting for potential confounders, serum 25(OH)D status had no association with asthma, rhinitis, eczema, atopy, or total serum IgE (all P>0.05).Low serum 25(OH)D levels are remarkably common in this population sample of Asian children, suggesting that millions of children living in Taiwan may have suboptimal levels of vitamin D, which should be a matter of public health concern.Our results provides epidemiological evidence against the association of vitamin D status with various allergic diseases and atopy in Asian children.

View Article: PubMed Central - PubMed

Affiliation: Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.

ABSTRACT

Background: New evidence shows high prevalence of vitamin D deficiency in many countries and some studies suggest a possible link between vitamin D status and allergic diseases. The objectives of this study were to determine the prevalence of suboptimal vitamin D status in a population sample of Asian children and to investigate the relationship of vitamin D status with allergic diseases and atopy.

Methods: Children aged 5-18 years (N = 1315) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were evaluated using questionnaires, anthropometric measurements, and serum levels of 25-hydroxyvitamin D [25(OH)D] and total and specific immunoglobulin E (IgE).

Results: The mean concentration of serum 25(OH)D was 20.4 ng/mL (SD: 7.1 ng/mL). Vitamin D deficiency (defined as serum 25(OH)D<20 ng/mL) was present in 670 subjects (51.0%), while vitamin D insufficiency (defined as serum 25(OH)D<30 ng/mL) was observed in 1187 subjects (90.3%). Older age (P<0.001), female gender (P<0.001), higher body mass index (P = 0.001), winter and spring seasons (compared to summer; P both<0.001), and passive smoking (P = 0.011) were independently associated with low serum 25(OH)D levels. After adjusting for potential confounders, serum 25(OH)D status had no association with asthma, rhinitis, eczema, atopy, or total serum IgE (all P>0.05).

Conclusions: Low serum 25(OH)D levels are remarkably common in this population sample of Asian children, suggesting that millions of children living in Taiwan may have suboptimal levels of vitamin D, which should be a matter of public health concern. Our results provides epidemiological evidence against the association of vitamin D status with various allergic diseases and atopy in Asian children.

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Related in: MedlinePlus

Schematic presentation of the recruitment process of the study subjects.
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pone-0099105-g001: Schematic presentation of the recruitment process of the study subjects.

Mentions: The Prediction of Allergies in Taiwanese CHildren (PATCH) study is a population-based prospective cohort study that was launched in 2007 in Keelung (25°N latitude), Taiwan, to investigate the epidemiology and predictive factors of asthma and allergies in children. Detailed descriptions of subject recruitment and data collection have been reported previously [8], [16], [17], [18], [19]. The subject flow diagram of the current study is presented in Figure 1. Briefly, study subjects were enrolled from a school-based sample of 5351 children (2616 boys, 48.9%; age, 10.4±2.9 years) in an International Study of Asthma and Allergies in Childhood (ISAAC) epidemiologic survey. Thereafter, a random sample of 1,900 subjects were invited to undergo a thorough examination and 1717 agreed to participate, representing an overall participation rate of 90.4%. Parents of all study subjects answered a questionnaire regarding demographic data, general health information, and questions related to clinical symptoms and diagnosis of allergic diseases. Serum levels of 25-hydroxyvitamin D [25(OH)D)] and allergen-specific IgE were measured in 1315 subjects whose parents agreed to blood sampling. There was no significant difference in terms of age, sex, and prevalence of allergic diseases between these 1315 subjects who provided blood samples and the original 5351 cohort members, indicating a sampling cohort representative of the general population. All subjects were born to parents who were Asian descent. The Institutional Review Board of Chang Gung Medical Foundation approved the study. The parents of all subjects provided written informed consent on behalf of their children.


Suboptimal vitamin D status in a population-based study of Asian children: prevalence and relation to allergic diseases and atopy.

