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Comparison of myocardial T1 mapping techniques at 1.5T to detect interstitial fibrosis in patients with orthotopic cardiac transplant

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This inflammatory reaction is followed by both replacement fibrosis and interstitial fibrosis which in the long term can impair diastolic and systolic ventricular (LV) function... In HTx native pre -contrast T1 was 1007 ± 75 vs (N) 957 ± 44 msec p < 0.001, T1 post-contrast was 400 ± 47 msec vs (N) 455 ± 35 msec p < 0.001, ECV was 39.4 ± 4% vs 33.3 ± 3%(N) p < 0.001... ECV had the best Sensitivity(Se) 84% and Specificity(Sp) 78% at ROC analysis (cut-off 35.4%), for identifying HTx patients from N (Figure 1A)... Whereas within Htx population T1 precontrast was more accurate to identify previous systemic CMV infection Se 77% and Sp 75% (cut-off 993 msec) (Figure 1B)... T1 Pre was significantly higher in HTx with left ventricular hypertrophy P = 0.02... ECV, but not T1 pre or post, was inversely correlated to IVRT (msec) at echo p < 0.003... HTx patients with no active rejection show a significant increase of ECV and T1 relaxation time, an indication of increased interstitial fibrosis... In this population ECV seems to better identify deposition of collagen, whereas non contrast T1 mapping is also influenced by the presence of tissue inflammation... These preliminary findings need further confirmation in large scale studies that will assess both the diagnostic and prognostic values of T1 mapping derived parameters

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Mentions: Systolic function was similar in both groups HTx 64 ± 11 vs N 68 ± 5 p = 0.32, LV Mass Index was slightly higher in HTx 75 ± 14 vs 69 ± 16 N p = 0.2. In HTx native pre -contrast T1 was 1007 ± 75 vs (N) 957 ± 44 msec p < 0.001, T1 post-contrast was 400 ± 47 msec vs (N) 455 ± 35 msec p < 0.001, ECV was 39.4 ± 4% vs 33.3 ± 3%(N) p < 0.001. ECV had the best Sensitivity(Se) 84% and Specificity(Sp) 78% at ROC analysis (cut-off 35.4%), for identifying HTx patients from N (Figure 1A). Whereas within Htx population T1 precontrast was more accurate to identify previous systemic CMV infection Se 77% and Sp 75% (cut-off 993 msec) (Figure 1B). T1 Pre was significantly higher in HTx with left ventricular hypertrophy P = 0.02. ECV, but not T1 pre or post, was inversely correlated to IVRT (msec) at echo p < 0.003.


Comparison of myocardial T1 mapping techniques at 1.5T to detect interstitial fibrosis in patients with orthotopic cardiac transplant
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4043824&req=5

Mentions: Systolic function was similar in both groups HTx 64 ± 11 vs N 68 ± 5 p = 0.32, LV Mass Index was slightly higher in HTx 75 ± 14 vs 69 ± 16 N p = 0.2. In HTx native pre -contrast T1 was 1007 ± 75 vs (N) 957 ± 44 msec p < 0.001, T1 post-contrast was 400 ± 47 msec vs (N) 455 ± 35 msec p < 0.001, ECV was 39.4 ± 4% vs 33.3 ± 3%(N) p < 0.001. ECV had the best Sensitivity(Se) 84% and Specificity(Sp) 78% at ROC analysis (cut-off 35.4%), for identifying HTx patients from N (Figure 1A). Whereas within Htx population T1 precontrast was more accurate to identify previous systemic CMV infection Se 77% and Sp 75% (cut-off 993 msec) (Figure 1B). T1 Pre was significantly higher in HTx with left ventricular hypertrophy P = 0.02. ECV, but not T1 pre or post, was inversely correlated to IVRT (msec) at echo p < 0.003.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

This inflammatory reaction is followed by both replacement fibrosis and interstitial fibrosis which in the long term can impair diastolic and systolic ventricular (LV) function... In HTx native pre -contrast T1 was 1007 ± 75 vs (N) 957 ± 44 msec p < 0.001, T1 post-contrast was 400 ± 47 msec vs (N) 455 ± 35 msec p < 0.001, ECV was 39.4 ± 4% vs 33.3 ± 3%(N) p < 0.001... ECV had the best Sensitivity(Se) 84% and Specificity(Sp) 78% at ROC analysis (cut-off 35.4%), for identifying HTx patients from N (Figure 1A)... Whereas within Htx population T1 precontrast was more accurate to identify previous systemic CMV infection Se 77% and Sp 75% (cut-off 993 msec) (Figure 1B)... T1 Pre was significantly higher in HTx with left ventricular hypertrophy P = 0.02... ECV, but not T1 pre or post, was inversely correlated to IVRT (msec) at echo p < 0.003... HTx patients with no active rejection show a significant increase of ECV and T1 relaxation time, an indication of increased interstitial fibrosis... In this population ECV seems to better identify deposition of collagen, whereas non contrast T1 mapping is also influenced by the presence of tissue inflammation... These preliminary findings need further confirmation in large scale studies that will assess both the diagnostic and prognostic values of T1 mapping derived parameters

No MeSH data available.