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Enhancement characteristics and impact on image quality of two gadolinium chelates at equimolar doses for time-resolved 3-Tesla MR-angiography of the calf station.

Hansmann J, Michaely HJ, Morelli JN, Luckscheiter A, Schoenberg SO, Attenberger UI - PLoS ONE (2014)

Bottom Line: Signal-to-noise-ratio (SNR), contrast-to-noise-ratio (CNR) and image quality were analysed and compared between the two groups.No significant difference in image quality was found except for the peroneal arteries (p = 0.006 and p = 0.04).Interreader agreement was excellent (kappa 0.87-0.93).

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Mannheim, Germany.

ABSTRACT

Purpose: To compare enhancement characteristics and image quality of two macrocyclic gadolinium chelates, gadoterate meglumine and gadobutrol, in low-dose, time-resolved MRA of the calf station.

Materials and methods: 100 consecutive patients with peripheral arterial disease (stages II-IV) were retrospectively analysed. Fifty patients were included in each group - 32 men and 18 women for gadobutrol (mean age 67 years) and 34 men, 16 women for gadoterate meglumine (mean age 64 years). 0.03 mmol/kg bw of either gadobutrol or gadoterate meglumine was injected. Gadobutrol was diluted 1 ∶ 1 with normal saline (0.9% NaCl) to provide similar injection volume and bolus geometry compared to the undiluted 0.5 M dose of gadoterate meglumine. Signal-to-noise-ratio (SNR), contrast-to-noise-ratio (CNR) and image quality were analysed and compared between the two groups.

Results: Mean SNR ranged from 83.0 ± 46.7 (peroneal artery) to 96.4 ± 64.5 (anterior tibial artery) for gadobutrol, and from 37.6 ± 13.8 (peroneal artery) to 45.3 ± 16.4 (anterior tibial artery) for the gadoterate meglumine group (p<0.0001). CNR values ranged from 30.1 ± 20.1 (peroneal artery) to 37.6 ± 26.0 (anterior tibial artery) for gadobutrol and from 14.9 ± 8.0 (peroneal artery) to 18.6 ± 16.4 (anterior tibial artery) for gadoterate meglumine (p<0.0001). No significant difference in image quality was found except for the peroneal arteries (p = 0.006 and p = 0.04). Interreader agreement was excellent (kappa 0.87-0.93).

Conclusion: The significantly better enhancement as assessed by SNR and CNR provided by gadobutrol compared to gadoterate meglumine does not translate into substantial differences in image quality in an equimolar, low-dose, time-resolved MRA protocol of the calves.

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Higher SNR and CNR in time resolved MR-Angiography does not translate into improved image quality.Gadobutrol was utilized as the contrast agent in a 80 year old female with SNR/CNR values of 93/65 for the anterior tibial artery, 125/101 for the posterior tibial artery and 90/62 for the peroneal artery. Gadoterate meglumine administered in a 61 year old female resulted in SNR/CNR values of 60/21 for the anterior tibial artery, 55/21 for the posterior tibial artery and 52/19 for the peroneal artery. Image quality was rated good to excellent by both readers in both cases.
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pone-0099079-g001: Higher SNR and CNR in time resolved MR-Angiography does not translate into improved image quality.Gadobutrol was utilized as the contrast agent in a 80 year old female with SNR/CNR values of 93/65 for the anterior tibial artery, 125/101 for the posterior tibial artery and 90/62 for the peroneal artery. Gadoterate meglumine administered in a 61 year old female resulted in SNR/CNR values of 60/21 for the anterior tibial artery, 55/21 for the posterior tibial artery and 52/19 for the peroneal artery. Image quality was rated good to excellent by both readers in both cases.

Mentions: For reader 1, qualitative assessments were possible for the gadobutrol scans in 91% (87/96) of cases for the anterior tibial artery, 81% (78/96) of cases for the posterior tibial artery, and 90% (86/96) of cases for the peroneal artery. For the gadoterate meglumine scans, these respective assessments were possible in 89% (85/96), (89%) 85/96, and 93% (89/96) of cases. For reader 2, qualitative assessments were possible for the gadobutrol scans in 91% (87/96) of cases for the anterior tibial artery, 80% (77/96) of cases for the posterior tibial artery, and 90% (86/96) of cases for the peroneal artery. For the gadoterate meglumine scans these respective assessments were possible in 90% (85/96), 90% (85/96), and 92% (88/96) of cases. Image quality ratings ranged from values of 1–4 for each reader. Median ratings of image quality are provided in Table 3. Statistically significant differences in image quality were observed between gadobutrol and gadoterate meglumine in the peroneal arteries for both readers. Kappa values demonstrated excellent interobserver agreement for all qualitative assessments (Table 3). An example of individual SNR and CNR values as well as the pertinent image quality ratings by both readers is provided in figure 1.


