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Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles.

Mas N, Galiana I, Hurtado S, Mondragón L, Bernardos A, Sancenón F, Marcos MD, Amorós P, Abril-Utrillas N, Martínez-Máñez R, Murguía JR - Int J Nanomedicine (2014)

Bottom Line: pH-sensitive gated mesoporous silica nanoparticles have been synthesized.Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole.Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity.

View Article: PubMed Central - PubMed

Affiliation: Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain ; Departamento de Química, Universidad Politécnica de Valencia, Valencia, Spain ; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain.

ABSTRACT
pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity. As alterations of acidic external pH are a key parameter in the onset of fungal vaginitis, this nanodevice could improve the treatment for vaginal mycoses.

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Schematic representation of the design and action mechanism of S1-Teb under usual vaginal conditions (A) and in the presence of Candida albicans (B) (Saccharomyces cerevisiae has been used in experimental assays as a model organism).Abbreviation: MCM-41, mobil composition of matter-41; S1-Teb, MCM-41 loaded with tebuconazole.
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f1-ijn-9-2597: Schematic representation of the design and action mechanism of S1-Teb under usual vaginal conditions (A) and in the presence of Candida albicans (B) (Saccharomyces cerevisiae has been used in experimental assays as a model organism).Abbreviation: MCM-41, mobil composition of matter-41; S1-Teb, MCM-41 loaded with tebuconazole.

Mentions: After these satisfactory results with S1-FL nanoparticles, we next designed, prepared, characterized, and tested a new material, S1-Teb, as a possible therapeutic antifungal carrier. This nanoparticle design and action mechanism is shown in Figure 1.


Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles.

Mas N, Galiana I, Hurtado S, Mondragón L, Bernardos A, Sancenón F, Marcos MD, Amorós P, Abril-Utrillas N, Martínez-Máñez R, Murguía JR - Int J Nanomedicine (2014)

Schematic representation of the design and action mechanism of S1-Teb under usual vaginal conditions (A) and in the presence of Candida albicans (B) (Saccharomyces cerevisiae has been used in experimental assays as a model organism).Abbreviation: MCM-41, mobil composition of matter-41; S1-Teb, MCM-41 loaded with tebuconazole.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4043724&req=5

f1-ijn-9-2597: Schematic representation of the design and action mechanism of S1-Teb under usual vaginal conditions (A) and in the presence of Candida albicans (B) (Saccharomyces cerevisiae has been used in experimental assays as a model organism).Abbreviation: MCM-41, mobil composition of matter-41; S1-Teb, MCM-41 loaded with tebuconazole.
Mentions: After these satisfactory results with S1-FL nanoparticles, we next designed, prepared, characterized, and tested a new material, S1-Teb, as a possible therapeutic antifungal carrier. This nanoparticle design and action mechanism is shown in Figure 1.

Bottom Line: pH-sensitive gated mesoporous silica nanoparticles have been synthesized.Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole.Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity.

View Article: PubMed Central - PubMed

Affiliation: Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain ; Departamento de Química, Universidad Politécnica de Valencia, Valencia, Spain ; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain.

ABSTRACT
pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly enhanced tebuconazole cytotoxicity. As alterations of acidic external pH are a key parameter in the onset of fungal vaginitis, this nanodevice could improve the treatment for vaginal mycoses.

Show MeSH
Related in: MedlinePlus