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Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy.

Xu L, Lee BS, Asif S, Kraemer P, Inki P - Int J Womens Health (2014)

Bottom Line: This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05).The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time.The improvement was greater with the LNG-IUS, compared with CMTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB).

Patients and methods: A total of 647 patients diagnosed with HMB were recruited to this non-interventional study from the eight participating countries in Asia. Patient satisfaction was recorded at the last visit (at 12 months or premature discontinuation). At each visit (at 3, 6, and 12 months), patients completed the menorrhagia multi-attribute scale (MMAS) to assess HRQoL.

Results: A total of 83.5% of patients on the LNG-IUS were "very satisfied" or at least "satisfied" with the therapeutic effect of HMB treatment, compared with 59.2% of patients with CMTs (P<0.05). The mean (± standard deviation) MMAS score increased from 41.4±24.5 to 87.7±21.4 in the LNG-IUS arm, and from 44.1±24.9 to 73.1±25.3 in the CMTs arm. This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05). The improvement in HRQoL in both treatment groups correlated with the body mass index of the patient, with larger improvement obtained in women with a higher body mass index.

Conclusion: The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time. The improvement was greater with the LNG-IUS, compared with CMTs.

No MeSH data available.


Related in: MedlinePlus

Treatment satisfaction with LNG-IUS or CMT, as compared to previous treatment.Notes: The questionnaire was filled out by all women. Those without a history of previous treatment are included in the “Missing” category. The difference between groups was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system.
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f2-ijwh-6-547: Treatment satisfaction with LNG-IUS or CMT, as compared to previous treatment.Notes: The questionnaire was filled out by all women. Those without a history of previous treatment are included in the “Missing” category. The difference between groups was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system.

Mentions: Previous HMB treatment, that was applied for at least 2 months, was recorded for 156/437 LNG-IUS patients (35.7%) and for 60/135 patients with CMTs (44.4%, not significant between treatment groups). Figure 2 displays the comparison of current therapy to previous therapy (women without previous therapy are included in the “missing” category). In the LNG-IUS group, more than one-third of the patients reported their current therapy as “much better” and more than 25% as “better” than previous therapy, while approximately 6% reported it to be “the same” and only 2% reported it as “worse”. In the CMTs group, <10% of patients on CMTs rated their current treatment to be “much better” than previous therapy, and approximately 30% reported their current treatment to have “better” efficacy than their previous treatment (Figure 2). The difference between groups was statistically significant (P<0.05, post-hoc Wilcoxon rank sum test).


Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy.

Xu L, Lee BS, Asif S, Kraemer P, Inki P - Int J Womens Health (2014)

Treatment satisfaction with LNG-IUS or CMT, as compared to previous treatment.Notes: The questionnaire was filled out by all women. Those without a history of previous treatment are included in the “Missing” category. The difference between groups was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043813&req=5

f2-ijwh-6-547: Treatment satisfaction with LNG-IUS or CMT, as compared to previous treatment.Notes: The questionnaire was filled out by all women. Those without a history of previous treatment are included in the “Missing” category. The difference between groups was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system.
Mentions: Previous HMB treatment, that was applied for at least 2 months, was recorded for 156/437 LNG-IUS patients (35.7%) and for 60/135 patients with CMTs (44.4%, not significant between treatment groups). Figure 2 displays the comparison of current therapy to previous therapy (women without previous therapy are included in the “missing” category). In the LNG-IUS group, more than one-third of the patients reported their current therapy as “much better” and more than 25% as “better” than previous therapy, while approximately 6% reported it to be “the same” and only 2% reported it as “worse”. In the CMTs group, <10% of patients on CMTs rated their current treatment to be “much better” than previous therapy, and approximately 30% reported their current treatment to have “better” efficacy than their previous treatment (Figure 2). The difference between groups was statistically significant (P<0.05, post-hoc Wilcoxon rank sum test).

Bottom Line: This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05).The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time.The improvement was greater with the LNG-IUS, compared with CMTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB).

Patients and methods: A total of 647 patients diagnosed with HMB were recruited to this non-interventional study from the eight participating countries in Asia. Patient satisfaction was recorded at the last visit (at 12 months or premature discontinuation). At each visit (at 3, 6, and 12 months), patients completed the menorrhagia multi-attribute scale (MMAS) to assess HRQoL.

Results: A total of 83.5% of patients on the LNG-IUS were "very satisfied" or at least "satisfied" with the therapeutic effect of HMB treatment, compared with 59.2% of patients with CMTs (P<0.05). The mean (± standard deviation) MMAS score increased from 41.4±24.5 to 87.7±21.4 in the LNG-IUS arm, and from 44.1±24.9 to 73.1±25.3 in the CMTs arm. This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05). The improvement in HRQoL in both treatment groups correlated with the body mass index of the patient, with larger improvement obtained in women with a higher body mass index.

Conclusion: The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time. The improvement was greater with the LNG-IUS, compared with CMTs.

No MeSH data available.


Related in: MedlinePlus