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Breath-hold spiral tissue phase velocity mapping (TPVM) with non-Cartesian SENSE

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TPVM is the only MR technique capable of measuring regional myocardial mechanics over the entire cardiac cycle... Previous Cartesian breath-hold TPVM sequences have had low temporal resolution (eg ), limiting temporal detail, while navigator sequences are long and difficult to use clinically... This abstract presents a new spiral TPVM sequence which is capable of acquiring high temporal resolution TPVM data over the entire cardiac cycle within a clinically acceptable breath-hold duration... Basal, mid and apical short-axis slices were acquired in 10 volunteers and from the mid-slice of 1 early stage DCM patient (LVEF 49%, EDV 188 mL, ESV 96 mL) and one late stage DCM patient (LVEF 21%, EDV 326 mL, ESV 258 mL) on a Siemens Skyra 3T scanner... Figure 1b shows mid-slice healthy mean (+/- SD) peak and time to peak velocities as well as the individual patient values... Longitudinal peaks in the early DCM patient are normal but radial values are clearly reduced... For the late stage patient, velocities in all directions are reduced... Figure 2 shows regional velocity variation (y-axis) over time (x-axis) in the mid slice of one volunteer and both patients... Regional abnormalities can be seen in the radial direction of the early DCM example, although longitudinal velocities are normal... The late DCM patient has clearly abnormal regional variation in all directions, particularly in early diastole... Spiral trajectories and non-Cartesian SENSE has allowed acquisition of high temporal resolution TPVM images within a clinically achievable breath-hold and allows acquisition and reconstruction of a full short axis stack within 30 minutes... Initial clinical examples indicate that this technique is capable of detecting reduced radial velocities in early DCM when global parameters of motion are still within the normal range.

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a) Global velocities from 9 short axis slices in one volunteer (each curve represents velocity averaged over a slice). In longitudinal and radial directions one systolic (SL/SR), one early diastolic (DL/DR) and one atrial systolic (ASL/ASR) peak is seen. Longitudinal peaks reduce from base to apex, while radial peaks do not. Two systolic circumferential peaks (C1 and C2) are seen, as well as a diastolic peak (C3) which is negative at base but positive at apex. b) Peak and TTP global velocity values in the mid slice for the healthy volunteers (mean ± SD values shown by red bars), early DCM patient (green crosses) and late DCM patient (blue crosses). Healthy values show small standard deviations (although circumferential peaks are more variable). C3 is not shown as it is very slice-position dependent not always seen in the mid slice. The early stage patient shows normal longitudinal values but reduced radial values, whereas the late stage patient shows reduced peak values in all directions.
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Figure 1: a) Global velocities from 9 short axis slices in one volunteer (each curve represents velocity averaged over a slice). In longitudinal and radial directions one systolic (SL/SR), one early diastolic (DL/DR) and one atrial systolic (ASL/ASR) peak is seen. Longitudinal peaks reduce from base to apex, while radial peaks do not. Two systolic circumferential peaks (C1 and C2) are seen, as well as a diastolic peak (C3) which is negative at base but positive at apex. b) Peak and TTP global velocity values in the mid slice for the healthy volunteers (mean ± SD values shown by red bars), early DCM patient (green crosses) and late DCM patient (blue crosses). Healthy values show small standard deviations (although circumferential peaks are more variable). C3 is not shown as it is very slice-position dependent not always seen in the mid slice. The early stage patient shows normal longitudinal values but reduced radial values, whereas the late stage patient shows reduced peak values in all directions.

Mentions: Figure 1a shows global velocities measured from the 9 short axis slices in one volunteer with velocity peaks labelled. This shows smooth changes from base to apex that have only previously been seen in lengthy 3D acquisitions [5]. Figure 1b shows mid-slice healthy mean (+/- SD) peak and time to peak velocities as well as the individual patient values. Longitudinal peaks in the early DCM patient are normal but radial values are clearly reduced. For the late stage patient, velocities in all directions are reduced. Figure 2 shows regional velocity variation (y-axis) over time (x-axis) in the mid slice of one volunteer and both patients. Regional abnormalities can be seen in the radial direction of the early DCM example, although longitudinal velocities are normal. The late DCM patient has clearly abnormal regional variation in all directions, particularly in early diastole.


