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Evolution of cardiorespiratory interactions with age.

Iatsenko D, Bernjak A, Stankovski T, Shiogai Y, Owen-Lynch PJ, Clarkson PB, McClintock PV, Stefanovska A - Philos Trans A Math Phys Eng Sci (2013)

Bottom Line: We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90.By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure.We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Lancaster University, Lancaster LA1 4YB, UK.

ABSTRACT
We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

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(a–f) Dependence on age of the different contributions to coupling directionality (see text).
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RSTA20110622F7: (a–f) Dependence on age of the different contributions to coupling directionality (see text).

Mentions: Figure 7 shows time-averages of the different contributions to the cardiorespiratory interaction, as well as their mutual relationships. It is evident that both the direct and indirect influences of respiration on the heart are negatively correlated with age (figure 7a,b), with the direct contribution decreasing faster than the indirect one (figure 7c). At the same time, contributions to the influence of the heart on respiration and the corresponding indirect/direct ratio exhibit no significant age dependence (figure 7d–f). Thus, the decreases with age of and coupling directionality are completely attributable to the combined effects of a decrease in RSA and the indirect effect of respiration on the heart.Figure 7.


Evolution of cardiorespiratory interactions with age.

Iatsenko D, Bernjak A, Stankovski T, Shiogai Y, Owen-Lynch PJ, Clarkson PB, McClintock PV, Stefanovska A - Philos Trans A Math Phys Eng Sci (2013)

(a–f) Dependence on age of the different contributions to coupling directionality (see text).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042892&req=5

RSTA20110622F7: (a–f) Dependence on age of the different contributions to coupling directionality (see text).
Mentions: Figure 7 shows time-averages of the different contributions to the cardiorespiratory interaction, as well as their mutual relationships. It is evident that both the direct and indirect influences of respiration on the heart are negatively correlated with age (figure 7a,b), with the direct contribution decreasing faster than the indirect one (figure 7c). At the same time, contributions to the influence of the heart on respiration and the corresponding indirect/direct ratio exhibit no significant age dependence (figure 7d–f). Thus, the decreases with age of and coupling directionality are completely attributable to the combined effects of a decrease in RSA and the indirect effect of respiration on the heart.Figure 7.

Bottom Line: We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90.By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure.We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Lancaster University, Lancaster LA1 4YB, UK.

ABSTRACT
We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

Show MeSH
Related in: MedlinePlus