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Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy.

Xu L, Lee BS, Asif S, Kraemer P, Inki P - Int J Womens Health (2014)

Bottom Line: This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05).The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time.The improvement was greater with the LNG-IUS, compared with CMTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB).

Patients and methods: A total of 647 patients diagnosed with HMB were recruited to this non-interventional study from the eight participating countries in Asia. Patient satisfaction was recorded at the last visit (at 12 months or premature discontinuation). At each visit (at 3, 6, and 12 months), patients completed the menorrhagia multi-attribute scale (MMAS) to assess HRQoL.

Results: A total of 83.5% of patients on the LNG-IUS were "very satisfied" or at least "satisfied" with the therapeutic effect of HMB treatment, compared with 59.2% of patients with CMTs (P<0.05). The mean (± standard deviation) MMAS score increased from 41.4±24.5 to 87.7±21.4 in the LNG-IUS arm, and from 44.1±24.9 to 73.1±25.3 in the CMTs arm. This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05). The improvement in HRQoL in both treatment groups correlated with the body mass index of the patient, with larger improvement obtained in women with a higher body mass index.

Conclusion: The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time. The improvement was greater with the LNG-IUS, compared with CMTs.

No MeSH data available.


Related in: MedlinePlus

Satisfaction with the LNG-IUS versus CMT at last visit or at end of therapy.Notes: Satisfaction was recorded by a four-point Likert-like scale (very satisfied to dissatisfied). The difference between the groups was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system.
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f1-ijwh-6-547: Satisfaction with the LNG-IUS versus CMT at last visit or at end of therapy.Notes: Satisfaction was recorded by a four-point Likert-like scale (very satisfied to dissatisfied). The difference between the groups was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system.

Mentions: In the LNG-IUS group, over 80% of patients were “very satisfied” or “satisfied” with their therapy for HMB, compared with 59.2% of the patients using CMTs (Figure 1). The difference between treatment groups was statistically significant (two-sided Fisher’s exact test for satisfaction at last visit documented: P<0.05; logrank test for time-to-event: P<0.0001). In the CMTs group, there were no marked differences in the satisfaction rates within individual treatments (hormonal versus antifibrinolytic versus combined).


Satisfaction and health-related quality of life in women with heavy menstrual bleeding; results from a non-interventional trial of the levonorgestrel-releasing intrauterine system or conventional medical therapy.

Xu L, Lee BS, Asif S, Kraemer P, Inki P - Int J Womens Health (2014)

Satisfaction with the LNG-IUS versus CMT at last visit or at end of therapy.Notes: Satisfaction was recorded by a four-point Likert-like scale (very satisfied to dissatisfied). The difference between the groups was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043813&req=5

f1-ijwh-6-547: Satisfaction with the LNG-IUS versus CMT at last visit or at end of therapy.Notes: Satisfaction was recorded by a four-point Likert-like scale (very satisfied to dissatisfied). The difference between the groups was statistically significant (P<0.05).Abbreviations: CMT, conventional medical treatment; LNG-IUS, levonorgestrel-releasing intrauterine system.
Mentions: In the LNG-IUS group, over 80% of patients were “very satisfied” or “satisfied” with their therapy for HMB, compared with 59.2% of the patients using CMTs (Figure 1). The difference between treatment groups was statistically significant (two-sided Fisher’s exact test for satisfaction at last visit documented: P<0.05; logrank test for time-to-event: P<0.0001). In the CMTs group, there were no marked differences in the satisfaction rates within individual treatments (hormonal versus antifibrinolytic versus combined).

Bottom Line: This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05).The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time.The improvement was greater with the LNG-IUS, compared with CMTs.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, People's Republic of China.

ABSTRACT

Purpose: To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB).

Patients and methods: A total of 647 patients diagnosed with HMB were recruited to this non-interventional study from the eight participating countries in Asia. Patient satisfaction was recorded at the last visit (at 12 months or premature discontinuation). At each visit (at 3, 6, and 12 months), patients completed the menorrhagia multi-attribute scale (MMAS) to assess HRQoL.

Results: A total of 83.5% of patients on the LNG-IUS were "very satisfied" or at least "satisfied" with the therapeutic effect of HMB treatment, compared with 59.2% of patients with CMTs (P<0.05). The mean (± standard deviation) MMAS score increased from 41.4±24.5 to 87.7±21.4 in the LNG-IUS arm, and from 44.1±24.9 to 73.1±25.3 in the CMTs arm. This increase was significantly higher in patients on the LNG-IUS, as compared with those on CMTs (P<0.05). The improvement in HRQoL in both treatment groups correlated with the body mass index of the patient, with larger improvement obtained in women with a higher body mass index.

Conclusion: The majority of women using the LNG-IUS or CMTs for HMB were satisfied with their treatment, and both treatment modalities were associated with significant improvements in HRQoL over time. The improvement was greater with the LNG-IUS, compared with CMTs.

No MeSH data available.


Related in: MedlinePlus