Breath-hold spiral tissue phase velocity mapping (TPVM) with non-Cartesian SENSE
a) Global velocities from 9 short axis slices in one volunteer (each curve represents velocity averaged over a slice). In longitudinal and radial directions one systolic (SL/SR), one early diastolic (DL/DR) and one atrial systolic (ASL/ASR) peak is seen. Longitudinal peaks reduce from base to apex, while radial peaks do not. Two systolic circumferential peaks (C1 and C2) are seen, as well as a diastolic peak (C3) which is negative at base but positive at apex. b) Peak and TTP global velocity values in the mid slice for the healthy volunteers (mean ± SD values shown by red bars), early DCM patient (green crosses) and late DCM patient (blue crosses). Healthy values show small standard deviations (although circumferential peaks are more variable). C3 is not shown as it is very slice-position dependent not always seen in the mid slice. The early stage patient shows normal longitudinal values but reduced radial values, whereas the late stage patient shows reduced peak values in all directions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
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getmorefigures.php?uid=PMC4043792&req=5

Figure 1: a) Global velocities from 9 short axis slices in one volunteer (each curve represents velocity averaged over a slice). In longitudinal and radial directions one systolic (SL/SR), one early diastolic (DL/DR) and one atrial systolic (ASL/ASR) peak is seen. Longitudinal peaks reduce from base to apex, while radial peaks do not. Two systolic circumferential peaks (C1 and C2) are seen, as well as a diastolic peak (C3) which is negative at base but positive at apex. b) Peak and TTP global velocity values in the mid slice for the healthy volunteers (mean ± SD values shown by red bars), early DCM patient (green crosses) and late DCM patient (blue crosses). Healthy values show small standard deviations (although circumferential peaks are more variable). C3 is not shown as it is very slice-position dependent not always seen in the mid slice. The early stage patient shows normal longitudinal values but reduced radial values, whereas the late stage patient shows reduced peak values in all directions.
Mentions: Figure 1a shows global velocities measured from the 9 short axis slices in one volunteer with velocity peaks labelled. This shows smooth changes from base to apex that have only previously been seen in lengthy 3D acquisitions [5]. Figure 1b shows mid-slice healthy mean (+/- SD) peak and time to peak velocities as well as the individual patient values. Longitudinal peaks in the early DCM patient are normal but radial values are clearly reduced. For the late stage patient, velocities in all directions are reduced. Figure 2 shows regional velocity variation (y-axis) over time (x-axis) in the mid slice of one volunteer and both patients. Regional abnormalities can be seen in the radial direction of the early DCM example, although longitudinal velocities are normal. The late DCM patient has clearly abnormal regional variation in all directions, particularly in early diastole.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

TPVM is the only MR technique capable of measuring regional myocardial mechanics over the entire cardiac cycle... Previous Cartesian breath-hold TPVM sequences have had low temporal resolution (eg ), limiting temporal detail, while navigator sequences are long and difficult to use clinically... This abstract presents a new spiral TPVM sequence which is capable of acquiring high temporal resolution TPVM data over the entire cardiac cycle within a clinically acceptable breath-hold duration... Basal, mid and apical short-axis slices were acquired in 10 volunteers and from the mid-slice of 1 early stage DCM patient (LVEF 49%, EDV 188 mL, ESV 96 mL) and one late stage DCM patient (LVEF 21%, EDV 326 mL, ESV 258 mL) on a Siemens Skyra 3T scanner... Figure 1b shows mid-slice healthy mean (+/- SD) peak and time to peak velocities as well as the individual patient values... Longitudinal peaks in the early DCM patient are normal but radial values are clearly reduced... For the late stage patient, velocities in all directions are reduced... Figure 2 shows regional velocity variation (y-axis) over time (x-axis) in the mid slice of one volunteer and both patients... Regional abnormalities can be seen in the radial direction of the early DCM example, although longitudinal velocities are normal... The late DCM patient has clearly abnormal regional variation in all directions, particularly in early diastole... Spiral trajectories and non-Cartesian SENSE has allowed acquisition of high temporal resolution TPVM images within a clinically achievable breath-hold and allows acquisition and reconstruction of a full short axis stack within 30 minutes... Initial clinical examples indicate that this technique is capable of detecting reduced radial velocities in early DCM when global parameters of motion are still within the normal range.

No MeSH data available.


Related in: MedlinePlus