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Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy.

Xu L, Lee BS, Asif S, Kraemer P, Inki P - Int J Womens Health (2014)

Bottom Line: This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05).The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time.The improvement was greater with the LNG-IUS, compared with CMTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB).

Patients and methods: A total of 647 patients diagnosed with HMB were recruited to this non-interventional study from the eight participating countries in Asia. Patient satisfaction was recorded at the last visit (at 12 months or premature discontinuation). At each visit (at 3, 6, and 12 months), patients completed the menorrhagia multi-attribute scale (MMAS) to assess HRQoL.

Results: A total of 83.5% of patients on the LNG-IUS were "very satisfied" or at least "satisfied" with the therapeutic effect of HMB treatment, compared with 59.2% of patients with CMTs (P<0.05). The mean (± standard deviation) MMAS score increased from 41.4±24.5 to 87.7±21.4 in the LNG-IUS arm, and from 44.1±24.9 to 73.1±25.3 in the CMTs arm. This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05). The improvement in HRQoL in both treatment groups correlated with the body mass index of the patient, with larger improvement obtained in women with a higher body mass index.

Conclusion: The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time. The improvement was greater with the LNG-IUS, compared with CMTs.

No MeSH data available.


Related in: MedlinePlus

Menorrhagia multi-attribute scale scores at baseline and 12-months follow-up (mean ± SD) stratified by BMI, LNG-IUS versus CMT.Notes:P<0.0032 for between treatment difference. P<0.0001 for difference between BMI groups.Abbreviations: BMI, body mass index; CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system; MMAS, menorrhagia multi-attribute scale; SD, standard deviation.
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f4-ijwh-6-547: Menorrhagia multi-attribute scale scores at baseline and 12-months follow-up (mean ± SD) stratified by BMI, LNG-IUS versus CMT.Notes:P<0.0032 for between treatment difference. P<0.0001 for difference between BMI groups.Abbreviations: BMI, body mass index; CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system; MMAS, menorrhagia multi-attribute scale; SD, standard deviation.

Mentions: The baseline scores of the patients in different BMI categories were fairly similar for both treatment groups, except that the score tended to be lower for patients with a BMI ≥30 kg/m2 compared with the other BMI groups (Figure 4). Both the treatment modality group (P<0.05) and the BMI group (P<0.05) had a significant effect on the change in the MMAS score from baseline to 12 months. The LNG-IUS was superior to CMTs and the greatest improvement was seen in those with a BMI ≥30 kg/m2 (Figure 4). With regard to the different age groups and treatment modalities, there was a significant change in the MMAS score from baseline to 12 months (P<0.05). There was an overall difference in the level of the MMAS score for the different age groups, but age group had no significant effect on the change in the MMAS score from baseline to 12 months (Figure 5).


Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy.

Xu L, Lee BS, Asif S, Kraemer P, Inki P - Int J Womens Health (2014)

Menorrhagia multi-attribute scale scores at baseline and 12-months follow-up (mean ± SD) stratified by BMI, LNG-IUS versus CMT.Notes:P<0.0032 for between treatment difference. P<0.0001 for difference between BMI groups.Abbreviations: BMI, body mass index; CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system; MMAS, menorrhagia multi-attribute scale; SD, standard deviation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043813&req=5

f4-ijwh-6-547: Menorrhagia multi-attribute scale scores at baseline and 12-months follow-up (mean ± SD) stratified by BMI, LNG-IUS versus CMT.Notes:P<0.0032 for between treatment difference. P<0.0001 for difference between BMI groups.Abbreviations: BMI, body mass index; CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system; MMAS, menorrhagia multi-attribute scale; SD, standard deviation.
Mentions: The baseline scores of the patients in different BMI categories were fairly similar for both treatment groups, except that the score tended to be lower for patients with a BMI ≥30 kg/m2 compared with the other BMI groups (Figure 4). Both the treatment modality group (P<0.05) and the BMI group (P<0.05) had a significant effect on the change in the MMAS score from baseline to 12 months. The LNG-IUS was superior to CMTs and the greatest improvement was seen in those with a BMI ≥30 kg/m2 (Figure 4). With regard to the different age groups and treatment modalities, there was a significant change in the MMAS score from baseline to 12 months (P<0.05). There was an overall difference in the level of the MMAS score for the different age groups, but age group had no significant effect on the change in the MMAS score from baseline to 12 months (Figure 5).

Bottom Line: This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05).The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time.The improvement was greater with the LNG-IUS, compared with CMTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB).

Patients and methods: A total of 647 patients diagnosed with HMB were recruited to this non-interventional study from the eight participating countries in Asia. Patient satisfaction was recorded at the last visit (at 12 months or premature discontinuation). At each visit (at 3, 6, and 12 months), patients completed the menorrhagia multi-attribute scale (MMAS) to assess HRQoL.

Results: A total of 83.5% of patients on the LNG-IUS were "very satisfied" or at least "satisfied" with the therapeutic effect of HMB treatment, compared with 59.2% of patients with CMTs (P<0.05). The mean (± standard deviation) MMAS score increased from 41.4±24.5 to 87.7±21.4 in the LNG-IUS arm, and from 44.1±24.9 to 73.1±25.3 in the CMTs arm. This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05). The improvement in HRQoL in both treatment groups correlated with the body mass index of the patient, with larger improvement obtained in women with a higher body mass index.

Conclusion: The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time. The improvement was greater with the LNG-IUS, compared with CMTs.

No MeSH data available.


Related in: MedlinePlus