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Evolution of cardiorespiratory interactions with age.

Iatsenko D, Bernjak A, Stankovski T, Shiogai Y, Owen-Lynch PJ, Clarkson PB, McClintock PV, Stefanovska A - Philos Trans A Math Phys Eng Sci (2013)

Bottom Line: We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90.By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure.We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Lancaster University, Lancaster LA1 4YB, UK.

ABSTRACT
We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

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Evolution with age in the strength and direction of cardiorespiratory influence. (a) Influence of respiration on the heart, . (b) Influence of the heart on respiration, . (c) The net directionality of coupling, D, from respiration to heart. (d) Standard deviation of the directionality of coupling. In (a–c), the time-averages are shown.
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RSTA20110622F6: Evolution with age in the strength and direction of cardiorespiratory influence. (a) Influence of respiration on the heart, . (b) Influence of the heart on respiration, . (c) The net directionality of coupling, D, from respiration to heart. (d) Standard deviation of the directionality of coupling. In (a–c), the time-averages are shown.

Mentions: Figure 6 shows the dependence on age of the time-averaged , and the resultant coupling directionality D together with its standard deviation. It is clear from figure 6a that the influence of respiration on the heart has significant negative correlation with age, whereas the influence of the heart on respiration is not age-dependent as shown in figure 6b. As a result, the time-average of coupling directionality significantly decreases with age (figure 6c). At the same time, its standard deviation increases with age (figure 6d), implying that the cardiorespiratory interaction also becomes less stable.Figure 6.


Evolution of cardiorespiratory interactions with age.

Iatsenko D, Bernjak A, Stankovski T, Shiogai Y, Owen-Lynch PJ, Clarkson PB, McClintock PV, Stefanovska A - Philos Trans A Math Phys Eng Sci (2013)

Evolution with age in the strength and direction of cardiorespiratory influence. (a) Influence of respiration on the heart, . (b) Influence of the heart on respiration, . (c) The net directionality of coupling, D, from respiration to heart. (d) Standard deviation of the directionality of coupling. In (a–c), the time-averages are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042892&req=5

RSTA20110622F6: Evolution with age in the strength and direction of cardiorespiratory influence. (a) Influence of respiration on the heart, . (b) Influence of the heart on respiration, . (c) The net directionality of coupling, D, from respiration to heart. (d) Standard deviation of the directionality of coupling. In (a–c), the time-averages are shown.
Mentions: Figure 6 shows the dependence on age of the time-averaged , and the resultant coupling directionality D together with its standard deviation. It is clear from figure 6a that the influence of respiration on the heart has significant negative correlation with age, whereas the influence of the heart on respiration is not age-dependent as shown in figure 6b. As a result, the time-average of coupling directionality significantly decreases with age (figure 6c). At the same time, its standard deviation increases with age (figure 6d), implying that the cardiorespiratory interaction also becomes less stable.Figure 6.

Bottom Line: We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90.By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure.We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Lancaster University, Lancaster LA1 4YB, UK.

ABSTRACT
We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time resolution than is possible with the marked events procedure. By treating the heart and respiration as coupled oscillators, we then apply a method based on Bayesian inference to find the underlying coupling parameters and their time dependence, deriving from them measures such as synchronization, coupling directionality and the relative contributions of different mechanisms. We report a detailed analysis of the reconstructed cardiorespiratory coupling function, its time evolution and age dependence. We show that the direct and indirect respiratory modulations of the heart rate both decrease with age, and that the cardiorespiratory coupling becomes less stable and more time-variable.

Show MeSH
Related in: MedlinePlus