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Time series analysis of in vivo cardiac MRI-PET image fusion of the human amniotic mesenchymal stem cell (hAMSC) engraftment

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This study developed a system to monitor intensity changes in the cardiac PET-MRI images of transplanted stem cells in vivo... An ROI around the engrafted stem cells on MEMRI was copied to the same location on PET-CT longitudinally and average intensity was sampled at each time point... A fused PET-MEMRI and PET-DEMRI image, which displayed the two signals in a single image, was generated... The mean normalized ROI intensities across days 0, 7, and 45 were 22.00, 59.37, and 64.37 for MEMRI (Figure 1) and 3263.00, 7733.719, and 3664.310 for PET... The engrafted hAMSCs demonstrate significant manganese and radiotracer uptake to generate their respective signals indicative of cell engraftment... The increased MEMRI signal volume over time represented cell proliferation... The in vivo PET-MRI fusion validated the visual correlation of cell engraftment MEMRI signal and of longitudinal cell proliferation (Figure 2)... This study developed a system that monitors the engraftment of the transplanted stem cells in vivo, employing 2 imaging modalities... The fused PET-MRI images enable high spatial and temporal resolution of MRI while maintaining the high signal sensitivity of PET, demonstrating successful engraftment and proliferation of the stem cells.

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Average non-normalized signal intensity over an ROI was measured across post stem cell engraftment day 0 (left), 7, (center), 45 (right).
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Figure 1: Average non-normalized signal intensity over an ROI was measured across post stem cell engraftment day 0 (left), 7, (center), 45 (right).

Mentions: A fused PET-MEMRI and PET-DEMRI image, which displayed the two signals in a single image, was generated. The mean normalized ROI intensities across days 0, 7, and 45 were 22.00, 59.37, and 64.37 for MEMRI (Figure 1) and 3263.00, 7733.719, and 3664.310 for PET.


Time series analysis of in vivo cardiac MRI-PET image fusion of the human amniotic mesenchymal stem cell (hAMSC) engraftment
Average non-normalized signal intensity over an ROI was measured across post stem cell engraftment day 0 (left), 7, (center), 45 (right).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4043906&req=5

Figure 1: Average non-normalized signal intensity over an ROI was measured across post stem cell engraftment day 0 (left), 7, (center), 45 (right).
Mentions: A fused PET-MEMRI and PET-DEMRI image, which displayed the two signals in a single image, was generated. The mean normalized ROI intensities across days 0, 7, and 45 were 22.00, 59.37, and 64.37 for MEMRI (Figure 1) and 3263.00, 7733.719, and 3664.310 for PET.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

This study developed a system to monitor intensity changes in the cardiac PET-MRI images of transplanted stem cells in vivo... An ROI around the engrafted stem cells on MEMRI was copied to the same location on PET-CT longitudinally and average intensity was sampled at each time point... A fused PET-MEMRI and PET-DEMRI image, which displayed the two signals in a single image, was generated... The mean normalized ROI intensities across days 0, 7, and 45 were 22.00, 59.37, and 64.37 for MEMRI (Figure 1) and 3263.00, 7733.719, and 3664.310 for PET... The engrafted hAMSCs demonstrate significant manganese and radiotracer uptake to generate their respective signals indicative of cell engraftment... The increased MEMRI signal volume over time represented cell proliferation... The in vivo PET-MRI fusion validated the visual correlation of cell engraftment MEMRI signal and of longitudinal cell proliferation (Figure 2)... This study developed a system that monitors the engraftment of the transplanted stem cells in vivo, employing 2 imaging modalities... The fused PET-MRI images enable high spatial and temporal resolution of MRI while maintaining the high signal sensitivity of PET, demonstrating successful engraftment and proliferation of the stem cells.

No MeSH data available.