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Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles.

Mas N, Galiana I, Hurtado S, Mondragón L, Bernardos A, Sancenón F, Marcos MD, Amorós P, Abril-Utrillas N, Martínez-Máñez R, Murguía JR - Int J Nanomedicine (2014)

Bottom Line: pH-sensitive gated mesoporous silica nanoparticles have been synthesized.Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole.Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity.

View Article: PubMed Central - PubMed

Affiliation: Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain ; Departamento de Química, Universidad Politécnica de Valencia, Valencia, Spain ; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain.

ABSTRACT
pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity. As alterations of acidic external pH are a key parameter in the onset of fungal vaginitis, this nanodevice could improve the treatment for vaginal mycoses.

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S1-Teb characterization results. (A) Powder X-ray pattern of MCM-41 as made, MCM-41 calcined, and S1-Teb. (B) Transmission electron microscopy image of MCM-41 calcined and S1-Teb.Abbreviations: MCM-41, mobil composition of matter-41; S1-Teb, MCM-41 loaded with tebuconazole.
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f2-ijn-9-2597: S1-Teb characterization results. (A) Powder X-ray pattern of MCM-41 as made, MCM-41 calcined, and S1-Teb. (B) Transmission electron microscopy image of MCM-41 calcined and S1-Teb.Abbreviations: MCM-41, mobil composition of matter-41; S1-Teb, MCM-41 loaded with tebuconazole.

Mentions: The MCM-41 structure was confirmed by PXRD and TEM techniques (see Figure 2A and B), which presented the expected features of this type of mesoporous material.


Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles.

Mas N, Galiana I, Hurtado S, Mondragón L, Bernardos A, Sancenón F, Marcos MD, Amorós P, Abril-Utrillas N, Martínez-Máñez R, Murguía JR - Int J Nanomedicine (2014)

S1-Teb characterization results. (A) Powder X-ray pattern of MCM-41 as made, MCM-41 calcined, and S1-Teb. (B) Transmission electron microscopy image of MCM-41 calcined and S1-Teb.Abbreviations: MCM-41, mobil composition of matter-41; S1-Teb, MCM-41 loaded with tebuconazole.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043724&req=5

f2-ijn-9-2597: S1-Teb characterization results. (A) Powder X-ray pattern of MCM-41 as made, MCM-41 calcined, and S1-Teb. (B) Transmission electron microscopy image of MCM-41 calcined and S1-Teb.Abbreviations: MCM-41, mobil composition of matter-41; S1-Teb, MCM-41 loaded with tebuconazole.
Mentions: The MCM-41 structure was confirmed by PXRD and TEM techniques (see Figure 2A and B), which presented the expected features of this type of mesoporous material.

Bottom Line: pH-sensitive gated mesoporous silica nanoparticles have been synthesized.Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole.Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity.

View Article: PubMed Central - PubMed

Affiliation: Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain ; Departamento de Química, Universidad Politécnica de Valencia, Valencia, Spain ; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain.

ABSTRACT
pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity. As alterations of acidic external pH are a key parameter in the onset of fungal vaginitis, this nanodevice could improve the treatment for vaginal mycoses.

Show MeSH
Related in: MedlinePlus