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Role of argon laser as an adjunctive therapy for treatment of resistant infected corneal ulcers.

Khater MM, Selima AA, El-Shorbagy MS - Clin Ophthalmol (2014)

Bottom Line: During the first 4 weeks after laser treatment, all patients showed complete healing of the epithelial defect and resolution of stromal infiltration with no adverse effects.Argon laser phototherapy is useful as an adjunctive treatment for resistant infected corneal ulcers.More cases are needed to get more reliable results and to confirm our findings.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Tanta University, Tanta, Egypt.

ABSTRACT

Purpose: To evaluate the role of argon laser as an adjunctive therapy in ten patients with resistant infected corneal ulcers with or without hypopyon.

Methods: The study included 20 patients, split into two groups of ten, with resistant infected corneal ulcers with or without hypopyon. One group was considered as the control group and treated with local and systemic specific antimicrobial drugs guided with culture and sensitivity tests. The other group started with the same specific therapy as the control group for 1 week with no obvious improvement and then was further treated with argon laser. The ten patients in the control group included five cases of fungal ulcers, three mixed (fungal and bacterial) ulcers, and two viral ulcers. The ten patients in the other group included three cases of fungal ulcers, three mixed (fungal and viral) ulcers, three viral ulcers, and one bacterial ulcer as proven with microbial culture and sensitivity tests. Eight cases of the control group and seven cases of the other group were associated with hypopyon. Before laser treatment, a drop of benoxinate hydrochloride 0.4% and a single drop of fluorescein sodium 0.25% were instilled. Argon laser irradiation of the affected cornea was performed using an argon 532 nm wavelength (Carl Zeiss LSL 532s AG; Carl Zeiss Meditec AG, Jena, Germany). A spot size of 500 μm, pulse duration of 0.2 seconds, and power of 900 mW were used. All cases were followed up for 3 months after healing was achieved.

Results: During the first 4 weeks after laser treatment, all patients showed complete healing of the epithelial defect and resolution of stromal infiltration with no adverse effects. In the control group, four cases needed an amniotic membrane graft due to thinning and the other six cases were healed in a duration that ranged from 3 to 7 weeks.

Conclusion: Argon laser phototherapy is useful as an adjunctive treatment for resistant infected corneal ulcers. More cases are needed to get more reliable results and to confirm our findings.

No MeSH data available.


Related in: MedlinePlus

Visual acuity improvement in the laser and control groups after healing.
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f5-opth-8-1025: Visual acuity improvement in the laser and control groups after healing.

Mentions: As regards visual acuity improvement, in the laser treatment group, three cases showed improvement with a gain of two or more lines, three cases with a gain of one line, and four cases showed no improvement; in the control group, three cases showed a gain of one line and seven cases showed no improvement; with a significant P-value when comparing the two groups (Table 2, Figure 5).


Role of argon laser as an adjunctive therapy for treatment of resistant infected corneal ulcers.

Khater MM, Selima AA, El-Shorbagy MS - Clin Ophthalmol (2014)

Visual acuity improvement in the laser and control groups after healing.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043817&req=5

f5-opth-8-1025: Visual acuity improvement in the laser and control groups after healing.
Mentions: As regards visual acuity improvement, in the laser treatment group, three cases showed improvement with a gain of two or more lines, three cases with a gain of one line, and four cases showed no improvement; in the control group, three cases showed a gain of one line and seven cases showed no improvement; with a significant P-value when comparing the two groups (Table 2, Figure 5).

Bottom Line: During the first 4 weeks after laser treatment, all patients showed complete healing of the epithelial defect and resolution of stromal infiltration with no adverse effects.Argon laser phototherapy is useful as an adjunctive treatment for resistant infected corneal ulcers.More cases are needed to get more reliable results and to confirm our findings.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Tanta University, Tanta, Egypt.

ABSTRACT

Purpose: To evaluate the role of argon laser as an adjunctive therapy in ten patients with resistant infected corneal ulcers with or without hypopyon.

Methods: The study included 20 patients, split into two groups of ten, with resistant infected corneal ulcers with or without hypopyon. One group was considered as the control group and treated with local and systemic specific antimicrobial drugs guided with culture and sensitivity tests. The other group started with the same specific therapy as the control group for 1 week with no obvious improvement and then was further treated with argon laser. The ten patients in the control group included five cases of fungal ulcers, three mixed (fungal and bacterial) ulcers, and two viral ulcers. The ten patients in the other group included three cases of fungal ulcers, three mixed (fungal and viral) ulcers, three viral ulcers, and one bacterial ulcer as proven with microbial culture and sensitivity tests. Eight cases of the control group and seven cases of the other group were associated with hypopyon. Before laser treatment, a drop of benoxinate hydrochloride 0.4% and a single drop of fluorescein sodium 0.25% were instilled. Argon laser irradiation of the affected cornea was performed using an argon 532 nm wavelength (Carl Zeiss LSL 532s AG; Carl Zeiss Meditec AG, Jena, Germany). A spot size of 500 μm, pulse duration of 0.2 seconds, and power of 900 mW were used. All cases were followed up for 3 months after healing was achieved.

Results: During the first 4 weeks after laser treatment, all patients showed complete healing of the epithelial defect and resolution of stromal infiltration with no adverse effects. In the control group, four cases needed an amniotic membrane graft due to thinning and the other six cases were healed in a duration that ranged from 3 to 7 weeks.

Conclusion: Argon laser phototherapy is useful as an adjunctive treatment for resistant infected corneal ulcers. More cases are needed to get more reliable results and to confirm our findings.

No MeSH data available.


Related in: MedlinePlus