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Native T1 mapping correlates with severity of microvascular dysfunction measured by coronary flow reserve (CFR) in acute myocardial infarction

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Native T1 mapping cardiac magnetic resonance (CMR) imaging allows for quantitative assessment of myocardial oedema following acute myocardial infarction (MI)... The relation between increasingly higher native T1 values and the underlying severity of microvascular damage due to ischemic insult is not known.We hypothesise that T1 values measured in areas of injured myocardium, correlate to invasive measurements of CFR and microvascular dysfunction... Matching short axis slices with full left ventricle (LV) coverage were acquired using functional steady-state free precession (SSFP) imaging, native T1 mapping, oedema T2W imaging and late gadolinium enhancement (LGE)... For the comparisons among acute T1-mapping, T2W and LGE, we excluded apical slices due to partial volume effects and slices with off-resonance artifacts... Global and segmental injured fractions by LGE and oedema were assessed; segmental T1 values were calculated in the injured myocardial segments with an injured fraction of at least 50% as determined by oedema and/or LGE... Fourteen underwent CMR and CFR at 24 hrs... The EF was 53 ± 10%, with a LV damaged fraction measured by oedema and LGE of 37 ± 15% and 30 ± 13%... The average T1 values in the injured areas were 1295 ± 61 msec (mean ± SD, range 1159-1388 msec) (normal values = 1196 ± 56 msec)... There was a significant correlation (r = -0.7, p < 0.01) between the 24 hrs CFR and the average T1 value in the affected myocardium (Figure 1)... Increasingly higher native T1 values correlate with the severity of myocardial injury assessed by invasive CFR at 24 hours post STEMI.

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Mentions: Out of the recruited patients, 6 were excluded due to microvascular obstruction on LGE. Fourteen underwent CMR and CFR at 24 hrs. The EF was 53 ± 10%, with a LV damaged fraction measured by oedema and LGE of 37 ± 15% and 30 ± 13%. The average T1 values in the injured areas were 1295 ± 61 msec (mean ± SD, range 1159-1388 msec) (normal values = 1196 ± 56 msec). There was a significant correlation (r = -0.7, p < 0.01) between the 24 hrs CFR and the average T1 value in the affected myocardium (Figure 1).


Native T1 mapping correlates with severity of microvascular dysfunction measured by coronary flow reserve (CFR) in acute myocardial infarction
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4043940&req=5

Mentions: Out of the recruited patients, 6 were excluded due to microvascular obstruction on LGE. Fourteen underwent CMR and CFR at 24 hrs. The EF was 53 ± 10%, with a LV damaged fraction measured by oedema and LGE of 37 ± 15% and 30 ± 13%. The average T1 values in the injured areas were 1295 ± 61 msec (mean ± SD, range 1159-1388 msec) (normal values = 1196 ± 56 msec). There was a significant correlation (r = -0.7, p < 0.01) between the 24 hrs CFR and the average T1 value in the affected myocardium (Figure 1).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Native T1 mapping cardiac magnetic resonance (CMR) imaging allows for quantitative assessment of myocardial oedema following acute myocardial infarction (MI)... The relation between increasingly higher native T1 values and the underlying severity of microvascular damage due to ischemic insult is not known.We hypothesise that T1 values measured in areas of injured myocardium, correlate to invasive measurements of CFR and microvascular dysfunction... Matching short axis slices with full left ventricle (LV) coverage were acquired using functional steady-state free precession (SSFP) imaging, native T1 mapping, oedema T2W imaging and late gadolinium enhancement (LGE)... For the comparisons among acute T1-mapping, T2W and LGE, we excluded apical slices due to partial volume effects and slices with off-resonance artifacts... Global and segmental injured fractions by LGE and oedema were assessed; segmental T1 values were calculated in the injured myocardial segments with an injured fraction of at least 50% as determined by oedema and/or LGE... Fourteen underwent CMR and CFR at 24 hrs... The EF was 53 ± 10%, with a LV damaged fraction measured by oedema and LGE of 37 ± 15% and 30 ± 13%... The average T1 values in the injured areas were 1295 ± 61 msec (mean ± SD, range 1159-1388 msec) (normal values = 1196 ± 56 msec)... There was a significant correlation (r = -0.7, p < 0.01) between the 24 hrs CFR and the average T1 value in the affected myocardium (Figure 1)... Increasingly higher native T1 values correlate with the severity of myocardial injury assessed by invasive CFR at 24 hours post STEMI.

No MeSH data available.