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The association between microvascular obstruction by CMR and the index of microcirculatory resistance assessed invasively

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Microvascular obstruction (MVO) by CMR is a predictor of poor prognosis following acute myocardial infarction... The index of microcirculatory resistance (IMR) is an invasive measurement of the microcirculation that has recently been shown to predict poor long-term outcomes... The aim of the study was to determine the association between MVO by CMR and the IMR measured at the time of primary percutaneous intervention (PPCI) in patients with ST-elevation myocardial infarction (STEMI). 48 patients were prospectively recruited to the study... We used an IMR cut off of 40 that has been shown to predict prognosis(1), and IMR quartiles to investigate an association between MVO and IMR... All patients provided informed written consent and the study was approved by the regional ethics committee... The median MVO was 1.9% LV (range 0 to 21.0% LV)... There was a significant increase in MVO as IMR increased (p = 0.007) (Figure 1a)... This is more pronounced when MVO was indexed to infarct size (MVO/Infarct size, MVOI) (p = 0.003) (Figure 1b)... The IMR cut-off of 40 significantly predicted the presence of MVO on CMR (p = 0.0003) (Figure 2)... IMR is significantly associated with MVO on CMR day 2 following STEMI... This study provides an invasive functional insight into MVO measured non-invasively by CMR.

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a) MVO vs. IMR (p = 0.007) Figure 1b) MVOI vs. IMR (p = 0.003).
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Figure 1: a) MVO vs. IMR (p = 0.007) Figure 1b) MVOI vs. IMR (p = 0.003).

Mentions: The median IMR was 38.5 (range 9 to 202). The median MVO was 1.9% LV (range 0 to 21.0% LV). There was a significant increase in MVO as IMR increased (p = 0.007) (Figure 1a). This is more pronounced when MVO was indexed to infarct size (MVO/Infarct size, MVOI) (p = 0.003) (Figure 1b). The IMR cut-off of 40 significantly predicted the presence of MVO on CMR (p = 0.0003) (Figure 2).


The association between microvascular obstruction by CMR and the index of microcirculatory resistance assessed invasively
a) MVO vs. IMR (p = 0.007) Figure 1b) MVOI vs. IMR (p = 0.003).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
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getmorefigures.php?uid=PMC4043231&req=5

Figure 1: a) MVO vs. IMR (p = 0.007) Figure 1b) MVOI vs. IMR (p = 0.003).
Mentions: The median IMR was 38.5 (range 9 to 202). The median MVO was 1.9% LV (range 0 to 21.0% LV). There was a significant increase in MVO as IMR increased (p = 0.007) (Figure 1a). This is more pronounced when MVO was indexed to infarct size (MVO/Infarct size, MVOI) (p = 0.003) (Figure 1b). The IMR cut-off of 40 significantly predicted the presence of MVO on CMR (p = 0.0003) (Figure 2).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Microvascular obstruction (MVO) by CMR is a predictor of poor prognosis following acute myocardial infarction... The index of microcirculatory resistance (IMR) is an invasive measurement of the microcirculation that has recently been shown to predict poor long-term outcomes... The aim of the study was to determine the association between MVO by CMR and the IMR measured at the time of primary percutaneous intervention (PPCI) in patients with ST-elevation myocardial infarction (STEMI). 48 patients were prospectively recruited to the study... We used an IMR cut off of 40 that has been shown to predict prognosis(1), and IMR quartiles to investigate an association between MVO and IMR... All patients provided informed written consent and the study was approved by the regional ethics committee... The median MVO was 1.9% LV (range 0 to 21.0% LV)... There was a significant increase in MVO as IMR increased (p = 0.007) (Figure 1a)... This is more pronounced when MVO was indexed to infarct size (MVO/Infarct size, MVOI) (p = 0.003) (Figure 1b)... The IMR cut-off of 40 significantly predicted the presence of MVO on CMR (p = 0.0003) (Figure 2)... IMR is significantly associated with MVO on CMR day 2 following STEMI... This study provides an invasive functional insight into MVO measured non-invasively by CMR.

No MeSH data available.