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Validation of Siemens T2* inline WIP package for quantification of cardiac and hepatic iron loading at 1.5T and 3T

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The ability of T2* cardiovascular magnetic resonance (CMR) to identify cardiac iron loading has facilitated a dramatic reduction in mortality in patients with iron overload... There remains a worldwide need for improved access to iron evaluation... We compared our validated T2* methods which use Royal Brompton Hospital (RBH) T2* sequences with analysis by CMRtools against a novel work-in-progress (WIP) sequence and inline T2* analysis. 22 healthy volunteers and 78 patients were recruited (thalassaemia major 39, sickle cell disease 15, hereditary hemochromatosis 10, other iron overload conditions 14) who were referred for routine iron assessment (53 male, aged 13 to 81 years)... A 1.5T study (MAGNETOM Avanto, Siemens AG Healthcare Sector, Erlangen, Germany) was performed on all subjects, from whom a subset of 50 underwent an additional 3T study (MAGNETOM Skyra)... At 1.5T, liver T2* values ranged from 0.8-33 ms (median 5.1 ms) and cardiac T2* values from 6.6-49 ms (median 31 ms)... There was good agreement between RBH-CMRtools T2* and Siemens T2* WIP maps with results close to the line of identity and linear regression close to 1 (Figure 1); Rvalues for WB, BB and liver T2* were 0.969, 0.945 and 0.995 respectively at 1.5T and 0.963, 0.982 and 0.993 respectively at 3T... Accurate delineation of the septum was difficult on some T2* WIP maps due to artefacts... The inability to manually correct for noise by truncation of erroneous later echo times lead to some overestimation of T2* using the WIP technique compared to RBH-CMRtools... The Siemens WIP T2* mapping sequence and analysis performed well against the standard RBH-CMRtools T2* package at both 1.5T and 3T... Inline T2* mapping in combination with a simple ROI analysis has the potential to improve global access to iron assessment.

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Plots showing correlation of RBH T2* with Siemens WIP T2* for white blood (WB), black blood (BB) and liver at 1.5T and 3T respectively.
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Figure 1: Plots showing correlation of RBH T2* with Siemens WIP T2* for white blood (WB), black blood (BB) and liver at 1.5T and 3T respectively.

Mentions: At 1.5T, liver T2* values ranged from 0.8-33 ms (median 5.1 ms) and cardiac T2* values from 6.6-49 ms (median 31 ms). There was good agreement between RBH-CMRtools T2* and Siemens T2* WIP maps with results close to the line of identity and linear regression close to 1 (Figure 1); R2 values for WB, BB and liver T2* were 0.969, 0.945 and 0.995 respectively at 1.5T and 0.963, 0.982 and 0.993 respectively at 3T. The coefficient of variation was 5.5-7.6% across techniques at 1.5 T and 5.5-7.9% at 3T. Accurate delineation of the septum was difficult on some T2* WIP maps due to artefacts. The inability to manually correct for noise by truncation of erroneous later echo times lead to some overestimation of T2* using the WIP technique compared to RBH-CMRtools.


Validation of Siemens T2* inline WIP package for quantification of cardiac and hepatic iron loading at 1.5T and 3T
Plots showing correlation of RBH T2* with Siemens WIP T2* for white blood (WB), black blood (BB) and liver at 1.5T and 3T respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4043195&req=5

Figure 1: Plots showing correlation of RBH T2* with Siemens WIP T2* for white blood (WB), black blood (BB) and liver at 1.5T and 3T respectively.
Mentions: At 1.5T, liver T2* values ranged from 0.8-33 ms (median 5.1 ms) and cardiac T2* values from 6.6-49 ms (median 31 ms). There was good agreement between RBH-CMRtools T2* and Siemens T2* WIP maps with results close to the line of identity and linear regression close to 1 (Figure 1); R2 values for WB, BB and liver T2* were 0.969, 0.945 and 0.995 respectively at 1.5T and 0.963, 0.982 and 0.993 respectively at 3T. The coefficient of variation was 5.5-7.6% across techniques at 1.5 T and 5.5-7.9% at 3T. Accurate delineation of the septum was difficult on some T2* WIP maps due to artefacts. The inability to manually correct for noise by truncation of erroneous later echo times lead to some overestimation of T2* using the WIP technique compared to RBH-CMRtools.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The ability of T2* cardiovascular magnetic resonance (CMR) to identify cardiac iron loading has facilitated a dramatic reduction in mortality in patients with iron overload... There remains a worldwide need for improved access to iron evaluation... We compared our validated T2* methods which use Royal Brompton Hospital (RBH) T2* sequences with analysis by CMRtools against a novel work-in-progress (WIP) sequence and inline T2* analysis. 22 healthy volunteers and 78 patients were recruited (thalassaemia major 39, sickle cell disease 15, hereditary hemochromatosis 10, other iron overload conditions 14) who were referred for routine iron assessment (53 male, aged 13 to 81 years)... A 1.5T study (MAGNETOM Avanto, Siemens AG Healthcare Sector, Erlangen, Germany) was performed on all subjects, from whom a subset of 50 underwent an additional 3T study (MAGNETOM Skyra)... At 1.5T, liver T2* values ranged from 0.8-33 ms (median 5.1 ms) and cardiac T2* values from 6.6-49 ms (median 31 ms)... There was good agreement between RBH-CMRtools T2* and Siemens T2* WIP maps with results close to the line of identity and linear regression close to 1 (Figure 1); Rvalues for WB, BB and liver T2* were 0.969, 0.945 and 0.995 respectively at 1.5T and 0.963, 0.982 and 0.993 respectively at 3T... Accurate delineation of the septum was difficult on some T2* WIP maps due to artefacts... The inability to manually correct for noise by truncation of erroneous later echo times lead to some overestimation of T2* using the WIP technique compared to RBH-CMRtools... The Siemens WIP T2* mapping sequence and analysis performed well against the standard RBH-CMRtools T2* package at both 1.5T and 3T... Inline T2* mapping in combination with a simple ROI analysis has the potential to improve global access to iron assessment.

No MeSH data available.