Limits...
Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy.

Xu L, Lee BS, Asif S, Kraemer P, Inki P - Int J Womens Health (2014)

Bottom Line: This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05).The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time.The improvement was greater with the LNG-IUS, compared with CMTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB).

Patients and methods: A total of 647 patients diagnosed with HMB were recruited to this non-interventional study from the eight participating countries in Asia. Patient satisfaction was recorded at the last visit (at 12 months or premature discontinuation). At each visit (at 3, 6, and 12 months), patients completed the menorrhagia multi-attribute scale (MMAS) to assess HRQoL.

Results: A total of 83.5% of patients on the LNG-IUS were "very satisfied" or at least "satisfied" with the therapeutic effect of HMB treatment, compared with 59.2% of patients with CMTs (P<0.05). The mean (± standard deviation) MMAS score increased from 41.4±24.5 to 87.7±21.4 in the LNG-IUS arm, and from 44.1±24.9 to 73.1±25.3 in the CMTs arm. This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05). The improvement in HRQoL in both treatment groups correlated with the body mass index of the patient, with larger improvement obtained in women with a higher body mass index.

Conclusion: The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time. The improvement was greater with the LNG-IUS, compared with CMTs.

No MeSH data available.


Related in: MedlinePlus

Menorrhagia multi-attribute scale scores (mean ± SD) in the two treatment groups, LNG-IUS versus CMT.Note: In both groups, the increase of MMAS was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system; MMAS, menorrhagia multi-attribute scale; SD, standard deviation.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4043813&req=5

f3-ijwh-6-547: Menorrhagia multi-attribute scale scores (mean ± SD) in the two treatment groups, LNG-IUS versus CMT.Note: In both groups, the increase of MMAS was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system; MMAS, menorrhagia multi-attribute scale; SD, standard deviation.

Mentions: The majority of the patients (74.1% and 62.2% LNG-IUS and CMTs, respectively) completed the MMAS questionnaires at all four visits, while 15% of the overall population (14.9% and 15.6% LNG-IUS and CMTs, respectively) completed three questionnaires, 7.3% (5.9% and 11.9% LNG-IUS and CMTs, respectively) completed two questionnaires, and 3.0% (2.1% and 5.9% LNG-IUS and CMTs, respectively) completed only one questionnaire. No questionnaires were returned by 3.1% (18/572) women: 12 in the LNG-IUS and six in the CMTs group. The baseline mean (± standard deviation) MMAS score was 41.4±24.5 in the LNG-IUS arm and 44.1±24.9 in the CMTs arm. In both treatment groups, the MMAS score significantly increased over the study period (P<0.05). At 12 months, the mean increase in the MMAS score from baseline to 12 months was 51.1 in the LNG-IUS group and 29.9 in the CMTs group (Figure 3), and this difference was statistically significant (P<0.05).


Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy.

Xu L, Lee BS, Asif S, Kraemer P, Inki P - Int J Womens Health (2014)

Menorrhagia multi-attribute scale scores (mean ± SD) in the two treatment groups, LNG-IUS versus CMT.Note: In both groups, the increase of MMAS was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system; MMAS, menorrhagia multi-attribute scale; SD, standard deviation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043813&req=5

f3-ijwh-6-547: Menorrhagia multi-attribute scale scores (mean ± SD) in the two treatment groups, LNG-IUS versus CMT.Note: In both groups, the increase of MMAS was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system; MMAS, menorrhagia multi-attribute scale; SD, standard deviation.
Mentions: The majority of the patients (74.1% and 62.2% LNG-IUS and CMTs, respectively) completed the MMAS questionnaires at all four visits, while 15% of the overall population (14.9% and 15.6% LNG-IUS and CMTs, respectively) completed three questionnaires, 7.3% (5.9% and 11.9% LNG-IUS and CMTs, respectively) completed two questionnaires, and 3.0% (2.1% and 5.9% LNG-IUS and CMTs, respectively) completed only one questionnaire. No questionnaires were returned by 3.1% (18/572) women: 12 in the LNG-IUS and six in the CMTs group. The baseline mean (± standard deviation) MMAS score was 41.4±24.5 in the LNG-IUS arm and 44.1±24.9 in the CMTs arm. In both treatment groups, the MMAS score significantly increased over the study period (P<0.05). At 12 months, the mean increase in the MMAS score from baseline to 12 months was 51.1 in the LNG-IUS group and 29.9 in the CMTs group (Figure 3), and this difference was statistically significant (P<0.05).

Bottom Line: This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05).The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time.The improvement was greater with the LNG-IUS, compared with CMTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB).

Patients and methods: A total of 647 patients diagnosed with HMB were recruited to this non-interventional study from the eight participating countries in Asia. Patient satisfaction was recorded at the last visit (at 12 months or premature discontinuation). At each visit (at 3, 6, and 12 months), patients completed the menorrhagia multi-attribute scale (MMAS) to assess HRQoL.

Results: A total of 83.5% of patients on the LNG-IUS were "very satisfied" or at least "satisfied" with the therapeutic effect of HMB treatment, compared with 59.2% of patients with CMTs (P<0.05). The mean (± standard deviation) MMAS score increased from 41.4±24.5 to 87.7±21.4 in the LNG-IUS arm, and from 44.1±24.9 to 73.1±25.3 in the CMTs arm. This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05). The improvement in HRQoL in both treatment groups correlated with the body mass index of the patient, with larger improvement obtained in women with a higher body mass index.

Conclusion: The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time. The improvement was greater with the LNG-IUS, compared with CMTs.

No MeSH data available.


Related in: MedlinePlus