Enhancement characteristics and impact on image quality of two gadolinium chelates at equimolar doses for time-resolved 3-Tesla MR-angiography of the calf station.

Hansmann J, Michaely HJ, Morelli JN, Luckscheiter A, Schoenberg SO, Attenberger UI - PLoS ONE (2014)

Higher SNR and CNR in time resolved MR-Angiography does not translate into improved image quality.Gadobutrol was utilized as the contrast agent in a 80 year old female with SNR/CNR values of 93/65 for the anterior tibial artery, 125/101 for the posterior tibial artery and 90/62 for the peroneal artery. Gadoterate meglumine administered in a 61 year old female resulted in SNR/CNR values of 60/21 for the anterior tibial artery, 55/21 for the posterior tibial artery and 52/19 for the peroneal artery. Image quality was rated good to excellent by both readers in both cases.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043962&req=5

pone-0099079-g001: Higher SNR and CNR in time resolved MR-Angiography does not translate into improved image quality.Gadobutrol was utilized as the contrast agent in a 80 year old female with SNR/CNR values of 93/65 for the anterior tibial artery, 125/101 for the posterior tibial artery and 90/62 for the peroneal artery. Gadoterate meglumine administered in a 61 year old female resulted in SNR/CNR values of 60/21 for the anterior tibial artery, 55/21 for the posterior tibial artery and 52/19 for the peroneal artery. Image quality was rated good to excellent by both readers in both cases.
Mentions: For reader 1, qualitative assessments were possible for the gadobutrol scans in 91% (87/96) of cases for the anterior tibial artery, 81% (78/96) of cases for the posterior tibial artery, and 90% (86/96) of cases for the peroneal artery. For the gadoterate meglumine scans, these respective assessments were possible in 89% (85/96), (89%) 85/96, and 93% (89/96) of cases. For reader 2, qualitative assessments were possible for the gadobutrol scans in 91% (87/96) of cases for the anterior tibial artery, 80% (77/96) of cases for the posterior tibial artery, and 90% (86/96) of cases for the peroneal artery. For the gadoterate meglumine scans these respective assessments were possible in 90% (85/96), 90% (85/96), and 92% (88/96) of cases. Image quality ratings ranged from values of 1–4 for each reader. Median ratings of image quality are provided in Table 3. Statistically significant differences in image quality were observed between gadobutrol and gadoterate meglumine in the peroneal arteries for both readers. Kappa values demonstrated excellent interobserver agreement for all qualitative assessments (Table 3). An example of individual SNR and CNR values as well as the pertinent image quality ratings by both readers is provided in figure 1.

Bottom Line: Signal-to-noise-ratio (SNR), contrast-to-noise-ratio (CNR) and image quality were analysed and compared between the two groups.No significant difference in image quality was found except for the peroneal arteries (p = 0.006 and p = 0.04).Interreader agreement was excellent (kappa 0.87-0.93).

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Mannheim, Germany.

ABSTRACT

Purpose: To compare enhancement characteristics and image quality of two macrocyclic gadolinium chelates, gadoterate meglumine and gadobutrol, in low-dose, time-resolved MRA of the calf station.

Materials and methods: 100 consecutive patients with peripheral arterial disease (stages II-IV) were retrospectively analysed. Fifty patients were included in each group - 32 men and 18 women for gadobutrol (mean age 67 years) and 34 men, 16 women for gadoterate meglumine (mean age 64 years). 0.03 mmol/kg bw of either gadobutrol or gadoterate meglumine was injected. Gadobutrol was diluted 1 ∶ 1 with normal saline (0.9% NaCl) to provide similar injection volume and bolus geometry compared to the undiluted 0.5 M dose of gadoterate meglumine. Signal-to-noise-ratio (SNR), contrast-to-noise-ratio (CNR) and image quality were analysed and compared between the two groups.

Results: Mean SNR ranged from 83.0 ± 46.7 (peroneal artery) to 96.4 ± 64.5 (anterior tibial artery) for gadobutrol, and from 37.6 ± 13.8 (peroneal artery) to 45.3 ± 16.4 (anterior tibial artery) for the gadoterate meglumine group (p<0.0001). CNR values ranged from 30.1 ± 20.1 (peroneal artery) to 37.6 ± 26.0 (anterior tibial artery) for gadobutrol and from 14.9 ± 8.0 (peroneal artery) to 18.6 ± 16.4 (anterior tibial artery) for gadoterate meglumine (p<0.0001). No significant difference in image quality was found except for the peroneal arteries (p = 0.006 and p = 0.04). Interreader agreement was excellent (kappa 0.87-0.93).

Conclusion: The significantly better enhancement as assessed by SNR and CNR provided by gadobutrol compared to gadoterate meglumine does not translate into substantial differences in image quality in an equimolar, low-dose, time-resolved MRA protocol of the calves.

Show MeSH
Related in: MedlinePlus