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Cardiovascular magnetic resonance-derived aortic compliance, distensibility and pulse wave velocity at rest and during a supine bicycle exercise in young adults: A pilot study

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The purpose of this study was to describe a technique to measure regional aortic compliance (AC), aortic distensibility (AD) and aortic stiffness with 1.5 T MRI in young individuals under resting conditions and during supine bicycle exercise... AC and AD were determined from cine-MRI at four locations, ascending aorta (AA), proximal descending aorta (PDA), distal descending aorta (DDA), and aorta above renal artery (RA)... Results All volunteer complete the whole protocol... Stress induced a significant decrease of AC and AD at all sites (p <10-3)... At rest and during stress, AC was statistically higher in AA compared to the whole descending aorta (p ≤0.0007)... We found a strong correlation between the rate pressure product and AC at all sites (Figure 1)... During exercise we measure a reduction of the aortic maximal diameter along the aortic arch (AA, p = 0.06 and PDA, p = 0.008) suggesting a contraction of the thoracic aorta during exercise... PWV measured at PDA and DDA increased significantly during stress (p = 0.02, p = 0.008, respectively)... Conclusion This study demonstrates the feasibility to analyze regional aortic function during an exercise-induced stress MRI... Further studies are required to evaluate its interest to detect AA's dysfunction among patients with thoracic aortic diseases.

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Mentions: Results All volunteer complete the whole protocol. Stress induced a significant decrease of AC and AD at all sites (p <10-3). At rest and during stress, AC was statistically higher in AA compared to the whole descending aorta (p ≤0.0007). We found a strong correlation between the rate pressure product and AC at all sites (Figure 1). During exercise we measure a reduction of the aortic maximal diameter along the aortic arch (AA, p = 0.06 and PDA, p = 0.008) suggesting a contraction of the thoracic aorta during exercise. PWV measured at PDA and DDA increased significantly during stress (p = 0.02, p = 0.008, respectively).


Cardiovascular magnetic resonance-derived aortic compliance, distensibility and pulse wave velocity at rest and during a supine bicycle exercise in young adults: A pilot study
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4043795&req=5

Mentions: Results All volunteer complete the whole protocol. Stress induced a significant decrease of AC and AD at all sites (p <10-3). At rest and during stress, AC was statistically higher in AA compared to the whole descending aorta (p ≤0.0007). We found a strong correlation between the rate pressure product and AC at all sites (Figure 1). During exercise we measure a reduction of the aortic maximal diameter along the aortic arch (AA, p = 0.06 and PDA, p = 0.008) suggesting a contraction of the thoracic aorta during exercise. PWV measured at PDA and DDA increased significantly during stress (p = 0.02, p = 0.008, respectively).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The purpose of this study was to describe a technique to measure regional aortic compliance (AC), aortic distensibility (AD) and aortic stiffness with 1.5 T MRI in young individuals under resting conditions and during supine bicycle exercise... AC and AD were determined from cine-MRI at four locations, ascending aorta (AA), proximal descending aorta (PDA), distal descending aorta (DDA), and aorta above renal artery (RA)... Results All volunteer complete the whole protocol... Stress induced a significant decrease of AC and AD at all sites (p <10-3)... At rest and during stress, AC was statistically higher in AA compared to the whole descending aorta (p ≤0.0007)... We found a strong correlation between the rate pressure product and AC at all sites (Figure 1)... During exercise we measure a reduction of the aortic maximal diameter along the aortic arch (AA, p = 0.06 and PDA, p = 0.008) suggesting a contraction of the thoracic aorta during exercise... PWV measured at PDA and DDA increased significantly during stress (p = 0.02, p = 0.008, respectively)... Conclusion This study demonstrates the feasibility to analyze regional aortic function during an exercise-induced stress MRI... Further studies are required to evaluate its interest to detect AA's dysfunction among patients with thoracic aortic diseases.

No MeSH data available.