Limits...
Induction of plasticity in the human motor cortex by pairing an auditory stimulus with TMS.

Sowman PF, Dueholm SS, Rasmussen JH, Mrachacz-Kersting N - Front Hum Neurosci (2014)

Bottom Line: Acoustic stimuli can cause a transient increase in the excitability of the motor cortex.We demonstrate that appropriately timed transcranial magnetic stimulation (TMS) of the hand area, paired with auditorily mediated excitation of the motor cortex, induces an enhancement of motor cortex excitability that lasts beyond the time of stimulation.This result demonstrates for the first time that paired associative stimulation (PAS)-induced plasticity within the motor cortex is applicable with auditory stimuli.

View Article: PubMed Central - PubMed

Affiliation: Department of Cognitive Science, Macquarie University Sydney, NSW, Australia ; Perception and Action Research Centre (PARC), Faculty of Human Sciences, Macquarie University Sydney, NSW, Australia ; Australian Research Council Centre of Excellence in Cognition and its Disorders (CCD), Macquarie University Sydney, NSW, Australia.

ABSTRACT
Acoustic stimuli can cause a transient increase in the excitability of the motor cortex. The current study leverages this phenomenon to develop a method for testing the integrity of auditorimotor integration and the capacity for auditorimotor plasticity. We demonstrate that appropriately timed transcranial magnetic stimulation (TMS) of the hand area, paired with auditorily mediated excitation of the motor cortex, induces an enhancement of motor cortex excitability that lasts beyond the time of stimulation. This result demonstrates for the first time that paired associative stimulation (PAS)-induced plasticity within the motor cortex is applicable with auditory stimuli. We propose that the method developed here might provide a useful tool for future studies that measure auditory-motor connectivity in communication disorders.

No MeSH data available.


Related in: MedlinePlus

Averaged post- and post15-MEP-amplitudes (+SEM) as percentage of baseline (n= 10). Baseline is represented by the red horizontal line. * denotes average amplitude significantly different from baseline (* < 0.05, ** < 0.01).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4042887&req=5

Figure 3: Averaged post- and post15-MEP-amplitudes (+SEM) as percentage of baseline (n= 10). Baseline is represented by the red horizontal line. * denotes average amplitude significantly different from baseline (* < 0.05, ** < 0.01).

Mentions: Results from Experiment B show that across all subjects the averaged MEP peak-to-peak amplitude increased to 148% (post) and 165% (post15) of baseline as shown in Figure 3. Two-tailed one-sample t-tests showed a significant increase in normalized MEP peak-to-peak amplitude for post (t(9) = 3.8, p = 0.004) and post15 (t(9) = 2.9, p = 0.018). Comparison between post and post15 by means of a paired t-test revealed no significant difference (t(9) = 1.06, p = 0.32).


Induction of plasticity in the human motor cortex by pairing an auditory stimulus with TMS.

Sowman PF, Dueholm SS, Rasmussen JH, Mrachacz-Kersting N - Front Hum Neurosci (2014)

Averaged post- and post15-MEP-amplitudes (+SEM) as percentage of baseline (n= 10). Baseline is represented by the red horizontal line. * denotes average amplitude significantly different from baseline (* < 0.05, ** < 0.01).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042887&req=5

Figure 3: Averaged post- and post15-MEP-amplitudes (+SEM) as percentage of baseline (n= 10). Baseline is represented by the red horizontal line. * denotes average amplitude significantly different from baseline (* < 0.05, ** < 0.01).
Mentions: Results from Experiment B show that across all subjects the averaged MEP peak-to-peak amplitude increased to 148% (post) and 165% (post15) of baseline as shown in Figure 3. Two-tailed one-sample t-tests showed a significant increase in normalized MEP peak-to-peak amplitude for post (t(9) = 3.8, p = 0.004) and post15 (t(9) = 2.9, p = 0.018). Comparison between post and post15 by means of a paired t-test revealed no significant difference (t(9) = 1.06, p = 0.32).

Bottom Line: Acoustic stimuli can cause a transient increase in the excitability of the motor cortex.We demonstrate that appropriately timed transcranial magnetic stimulation (TMS) of the hand area, paired with auditorily mediated excitation of the motor cortex, induces an enhancement of motor cortex excitability that lasts beyond the time of stimulation.This result demonstrates for the first time that paired associative stimulation (PAS)-induced plasticity within the motor cortex is applicable with auditory stimuli.

View Article: PubMed Central - PubMed

Affiliation: Department of Cognitive Science, Macquarie University Sydney, NSW, Australia ; Perception and Action Research Centre (PARC), Faculty of Human Sciences, Macquarie University Sydney, NSW, Australia ; Australian Research Council Centre of Excellence in Cognition and its Disorders (CCD), Macquarie University Sydney, NSW, Australia.

ABSTRACT
Acoustic stimuli can cause a transient increase in the excitability of the motor cortex. The current study leverages this phenomenon to develop a method for testing the integrity of auditorimotor integration and the capacity for auditorimotor plasticity. We demonstrate that appropriately timed transcranial magnetic stimulation (TMS) of the hand area, paired with auditorily mediated excitation of the motor cortex, induces an enhancement of motor cortex excitability that lasts beyond the time of stimulation. This result demonstrates for the first time that paired associative stimulation (PAS)-induced plasticity within the motor cortex is applicable with auditory stimuli. We propose that the method developed here might provide a useful tool for future studies that measure auditory-motor connectivity in communication disorders.

No MeSH data available.


Related in: MedlinePlus