Yao TC, Tu YL, Chang SW, Tsai HJ, Gu PW, Ning HC, Hua MC, Liao SL, Tsai MH, Chiu CY, Lai SH, Yeh KW, Huang JL, PATCH study groupHuang JL - PLoS ONE (2014)

Schematic presentation of the recruitment process of the study subjects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043968&req=5

pone-0099105-g001: Schematic presentation of the recruitment process of the study subjects.
Mentions: The Prediction of Allergies in Taiwanese CHildren (PATCH) study is a population-based prospective cohort study that was launched in 2007 in Keelung (25°N latitude), Taiwan, to investigate the epidemiology and predictive factors of asthma and allergies in children. Detailed descriptions of subject recruitment and data collection have been reported previously [8], [16], [17], [18], [19]. The subject flow diagram of the current study is presented in Figure 1. Briefly, study subjects were enrolled from a school-based sample of 5351 children (2616 boys, 48.9%; age, 10.4±2.9 years) in an International Study of Asthma and Allergies in Childhood (ISAAC) epidemiologic survey. Thereafter, a random sample of 1,900 subjects were invited to undergo a thorough examination and 1717 agreed to participate, representing an overall participation rate of 90.4%. Parents of all study subjects answered a questionnaire regarding demographic data, general health information, and questions related to clinical symptoms and diagnosis of allergic diseases. Serum levels of 25-hydroxyvitamin D [25(OH)D)] and allergen-specific IgE were measured in 1315 subjects whose parents agreed to blood sampling. There was no significant difference in terms of age, sex, and prevalence of allergic diseases between these 1315 subjects who provided blood samples and the original 5351 cohort members, indicating a sampling cohort representative of the general population. All subjects were born to parents who were Asian descent. The Institutional Review Board of Chang Gung Medical Foundation approved the study. The parents of all subjects provided written informed consent on behalf of their children.

Bottom Line: After adjusting for potential confounders, serum 25(OH)D status had no association with asthma, rhinitis, eczema, atopy, or total serum IgE (all P>0.05).Low serum 25(OH)D levels are remarkably common in this population sample of Asian children, suggesting that millions of children living in Taiwan may have suboptimal levels of vitamin D, which should be a matter of public health concern.Our results provides epidemiological evidence against the association of vitamin D status with various allergic diseases and atopy in Asian children.

View Article: PubMed Central - PubMed

Affiliation: Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.

ABSTRACT

Background: New evidence shows high prevalence of vitamin D deficiency in many countries and some studies suggest a possible link between vitamin D status and allergic diseases. The objectives of this study were to determine the prevalence of suboptimal vitamin D status in a population sample of Asian children and to investigate the relationship of vitamin D status with allergic diseases and atopy.

Methods: Children aged 5-18 years (N = 1315) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were evaluated using questionnaires, anthropometric measurements, and serum levels of 25-hydroxyvitamin D [25(OH)D] and total and specific immunoglobulin E (IgE).

Results: The mean concentration of serum 25(OH)D was 20.4 ng/mL (SD: 7.1 ng/mL). Vitamin D deficiency (defined as serum 25(OH)D<20 ng/mL) was present in 670 subjects (51.0%), while vitamin D insufficiency (defined as serum 25(OH)D<30 ng/mL) was observed in 1187 subjects (90.3%). Older age (P<0.001), female gender (P<0.001), higher body mass index (P = 0.001), winter and spring seasons (compared to summer; P both<0.001), and passive smoking (P = 0.011) were independently associated with low serum 25(OH)D levels. After adjusting for potential confounders, serum 25(OH)D status had no association with asthma, rhinitis, eczema, atopy, or total serum IgE (all P>0.05).

Conclusions: Low serum 25(OH)D levels are remarkably common in this population sample of Asian children, suggesting that millions of children living in Taiwan may have suboptimal levels of vitamin D, which should be a matter of public health concern. Our results provides epidemiological evidence against the association of vitamin D status with various allergic diseases and atopy in Asian children.

Show MeSH
Related in: MedlinePlus